The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets With Different Outcomes
Exostosin (EXT) 1 and EXT2 proteins are recently discovered major components of the subepithelial deposits in a subset of patients with membranous nephropathy (MN).1,2 Although the detection of EXT1/2 seems to be a distinctive feature of MN related to systemic lupus erythematosus (SLE),1 the exact f...
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| Veröffentlicht in: | Kidney international reports 2021-07, Vol.6 (7), p.1977-1980 |
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| container_end_page | 1980 |
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| container_issue | 7 |
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| container_title | Kidney international reports |
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| creator | Saïdi, Michèle Brochériou, Isabelle Estève, Emmanuel Tuffet, Sophie Amoura, Zahir Miyara, Makoto Belenfant, Xavier Ulinski, Tim Rouvier, Philippe Debiec, Hanna Ronco, Pierre Buob, David |
| description | Exostosin (EXT) 1 and EXT2 proteins are recently discovered major components of the subepithelial deposits in a subset of patients with membranous nephropathy (MN).1,2 Although the detection of EXT1/2 seems to be a distinctive feature of MN related to systemic lupus erythematosus (SLE),1 the exact frequency of EXT-positive, SLE-associated MN (SLE-MN) and its potential clinical significance are not well determined.Here, we retrospectively evaluated 86 consecutive patients with biopsy-proven pure class 5 SLE-MN diagnosed between January 2010 and December 2018 in 2 nephropathology centers (La Pitié Salpêtrière and Tenon hospitals) in Paris, France; mixed classes (3 + 5 and 4 + 5 of the 2003 ISN/Renal Pathology Society classification)3 were excluded. |
| doi_str_mv | 10.1016/j.ekir.2021.04.025 |
| format | Article |
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mixed classes (3 + 5 and 4 + 5 of the 2003 ISN/Renal Pathology Society classification)3 were excluded.</description><subject>Adaptive immunology</subject><subject>exostosin</subject><subject>Human health and pathology</subject><subject>immunohistochemistry</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>membranous nephropathy</subject><subject>renal biopsy</subject><subject>Research Letter</subject><subject>systemic lupus erythematosus</subject><subject>Urology and Nephrology</subject><issn>2468-0249</issn><issn>2468-0249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAQhiMEolXpC3DKEQ4bxo7j2BJCqtpCK23poUUcLceZEC9JHGxnRd8eR1sB5cDJ45n5_hnNn2WvCRQECH-3K_C79QUFSgpgBdDqWXZMGRcboEw-_ys-yk5D2AEAqXklQbzMjkpWQi1leZzF-x7zy58uRBfslF-P4zK53qav6XG0Rg_5XdRxCfmF7Tr0OEWrI4Z8u8wpeYNj4_XkUvgZ5967Wcf-Ib9bmoAx5F9t7P-A-e0SjRsxvMpedHoIePr4nmRfPl7en19ttrefrs_PthvDOI8bQUAwIIKauiVN2xkGFRouKLQgJUdSN9DQhlQlE4aWupZIQNY1r4nkwEh5kn046M5LM2Jr0g5eD2r2dtT-QTlt1dPKZHv1ze2VoJVgkieBtweB_h_s6myr1hyUZVlVQuzXYW8eh3n3Y8EQ1WiDwWHQE6b7KFpVaVHGqrWVHlqNdyF47H5rE1Cru2qnVnfV6q4CppK7CXp_gDBdbG_Rq2AsTgZb69FE1Tr7P_wX3CutnA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Saïdi, Michèle</creator><creator>Brochériou, Isabelle</creator><creator>Estève, Emmanuel</creator><creator>Tuffet, Sophie</creator><creator>Amoura, Zahir</creator><creator>Miyara, Makoto</creator><creator>Belenfant, Xavier</creator><creator>Ulinski, Tim</creator><creator>Rouvier, Philippe</creator><creator>Debiec, Hanna</creator><creator>Ronco, Pierre</creator><creator>Buob, David</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2792-9883</orcidid></search><sort><creationdate>20210701</creationdate><title>The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets With Different Outcomes</title><author>Saïdi, Michèle ; Brochériou, Isabelle ; Estève, Emmanuel ; Tuffet, Sophie ; Amoura, Zahir ; Miyara, Makoto ; Belenfant, Xavier ; Ulinski, Tim ; Rouvier, Philippe ; Debiec, Hanna ; Ronco, Pierre ; Buob, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-810840182c7d1bdfc405ec6820d0996e17b0b2b15348c23a79e10977671960413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptive immunology</topic><topic>exostosin</topic><topic>Human health and pathology</topic><topic>immunohistochemistry</topic><topic>Immunology</topic><topic>Life Sciences</topic><topic>membranous nephropathy</topic><topic>renal biopsy</topic><topic>Research Letter</topic><topic>systemic lupus erythematosus</topic><topic>Urology and Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saïdi, Michèle</creatorcontrib><creatorcontrib>Brochériou, Isabelle</creatorcontrib><creatorcontrib>Estève, Emmanuel</creatorcontrib><creatorcontrib>Tuffet, Sophie</creatorcontrib><creatorcontrib>Amoura, Zahir</creatorcontrib><creatorcontrib>Miyara, Makoto</creatorcontrib><creatorcontrib>Belenfant, Xavier</creatorcontrib><creatorcontrib>Ulinski, Tim</creatorcontrib><creatorcontrib>Rouvier, Philippe</creatorcontrib><creatorcontrib>Debiec, Hanna</creatorcontrib><creatorcontrib>Ronco, Pierre</creatorcontrib><creatorcontrib>Buob, David</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Kidney international reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saïdi, Michèle</au><au>Brochériou, Isabelle</au><au>Estève, Emmanuel</au><au>Tuffet, Sophie</au><au>Amoura, Zahir</au><au>Miyara, Makoto</au><au>Belenfant, Xavier</au><au>Ulinski, Tim</au><au>Rouvier, Philippe</au><au>Debiec, Hanna</au><au>Ronco, Pierre</au><au>Buob, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets With Different Outcomes</atitle><jtitle>Kidney international reports</jtitle><date>2021-07-01</date><risdate>2021</risdate><volume>6</volume><issue>7</issue><spage>1977</spage><epage>1980</epage><pages>1977-1980</pages><issn>2468-0249</issn><eissn>2468-0249</eissn><abstract>Exostosin (EXT) 1 and EXT2 proteins are recently discovered major components of the subepithelial deposits in a subset of patients with membranous nephropathy (MN).1,2 Although the detection of EXT1/2 seems to be a distinctive feature of MN related to systemic lupus erythematosus (SLE),1 the exact frequency of EXT-positive, SLE-associated MN (SLE-MN) and its potential clinical significance are not well determined.Here, we retrospectively evaluated 86 consecutive patients with biopsy-proven pure class 5 SLE-MN diagnosed between January 2010 and December 2018 in 2 nephropathology centers (La Pitié Salpêtrière and Tenon hospitals) in Paris, France; 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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adaptive immunology exostosin Human health and pathology immunohistochemistry Immunology Life Sciences membranous nephropathy renal biopsy Research Letter systemic lupus erythematosus Urology and Nephrology |
| title | The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets With Different Outcomes |
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