Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites

Wnt signals bind to Frizzled receptors to trigger canonical and noncanonical signaling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed by the hub protein Dishevelled. During canonical (β-catenin–dependent) signaling, Dishevelled assembl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-06, Vol.118 (26), p.1-10
Hauptverfasser:	Beitia, Gonzalo J., Rutherford, Trevor J., Freund, Stefan M. V., Pelham, Hugh R., Bienz, Mariann, Gammons, Melissa V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Biological Sciences Conserved Sequence Dimerization Dimers Dishevelled protein Dishevelled Proteins - chemistry Dishevelled Proteins - genetics Dishevelled Proteins - metabolism Domains Frizzled protein Homeostasis Humans Kinases Magnetic resonance spectroscopy Models, Molecular Mutation Mutation - genetics NMR NMR spectroscopy Nuclear magnetic resonance Phosphorylation Pleckstrin Protein Domains Protein Multimerization Protein Stability Protein structure Serine - metabolism Signaling Signalosomes Structure-Activity Relationship Thermodynamics Wnt protein Wnt Signaling Pathway β-Catenin
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