A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation

The coronavirus disease 2019 (COVID-19) pandemic underscores the need to better understand animal-to-human transmission of coronaviruses and adaptive evolution within new hosts. We scanned more than 182,000 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes for selective sweep sign...

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Veröffentlicht in:	Cell 2021-08, Vol.184 (17), p.4392-4400.e4
Hauptverfasser:	Kang, Lin, He, Guijuan, Sharp, Amanda K., Wang, Xiaofeng, Brown, Anne M., Michalak, Pawel, Weger-Lucarelli, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Angiotensin-Converting Enzyme 2 Animals Cell Line Chiroptera - virology Chlorocebus aethiops COVID-19 COVID-19 - virology Disease Reservoirs emergence Evolution, Molecular Genome, Viral Humans Models, Molecular molecular virology Mutation Phylogeny SARS-CoV-2 SARS-CoV-2 - genetics selective sweep Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism spillover Vero Cells viral adaptation
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