Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells

The WNT signaling system plays an important but paradoxical role in the regulation of pluripotency. In the cow, IWR-1, which inhibits canonical WNT activation and has WNT-independent actions, promotes the derivation of primed pluripotent embryonic stem cells from the blastocyst. Here, we describe a...

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Veröffentlicht in:	Biology of reproduction 2021-07, Vol.105 (1), p.52-63
Hauptverfasser:	Xiao, Yao, Amaral, Thiago F., Ross, Pablo J., Soto, Delia A., Diffenderfer, Kenneth E., Pankonin, Aimee R., Jeensuk, Surawich, Tríbulo, Paula, Hansen, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - metabolism Blastocysts bovine Cattle Cell differentiation Dkk1 protein Editor's Choice Embryo cells Embryonic stem cells Embryonic Stem Cells - metabolism Enzyme inhibitors Heterocyclic Compounds, 3-Ring - adverse effects JAK/STAT Janus kinase Pluripotency RESEARCH ARTICLE Scientific equipment and supplies industry Stat3 protein Stem cells Transcription WNT Wnt protein Wnt Signaling Pathway
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