PMS2: a potential prognostic protein marker in oral squamous cell carcinoma
An increase in oral squamous cell carcinoma (OSCC) cases was observed despite the reduction in exposure to classic risk factors. Although the exact cause of this trend remains unknown, epigenetic factors could be contributing to an increased occurrence of these tumors. This study aims to assess the...
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| Veröffentlicht in: | Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2021-07, Vol.26 (4), p.e451-e458 |
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| creator | Decker, J-M Filho, O-V Freitas, M-O Silva-Fernandes, I-J Dantas, T-S Campêlo, C-S Cunha, M-D Silva, P-G Sousa, F-B |
| description | An increase in oral squamous cell carcinoma (OSCC) cases was observed despite the reduction in exposure to classic risk factors. Although the exact cause of this trend remains unknown, epigenetic factors could be contributing to an increased occurrence of these tumors. This study aims to assess the influence of PMS2 protein immunoexpression on the prognosis of patients with OSCC.
This study comprised 76 cases of OSCC treated between 2011 and 2016. Immunohistochemical staining for PMS2 was performed. For evaluation, 10 fields per histological section were photographed at a 400x magnification and positively-stained cells were counted with Image J. Mann-Whitney and Kruskal-Wallis tests were used to compare the immunolabeling pattern with the clinical-pathological and prognostic characteristics. Survival analysis was performed with Chi-square, Long-Rank Mantel-Cox and Cox regression tests (p60%; p=0.041) were associated with low survival (p=0.029). In multivariate analysis, surgery combined with chemotherapy (p=0.030) and high PMS2 immunoexpression (p=0.042) significantly increased the risk of death for ≤60 years old patients.
The findings of this study indicate that PMS2 can be a potential prognostic protein marker in OSCC patients 60 years of age and younger. |
| doi_str_mv | 10.4317/medoral.24303 |
| format | Article |
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This study comprised 76 cases of OSCC treated between 2011 and 2016. Immunohistochemical staining for PMS2 was performed. For evaluation, 10 fields per histological section were photographed at a 400x magnification and positively-stained cells were counted with Image J. Mann-Whitney and Kruskal-Wallis tests were used to compare the immunolabeling pattern with the clinical-pathological and prognostic characteristics. Survival analysis was performed with Chi-square, Long-Rank Mantel-Cox and Cox regression tests (p<0.05).
An overexpression of PMS2 was observed in N0/1 tumors and in oral cancers found in unusual locations. In patients ≤60 years of age, high levels of PMS2 (>60%; p=0.041) were associated with low survival (p=0.029). In multivariate analysis, surgery combined with chemotherapy (p=0.030) and high PMS2 immunoexpression (p=0.042) significantly increased the risk of death for ≤60 years old patients.
The findings of this study indicate that PMS2 can be a potential prognostic protein marker in OSCC patients 60 years of age and younger.</description><identifier>ISSN: 1698-6946</identifier><identifier>ISSN: 1698-4447</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.24303</identifier><identifier>PMID: 33247565</identifier><language>eng</language><publisher>Spain: Medicina Oral S.L</publisher><subject>Biomarkers, Tumor ; Carcinoma, Squamous Cell - diagnosis ; Head and Neck Neoplasms ; Humans ; Immunohistochemistry ; Middle Aged ; Mismatch Repair Endonuclease PMS2 ; Mouth Neoplasms - diagnosis ; Prognosis ; Squamous Cell Carcinoma of Head and Neck</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2021-07, Vol.26 (4), p.e451-e458</ispartof><rights>Copyright: © 2021 Medicina Oral S.L. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-6592b901f408058516ac0d2963fd6feccee066c5ca2a6363fd70196af2f266173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254887/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254887/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33247565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Decker, J-M</creatorcontrib><creatorcontrib>Filho, O-V</creatorcontrib><creatorcontrib>Freitas, M-O</creatorcontrib><creatorcontrib>Silva-Fernandes, I-J</creatorcontrib><creatorcontrib>Dantas, T-S</creatorcontrib><creatorcontrib>Campêlo, C-S</creatorcontrib><creatorcontrib>Cunha, M-D</creatorcontrib><creatorcontrib>Silva, P-G</creatorcontrib><creatorcontrib>Sousa, F-B</creatorcontrib><title>PMS2: a potential prognostic protein marker in oral squamous cell carcinoma</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>An increase in oral squamous cell carcinoma (OSCC) cases was observed despite the reduction in exposure to classic risk factors. Although the exact cause of this trend remains unknown, epigenetic factors could be contributing to an increased occurrence of these tumors. This study aims to assess the influence of PMS2 protein immunoexpression on the prognosis of patients with OSCC.
