Neural Epidermal Growth Factor-Like 1 Protein-Positive Membranous Nephropathy in Chinese Patients
The neural EGF-like 1 (NELL-1) protein is a novel antigen in primary membranous nephropathy. The prevalence and clinical characteristics of NELL-1-positive membranous nephropathy in Chinese individuals with primary membranous nephropathy are unclear. A total of 832 consecutive patients with biopsy-p...
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| Veröffentlicht in: | Clinical journal of the American Society of Nephrology 2021-05, Vol.16 (5), p.727-735 |
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| creator | Wang, Guoqin Sun, Lijun Dong, Hongrui Wang, Yanyan Xu, Xiaoyi Zhao, Zhirui Cheng, Wenrong Liu, Xuejiao Zhao, Xiaoyi Geng, Yanqiu Bao, Siqin Chen, Yipu Cheng, Hong |
| description | The neural EGF-like 1 (NELL-1) protein is a novel antigen in primary membranous nephropathy. The prevalence and clinical characteristics of NELL-1-positive membranous nephropathy in Chinese individuals with primary membranous nephropathy are unclear.
A total of 832 consecutive patients with biopsy-proven primary membranous nephropathy were enrolled. The glomerular expression of phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) was screened. Glomerular immunohistochemistry staining for NELL-1 was performed in 43 patients with PLA2R- and THSD7A-negative membranous nephropathy, 31 patients with PLA2R-positive membranous nephropathy, and two patients with PLA2R and THSD7A double positivity. The NELL-1 antibody was also detected in the sera of patients with NELL-1-positive membranous nephropathy by western blot. Clinical and pathologic features were comparable between patients with isolated NELL-1-positive, isolated PLA2R/THSD7A-positive, and triple antigen-negative membranous nephropathy.
Among the 832 patients with primary membranous nephropathy, 11 of 54 (20%) patients with PLA2R-negative membranous nephropathy had THSD7A-positive membranous nephropathy. NELL-1-positive membranous nephropathy accounted for 35% (15 of 43) of all patients with PLA2R- and THSD7A-negative membranous nephropathy. One patient was double positive for NELL-1 and PLA2R in glomerular deposits and positive for only the PLA2R antibody in the serum. Most patients with NELL-1-positive membranous nephropathy were women. No tumors were found. There were significant differences in the prevalence of IgG subtypes between patients with different antigen positivity. Among patients with isolated NELL-1-positive membranous nephropathy, although 80% (12 of 15) were IgG4 staining positive, the proportion of IgG4 dominance was only 67% (ten of 15).
About one third of patients who were PLA2R and THSD7A negative were NELL-1 positive in Chinese patients with primary membranous nephropathy. NELL-1-positive membranous nephropathy was more common than THSD7A-positive membranous nephropathy in PLA2R-negative membranous nephropathy. |
| doi_str_mv | 10.2215/CJN.11860720 |
| format | Article |
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A total of 832 consecutive patients with biopsy-proven primary membranous nephropathy were enrolled. The glomerular expression of phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) was screened. Glomerular immunohistochemistry staining for NELL-1 was performed in 43 patients with PLA2R- and THSD7A-negative membranous nephropathy, 31 patients with PLA2R-positive membranous nephropathy, and two patients with PLA2R and THSD7A double positivity. The NELL-1 antibody was also detected in the sera of patients with NELL-1-positive membranous nephropathy by western blot. Clinical and pathologic features were comparable between patients with isolated NELL-1-positive, isolated PLA2R/THSD7A-positive, and triple antigen-negative membranous nephropathy.
Among the 832 patients with primary membranous nephropathy, 11 of 54 (20%) patients with PLA2R-negative membranous nephropathy had THSD7A-positive membranous nephropathy. NELL-1-positive membranous nephropathy accounted for 35% (15 of 43) of all patients with PLA2R- and THSD7A-negative membranous nephropathy. One patient was double positive for NELL-1 and PLA2R in glomerular deposits and positive for only the PLA2R antibody in the serum. Most patients with NELL-1-positive membranous nephropathy were women. No tumors were found. There were significant differences in the prevalence of IgG subtypes between patients with different antigen positivity. Among patients with isolated NELL-1-positive membranous nephropathy, although 80% (12 of 15) were IgG4 staining positive, the proportion of IgG4 dominance was only 67% (ten of 15).
