Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants

Since the start of the COVID-19 pandemic, SARS-CoV-2 has caused millions of deaths worldwide. Although a number of vaccines have been deployed, the continual evolution of the receptor-binding domain (RBD) of the virus has challenged their efficacy. In particular, the emerging variants B.1.1.7, B.1.3...

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Veröffentlicht in:	Nature (London) 2021-07, Vol.595 (7866), p.278-282
Hauptverfasser:	Xu, Jianliang, Xu, Kai, Jung, Seolkyoung, Conte, Andrea, Lieberman, Jenna, Muecksch, Frauke, Lorenzi, Julio Cesar Cetrulo, Park, Solji, Schmidt, Fabian, Wang, Zijun, Huang, Yaoxing, Luo, Yang, Nair, Manoj S., Wang, Pengfei, Schulz, Jonathan E., Tessarollo, Lino, Bylund, Tatsiana, Chuang, Gwo-Yu, Olia, Adam S., Stephens, Tyler, Teng, I-Ting, Tsybovsky, Yaroslav, Zhou, Tongqing, Munster, Vincent, Ho, David D., Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., Kwong, Peter D., Casellas, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 101/28 13/1 38/39 45/23 45/41 631/250/2499 631/250/255 631/326/596/4130 82/83 ACE2 Angiotensin-converting enzyme 2 Animals Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antibodies, Neutralizing - isolation & purification Antigenic drift Antigens Avidity Binding Bone marrow Camelids, New World - genetics Camelids, New World - immunology Camels Chains Cloning Coronaviruses COVID-19 COVID-19 vaccines CRISPR-Cas Systems Disease transmission Domains Epitopes Female Gene Editing Genes HIV Human immunodeficiency virus Humanities and Social Sciences Humans Immunotherapy Interferometry Male Mice Mice, Inbred C57BL Models, Molecular multidisciplinary Mutation Nanobodies Neutralization Neutralization Tests Pandemics SARS-CoV-2 - chemistry SARS-CoV-2 - genetics SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Single-Domain Antibodies - chemistry Single-Domain Antibodies - genetics Single-Domain Antibodies - immunology Single-Domain Antibodies - isolation & purification Somatic Hypermutation, Immunoglobulin - genetics Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology Stem cells Vaccines Viral diseases
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