Water as a Good Solvent for Unfolded Proteins: Folding and Collapse are Fundamentally Different

The argument that the hydrophobic effect is the primary effect driving the folding of globular proteins is nearly universally accepted (including by the authors). But does this view also imply that water is a “poor” solvent for the unfolded states of these same proteins? Here we argue that the answe...

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Veröffentlicht in:	Journal of molecular biology 2020-04, Vol.432 (9), p.2882-2889
Hauptverfasser:	Clark, Patricia L., Plaxco, Kevin W., Sosnick, Tobin R.
Format:	Artikel
Sprache:	eng
Schlagworte:	collapse denatured state flory exponent protein folding small-angle scattering
Online-Zugang:	Volltext
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