Increased vascular permeability and severe renal tubular damage after ischemia-reperfusion injury in mice lacking adiponectin or T-cadherin

Adiponectin (APN) is a circulating protein specifically produced by adipocytes. Native APN specifically binds to T-cadherin, a glycosylphosphatidylinositol-anchored protein, mediating the exosome-stimulating effects of APN in endothelial, muscle, and mesenchymal stem cells. It was previously reporte...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2021-02, Vol.320 (2), p.E179-E190
Hauptverfasser:	Tsugawa-Shimizu, Yuri, Fujishima, Yuya, Kita, Shunbun, Minami, Satoshi, Sakaue, Taka-Aki, Nakamura, Yuto, Okita, Tomonori, Kawachi, Yusuke, Fukada, Shiro, Namba-Hamano, Tomoko, Takabatake, Yoshitsugu, Isaka, Yoshitaka, Nishizawa, Hitoshi, Ranscht, Barbara, Maeda, Norikazu, Shimomura, Iichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adiponectin Adiponectin - genetics Animals Cadherins Cadherins - genetics Capillaries Capillary Permeability - genetics Cells, Cultured Damage Glycosylphosphatidylinositol Growth factors Immunofluorescence Injuries Ischemia Kidney diseases Kidney Diseases - etiology Kidney Diseases - genetics Kidney Diseases - pathology Kidney Tubules - pathology Kidneys Male Mesenchyme Mice Mice, Inbred C57BL Mice, Knockout Muscles Pericytes Permeability Phenotypes Platelet-derived growth factor Progenitor cells Proteins Reperfusion Reperfusion Injury - complications Reperfusion Injury - genetics Reperfusion Injury - pathology Rodents Severity of Illness Index Stem cell transplantation Stem cells T-cadherin
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