About one third of patients who were PLA2R and THSD7A negative were NELL-1 positive in Chinese patients with primary membranous nephropathy. NELL-1-positive membranous nephropathy was more common than THSD7A-positive membranous nephropathy in PLA2R-negative membranous nephropathy.</description><identifier>ISSN: 1555-9041</identifier><identifier>EISSN: 1555-905X</identifier><identifier>DOI: 10.2215/CJN.11860720</identifier><identifier>PMID: 33849930</identifier><language>eng</language><publisher>United States: American Society of Nephrology</publisher><subject>Adult ; Asian People ; EGF Family of Proteins - analysis ; Female ; Glomerulonephritis, Membranous - pathology ; Humans ; Kidney - chemistry ; Male ; Middle Aged ; Original ; Retrospective Studies</subject><ispartof>Clinical journal of the American Society of Nephrology, 2021-05, Vol.16 (5), p.727-735</ispartof><rights>Copyright © 2021 by the American Society of Nephrology.</rights><rights>Copyright © 2021 by the American Society of Nephrology 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-3f45e995344a3dd4d5367bf54901b15a34d98a28e793e4da6a24990e70e40e263</citedby><cites>FETCH-LOGICAL-c493t-3f45e995344a3dd4d5367bf54901b15a34d98a28e793e4da6a24990e70e40e263</cites><orcidid>0000-0002-7908-3333</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259482/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259482/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33849930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Guoqin</creatorcontrib><creatorcontrib>Sun, Lijun</creatorcontrib><creatorcontrib>Dong, Hongrui</creatorcontrib><creatorcontrib>Wang, Yanyan</creatorcontrib><creatorcontrib>Xu, Xiaoyi</creatorcontrib><creatorcontrib>Zhao, Zhirui</creatorcontrib><creatorcontrib>Cheng, Wenrong</creatorcontrib><creatorcontrib>Liu, Xuejiao</creatorcontrib><creatorcontrib>Zhao, Xiaoyi</creatorcontrib><creatorcontrib>Geng, Yanqiu</creatorcontrib><creatorcontrib>Bao, Siqin</creatorcontrib><creatorcontrib>Chen, Yipu</creatorcontrib><creatorcontrib>Cheng, Hong</creatorcontrib><title>Neural Epidermal Growth Factor-Like 1 Protein-Positive Membranous Nephropathy in Chinese Patients</title><title>Clinical journal of the American Society of Nephrology</title><addtitle>Clin J Am Soc Nephrol</addtitle><description>The neural EGF-like 1 (NELL-1) protein is a novel antigen in primary membranous nephropathy. The prevalence and clinical characteristics of NELL-1-positive membranous nephropathy in Chinese individuals with primary membranous nephropathy are unclear.
A total of 832 consecutive patients with biopsy-proven primary membranous nephropathy were enrolled. The glomerular expression of phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) was screened. Glomerular immunohistochemistry staining for NELL-1 was performed in 43 patients with PLA2R- and THSD7A-negative membranous nephropathy, 31 patients with PLA2R-positive membranous nephropathy, and two patients with PLA2R and THSD7A double positivity. The NELL-1 antibody was also detected in the sera of patients with NELL-1-positive membranous nephropathy by western blot. Clinical and pathologic features were comparable between patients with isolated NELL-1-positive, isolated PLA2R/THSD7A-positive, and triple antigen-negative membranous nephropathy.
