PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer
Background. PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear. Methods. PLOD2 expression and CESC patients’ survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier...
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| description | Background. PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear. Methods. PLOD2 expression and CESC patients’ survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression of PLOD2 in CESC; Gene Set Enrichment Analysis was performed using the STRING and DAVID databases; and the correlations between PLOD2 and cancer immune infiltrates were investigated using the TIMER and TISIDB databases. Results. We found that the expression level of PLOD2 was increased in various cancers, and meta-analysis in the Oncomine database revealed that PLOD2 was significantly upregulated in CESC compared to that in normal tissues (P |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8260295</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A696882893</galeid><sourcerecordid>A696882893</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-304ab0eb6b098f0fd279fca7035f63b53da715aca793b8c2decee1a80234f89e3</originalsourceid><addsrcrecordid>eNp9ks1r2zAYxsXYWEvb285DsMtgTasPy5Yvg5B9BVKaw3adeC3LiTpbaiW5Zf99ZZJlWw_VRUL68YjneR-E3lByQakQl4wweikEZbwgL9Ax47SYlbSgLw9nzo_QWYw3JC9JS1KXr9ERL5iQrOTH6Od6df2J4WXEgNc-GZfwOviN8zFZja8g_DIBg2vxPEavLSQT8YNNW7wchtEZvHSd7VOAZL3D1uGFCfdWQ48X4LQJp-hVB300Z_v9BP348vn74ttsdf11uZivZlqQIs04KaAhpikbUsuOdC2r6k5DRbjoSt4I3kJFBeSbmjdSs9ZoYyhIkn13sjb8BH3c6d6OzWBanX0E6NVtsAOE38qDVf-_OLtVG3-vcgqE1SILvN8LBH83mpjUYKM2fQ_O-DEqlkMWkrJyQt89QW_8GFy2N1GEVpxWxV9qA71R1nU-_6snUTUv61JKJmv-PCV5HlLBZabOd5QOPsZguoMxStTUAzX1QO17kPG3_4ZxgP9MPQMfdsDWuhYe7PNyj7g6t2o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2550173174</pqid></control><display><type>article</type><title>PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Li, Guang ; Wang, Xuefeng ; Liu, Guobing</creator><contributor>Todorov, Plamen ; Plamen Todorov</contributor><creatorcontrib>Li, Guang ; Wang, Xuefeng ; Liu, Guobing ; Todorov, Plamen ; Plamen Todorov</creatorcontrib><description>Background. PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear. Methods. PLOD2 expression and CESC patients’ survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression of PLOD2 in CESC; Gene Set Enrichment Analysis was performed using the STRING and DAVID databases; and the correlations between PLOD2 and cancer immune infiltrates were investigated using the TIMER and TISIDB databases. Results. We found that the expression level of PLOD2 was increased in various cancers, and meta-analysis in the Oncomine database revealed that PLOD2 was significantly upregulated in CESC compared to that in normal tissues (P<0.001). In addition, the high expression of PLOD2 was closely related to poor overall survival (OS) and disease-free survival (DFS) in patients with CESC (OS HR=1.73, P=0.029; DFS HR=2.60, P=0.018). Functional annotations indicated that differentially expressed PLOD2 were primarily related to protein digestion and absorption pathways and to the collagen fibril organization process. Immune infiltration analysis showed that PLOD2 was highly correlated with B cells, CD4+ T cells, T helper type 2 (Th2) cells, and eosinophils in CESC. Conclusion. PLOD2 is positively associated with poor prognosis and might be considered a novel diagnostic and prognostic marker for CESC patients.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/5512340</identifier><identifier>PMID: 34258263</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Analysis ; Annotations ; Bioinformatics ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cancer ; CD4 antigen ; Cervical cancer ; Cervix ; Collagen ; Eosinophils ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Gene set enrichment analysis ; Genetic aspects ; Helper cells ; Humans ; Hydroxylases ; Identification and classification ; Immunohistochemistry ; Infiltration ; Leukocytes (eosinophilic) ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Lymphocytes, Tumor-Infiltrating - immunology ; Lymphocytes, Tumor-Infiltrating - pathology ; Markers ; Medical prognosis ; Metastases ; Molecular Sequence Annotation ; Multivariate Analysis ; Patients ; Physiological aspects ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - genetics ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - metabolism ; Prognosis ; Proportional Hazards Models ; Protein Interaction Maps - genetics ; Proteins ; Signal Transduction ; Statistics, Nonparametric ; Survival ; Survival analysis ; Tumorigenesis ; Tumors ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - immunology ; Uterine Cervical Neoplasms - pathology</subject><ispartof>BioMed research international, 2021, Vol.2021 (1), p.5512340-5512340</ispartof><rights>Copyright © 2021 Guang Li et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Guang Li et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Guang Li et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-304ab0eb6b098f0fd279fca7035f63b53da715aca793b8c2decee1a80234f89e3</citedby><cites>FETCH-LOGICAL-c504t-304ab0eb6b098f0fd279fca7035f63b53da715aca793b8c2decee1a80234f89e3</cites><orcidid>0000-0002-3150-0791 ; 0000-0003-2824-3410 ; 0000-0003-2455-9442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260295/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260295/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4009,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34258263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Todorov, Plamen</contributor><contributor>Plamen Todorov</contributor><creatorcontrib>Li, Guang</creatorcontrib><creatorcontrib>Wang, Xuefeng</creatorcontrib><creatorcontrib>Liu, Guobing</creatorcontrib><title>PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear. Methods. PLOD2 expression and CESC patients’ survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression of PLOD2 in CESC; Gene Set Enrichment Analysis was performed using the STRING and DAVID databases; and the correlations between PLOD2 and cancer immune infiltrates were investigated using the TIMER and TISIDB databases. Results. We found that the expression level of PLOD2 was increased in various cancers, and meta-analysis in the Oncomine database revealed that PLOD2 was significantly upregulated in CESC compared to that in normal tissues (P<0.001). In addition, the high expression of PLOD2 was closely related to poor overall survival (OS) and disease-free survival (DFS) in patients with CESC (OS HR=1.73, P=0.029; DFS HR=2.60, P=0.018). Functional annotations indicated that differentially expressed PLOD2 were primarily related to protein digestion and absorption pathways and to the collagen fibril organization process. Immune infiltration analysis showed that PLOD2 was highly correlated with B cells, CD4+ T cells, T helper type 2 (Th2) cells, and eosinophils in CESC. Conclusion. PLOD2 is positively associated with poor prognosis and might be considered a novel diagnostic and prognostic marker for CESC patients.</description><subject>Analysis</subject><subject>Annotations</subject><subject>Bioinformatics</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>CD4 antigen</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Collagen</subject><subject>Eosinophils</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Ontology</subject><subject>Gene set enrichment analysis</subject><subject>Genetic aspects</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Hydroxylases</subject><subject>Identification and classification</subject><subject>Immunohistochemistry</subject><subject>Infiltration</subject><subject>Leukocytes (eosinophilic)</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Lymphocytes, Tumor-Infiltrating - immunology</subject><subject>Lymphocytes, Tumor-Infiltrating - pathology</subject><subject>Markers</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Molecular Sequence Annotation</subject><subject>Multivariate Analysis</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - genetics</subject><subject>Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - metabolism</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Protein Interaction Maps - genetics</subject><subject>Proteins</subject><subject>Signal Transduction</subject><subject>Statistics, Nonparametric</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - immunology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1r2zAYxsXYWEvb285DsMtgTasPy5Yvg5B9BVKaw3adeC3LiTpbaiW5Zf99ZZJlWw_VRUL68YjneR-E3lByQakQl4wweikEZbwgL9Ax47SYlbSgLw9nzo_QWYw3JC9JS1KXr9ERL5iQrOTH6Od6df2J4WXEgNc-GZfwOviN8zFZja8g_DIBg2vxPEavLSQT8YNNW7wchtEZvHSd7VOAZL3D1uGFCfdWQ48X4LQJp-hVB300Z_v9BP348vn74ttsdf11uZivZlqQIs04KaAhpikbUsuOdC2r6k5DRbjoSt4I3kJFBeSbmjdSs9ZoYyhIkn13sjb8BH3c6d6OzWBanX0E6NVtsAOE38qDVf-_OLtVG3-vcgqE1SILvN8LBH83mpjUYKM2fQ_O-DEqlkMWkrJyQt89QW_8GFy2N1GEVpxWxV9qA71R1nU-_6snUTUv61JKJmv-PCV5HlLBZabOd5QOPsZguoMxStTUAzX1QO17kPG3_4ZxgP9MPQMfdsDWuhYe7PNyj7g6t2o</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Li, Guang</creator><creator>Wang, Xuefeng</creator><creator>Liu, Guobing</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3150-0791</orcidid><orcidid>https://orcid.org/0000-0003-2824-3410</orcidid><orcidid>https://orcid.org/0000-0003-2455-9442</orcidid></search><sort><creationdate>2021</creationdate><title>PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer</title><author>Li, Guang ; Wang, Xuefeng ; Liu, Guobing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-304ab0eb6b098f0fd279fca7035f63b53da715aca793b8c2decee1a80234f89e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Annotations</topic><topic>Bioinformatics</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>CD4 antigen</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Collagen</topic><topic>Eosinophils</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Ontology</topic><topic>Gene set enrichment analysis</topic><topic>Genetic aspects</topic><topic>Helper cells</topic><topic>Humans</topic><topic>Hydroxylases</topic><topic>Identification and classification</topic><topic>Immunohistochemistry</topic><topic>Infiltration</topic><topic>Leukocytes (eosinophilic)</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Lymphocytes, Tumor-Infiltrating - immunology</topic><topic>Lymphocytes, Tumor-Infiltrating - pathology</topic><topic>Markers</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Molecular Sequence Annotation</topic><topic>Multivariate Analysis</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - genetics</topic><topic>Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - metabolism</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Protein Interaction Maps - genetics</topic><topic>Proteins</topic><topic>Signal Transduction</topic><topic>Statistics, Nonparametric</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - immunology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Guang</creatorcontrib><creatorcontrib>Wang, Xuefeng</creatorcontrib><creatorcontrib>Liu, Guobing</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Guang</au><au>Wang, Xuefeng</au><au>Liu, Guobing</au><au>Todorov, Plamen</au><au>Plamen Todorov</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>5512340</spage><epage>5512340</epage><pages>5512340-5512340</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear. Methods. PLOD2 expression and CESC patients’ survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression of PLOD2 in CESC; Gene Set Enrichment Analysis was performed using the STRING and DAVID databases; and the correlations between PLOD2 and cancer immune infiltrates were investigated using the TIMER and TISIDB databases. Results. We found that the expression level of PLOD2 was increased in various cancers, and meta-analysis in the Oncomine database revealed that PLOD2 was significantly upregulated in CESC compared to that in normal tissues (P<0.001). In addition, the high expression of PLOD2 was closely related to poor overall survival (OS) and disease-free survival (DFS) in patients with CESC (OS HR=1.73, P=0.029; DFS HR=2.60, P=0.018). Functional annotations indicated that differentially expressed PLOD2 were primarily related to protein digestion and absorption pathways and to the collagen fibril organization process. Immune infiltration analysis showed that PLOD2 was highly correlated with B cells, CD4+ T cells, T helper type 2 (Th2) cells, and eosinophils in CESC. Conclusion. PLOD2 is positively associated with poor prognosis and might be considered a novel diagnostic and prognostic marker for CESC patients.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34258263</pmid><doi>10.1155/2021/5512340</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3150-0791</orcidid><orcidid>https://orcid.org/0000-0003-2824-3410</orcidid><orcidid>https://orcid.org/0000-0003-2455-9442</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Annotations Bioinformatics Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer CD4 antigen Cervical cancer Cervix Collagen Eosinophils Female Gene expression Gene Expression Regulation, Neoplastic Gene Ontology Gene set enrichment analysis Genetic aspects Helper cells Humans Hydroxylases Identification and classification Immunohistochemistry Infiltration Leukocytes (eosinophilic) Lymphocytes Lymphocytes B Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Markers Medical prognosis Metastases Molecular Sequence Annotation Multivariate Analysis Patients Physiological aspects Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - genetics Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - metabolism Prognosis Proportional Hazards Models Protein Interaction Maps - genetics Proteins Signal Transduction Statistics, Nonparametric Survival Survival analysis Tumorigenesis Tumors Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - pathology |
| title | PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer |
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