Metaplastic Effects of Ketamine and MK-801 on Glutamate Receptors Expression in Rat Medial Prefrontal Cortex and Hippocampus

Ketamine and MK-801 by blocking NMDA receptors may induce reinforcing effects as well as schizophrenia-like symptoms. Recent results showed that ketamine can also effectively reverse depressive signs in patients’ refractory to standard therapies. This evidence clearly points to the need of character...

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Veröffentlicht in:	Molecular neurobiology 2021-07, Vol.58 (7), p.3443-3456
Hauptverfasser:	Piva, Alessandro, Caffino, Lucia, Mottarlini, Francesca, Pintori, Nicholas, Castillo Díaz, Fernando, Fumagalli, Fabio, Chiamulera, Cristiano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonists Biomedical and Life Sciences Biomedicine Cell Biology Dizocilpine Dizocilpine Maleate - pharmacology Excitability Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Transporter 2 - biosynthesis Gene Expression Glutamate receptors Glutamatergic transmission Glutamic acid receptors (ionotropic) Glutamic acid transporter Hippocampus Hippocampus - drug effects Hippocampus - metabolism Ketamine Ketamine - pharmacology Male Mental disorders Mood N-Methyl-D-aspartic acid receptors Neurobiology Neurology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurosciences Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Proteins Rats Rats, Sprague-Dawley Receptors, Glutamate - biosynthesis Schizophrenia Synapses Synaptic density Synaptic plasticity α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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