Among the 832 patients with primary membranous nephropathy, 11 of 54 (20%) patients with PLA2R-negative membranous nephropathy had THSD7A-positive membranous nephropathy. NELL-1-positive membranous nephropathy accounted for 35% (15 of 43) of all patients with PLA2R- and THSD7A-negative membranous nephropathy. One patient was double positive for NELL-1 and PLA2R in glomerular deposits and positive for only the PLA2R antibody in the serum. Most patients with NELL-1-positive membranous nephropathy were women. No tumors were found. There were significant differences in the prevalence of IgG subtypes between patients with different antigen positivity. Among patients with isolated NELL-1-positive membranous nephropathy, although 80% (12 of 15) were IgG4 staining positive, the proportion of IgG4 dominance was only 67% (ten of 15).
About one third of patients who were PLA2R and THSD7A negative were NELL-1 positive in Chinese patients with primary membranous nephropathy. NELL-1-positive membranous nephropathy was more common than THSD7A-positive membranous nephropathy in PLA2R-negative membranous nephropathy.</description><subject>Adult</subject><subject>Asian People</subject><subject>EGF Family of Proteins - analysis</subject><subject>Female</subject><subject>Glomerulonephritis, Membranous - pathology</subject><subject>Humans</subject><subject>Kidney - chemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Retrospective Studies</subject><issn>1555-9041</issn><issn>1555-905X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtPwzAQhC0E4n3jjHzkQMDPJr4goarloVJ6AImb5SZbYmjiYDug_nuMgApOO9J-mt3RIHREyRljVJ4Pb6dnlBYDkjOygXaplDJTRD5trrWgO2gvhBdChOBMbqMdzguhFCe7yEyh92aJR52twDdJXXn3EWs8NmV0PpvYV8AUz7yLYNts5oKN9h3wHTRzb1rXBzyFrvauM7FeYdviYW1bCIBnJlpoYzhAWwuzDHD4M_fR43j0MLzOJvdXN8PLSVYKxWPGF0KCUpILYXhViUryQT5fSKEInVNpuKhUYVgBueIgKjMwLEUgkBMQBNiA76OLb9-unzdQlel2CqY7bxvjV9oZq_9vWlvrZ_euCyaVKFgyOPkx8O6thxB1Y0MJy6VpIeXUTFKWC8qZSujpN1p6F4KHxfoMJfqrFZ1a0b-tJPz472tr-LcG_gkgCoip</recordid><startdate>20210508</startdate><enddate>20210508</enddate><creator>Wang, Guoqin</creator><creator>Sun, Lijun</creator><creator>Dong, Hongrui</creator><creator>Wang, Yanyan</creator><creator>Xu, Xiaoyi</creator><creator>Zhao, Zhirui</creator><creator>Cheng, Wenrong</creator><creator>Liu, Xuejiao</creator><creator>Zhao, Xiaoyi</creator><creator>Geng, Yanqiu</creator><creator>Bao, Siqin</creator><creator>Chen, Yipu</creator><creator>Cheng, Hong</creator><general>American Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7908-3333</orcidid></search><sort><creationdate>20210508</creationdate><title>Neural Epidermal Growth Factor-Like 1 Protein-Positive Membranous Nephropathy in Chinese Patients</title><author>Wang, Guoqin ; Sun, Lijun ; Dong, Hongrui ; Wang, Yanyan ; Xu, Xiaoyi ; Zhao, Zhirui ; Cheng, Wenrong ; Liu, Xuejiao ; Zhao, Xiaoyi ; Geng, Yanqiu ; Bao, Siqin ; Chen, Yipu ; Cheng, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-3f45e995344a3dd4d5367bf54901b15a34d98a28e793e4da6a24990e70e40e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Asian People</topic><topic>EGF Family of Proteins - analysis</topic><topic>Female</topic><topic>Glomerulonephritis, Membranous - pathology</topic><topic>Humans</topic><topic>Kidney - chemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Guoqin</creatorcontrib><creatorcontrib>Sun, Lijun</creatorcontrib><creatorcontrib>Dong, Hongrui</creatorcontrib><creatorcontrib>Wang, Yanyan</creatorcontrib><creatorcontrib>Xu, Xiaoyi</creatorcontrib><creatorcontrib>Zhao, Zhirui</creatorcontrib><creatorcontrib>Cheng, Wenrong</creatorcontrib><creatorcontrib>Liu, Xuejiao</creatorcontrib><creatorcontrib>Zhao, Xiaoyi</creatorcontrib><creatorcontrib>Geng, Yanqiu</creatorcontrib><creatorcontrib>Bao, Siqin</creatorcontrib><creatorcontrib>Chen, Yipu</creatorcontrib><creatorcontrib>Cheng, Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Guoqin</au><au>Sun, Lijun</au><au>Dong, Hongrui</au><au>Wang, Yanyan</au><au>Xu, Xiaoyi</au><au>Zhao, Zhirui</au><au>Cheng, Wenrong</au><au>Liu, Xuejiao</au><au>Zhao, Xiaoyi</au><au>Geng, Yanqiu</au><au>Bao, Siqin</au><au>Chen, Yipu</au><au>Cheng, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural Epidermal Growth Factor-Like 1 Protein-Positive Membranous Nephropathy in Chinese Patients</atitle><jtitle>Clinical journal of the American Society of Nephrology</jtitle><addtitle>Clin J Am Soc Nephrol</addtitle><date>2021-05-08</date><risdate>2021</risdate><volume>16</volume><issue>5</issue><spage>727</spage><epage>735</epage><pages>727-735</pages><issn>1555-9041</issn><eissn>1555-905X</eissn><abstract>The neural EGF-like 1 (NELL-1) protein is a novel antigen in primary membranous nephropathy. The prevalence and clinical characteristics of NELL-1-positive membranous nephropathy in Chinese individuals with primary membranous nephropathy are unclear.
A total of 832 consecutive patients with biopsy-proven primary membranous nephropathy were enrolled. The glomerular expression of phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) was screened. Glomerular immunohistochemistry staining for NELL-1 was performed in 43 patients with PLA2R- and THSD7A-negative membranous nephropathy, 31 patients with PLA2R-positive membranous nephropathy, and two patients with PLA2R and THSD7A double positivity. The NELL-1 antibody was also detected in the sera of patients with NELL-1-positive membranous nephropathy by western blot. Clinical and pathologic features were comparable between patients with isolated NELL-1-positive, isolated PLA2R/THSD7A-positive, and triple antigen-negative membranous nephropathy.
Among the 832 patients with primary membranous nephropathy, 11 of 54 (20%) patients with PLA2R-negative membranous nephropathy had THSD7A-positive membranous nephropathy. NELL-1-positive membranous nephropathy accounted for 35% (15 of 43) of all patients with PLA2R- and THSD7A-negative membranous nephropathy. One patient was double positive for NELL-1 and PLA2R in glomerular deposits and positive for only the PLA2R antibody in the serum. Most patients with NELL-1-positive membranous nephropathy were women. No tumors were found. There were significant differences in the prevalence of IgG subtypes between patients with different antigen positivity. Among patients with isolated NELL-1-positive membranous nephropathy, although 80% (12 of 15) were IgG4 staining positive, the proportion of IgG4 dominance was only 67% (ten of 15).
About one third of patients who were PLA2R and THSD7A negative were NELL-1 positive in Chinese patients with primary membranous nephropathy. NELL-1-positive membranous nephropathy was more common than THSD7A-positive membranous nephropathy in PLA2R-negative membranous nephropathy.</abstract><cop>United States</cop><pub>American Society of Nephrology</pub><pmid>33849930</pmid><doi>10.2215/CJN.11860720</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7908-3333</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Asian People EGF Family of Proteins - analysis Female Glomerulonephritis, Membranous - pathology Humans Kidney - chemistry Male Middle Aged Original Retrospective Studies |
| title | Neural Epidermal Growth Factor-Like 1 Protein-Positive Membranous Nephropathy in Chinese Patients |
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