This study comprised 76 cases of OSCC treated between 2011 and 2016. Immunohistochemical staining for PMS2 was performed. For evaluation, 10 fields per histological section were photographed at a 400x magnification and positively-stained cells were counted with Image J. Mann-Whitney and Kruskal-Wallis tests were used to compare the immunolabeling pattern with the clinical-pathological and prognostic characteristics. Survival analysis was performed with Chi-square, Long-Rank Mantel-Cox and Cox regression tests (p<0.05).
An overexpression of PMS2 was observed in N0/1 tumors and in oral cancers found in unusual locations. In patients ≤60 years of age, high levels of PMS2 (>60%; p=0.041) were associated with low survival (p=0.029). In multivariate analysis, surgery combined with chemotherapy (p=0.030) and high PMS2 immunoexpression (p=0.042) significantly increased the risk of death for ≤60 years old patients.
The findings of this study indicate that PMS2 can be a potential prognostic protein marker in OSCC patients 60 years of age and younger.</description><subject>Biomarkers, Tumor</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Middle Aged</subject><subject>Mismatch Repair Endonuclease PMS2</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Prognosis</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><issn>1698-6946</issn><issn>1698-4447</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUT1PwzAUtBCIlsLIijyypPjzJWFAQhVfoggkYLZc1ymBJG7tBIl_j0MLKl58ej7du_MhdEzJWHCantV27ryuxkxwwnfQkEKeJZAL2N3CA3QQwjshPKUp7KMB50ykEuQQ3T89PLNzrPHStbZpS13hpXeLxoW2ND1sbdngWvsP63FE_S4cVp2uXRewsVWFjfambFytD9Feoatgjzb3CL1eX71MbpPp483d5HKaGJ6lbQIyZ7Oc0EKQjMhMUtCGzFkOvJhDYY2xlgAYaTTTwPtpSmgOumAFA6ApH6GLte6ym8X4JvqOrtTSl9Hnl3K6VP9fmvJNLdynypgUWdYLnG4EvFt1NrSqLkOfRTc2xlJMgBTxsJ6arKnGuxC8Lf7WUKL6AtSmAPVTQOSfbHv7Y__-OP8GcZmD2Q</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Decker, J-M</creator><creator>Filho, O-V</creator><creator>Freitas, M-O</creator><creator>Silva-Fernandes, I-J</creator><creator>Dantas, T-S</creator><creator>Campêlo, C-S</creator><creator>Cunha, M-D</creator><creator>Silva, P-G</creator><creator>Sousa, F-B</creator><general>Medicina Oral S.L</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210701</creationdate><title>PMS2: a potential prognostic protein marker in oral squamous cell carcinoma</title><author>Decker, J-M ; Filho, O-V ; Freitas, M-O ; Silva-Fernandes, I-J ; Dantas, T-S ; Campêlo, C-S ; Cunha, M-D ; Silva, P-G ; Sousa, F-B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-6592b901f408058516ac0d2963fd6feccee066c5ca2a6363fd70196af2f266173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers, Tumor</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Middle Aged</topic><topic>Mismatch Repair Endonuclease PMS2</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Prognosis</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Decker, J-M</creatorcontrib><creatorcontrib>Filho, O-V</creatorcontrib><creatorcontrib>Freitas, M-O</creatorcontrib><creatorcontrib>Silva-Fernandes, I-J</creatorcontrib><creatorcontrib>Dantas, T-S</creatorcontrib><creatorcontrib>Campêlo, C-S</creatorcontrib><creatorcontrib>Cunha, M-D</creatorcontrib><creatorcontrib>Silva, P-G</creatorcontrib><creatorcontrib>Sousa, F-B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Decker, J-M</au><au>Filho, O-V</au><au>Freitas, M-O</au><au>Silva-Fernandes, I-J</au><au>Dantas, T-S</au><au>Campêlo, C-S</au><au>Cunha, M-D</au><au>Silva, P-G</au><au>Sousa, F-B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PMS2: a potential prognostic protein marker in oral squamous cell carcinoma</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>26</volume><issue>4</issue><spage>e451</spage><epage>e458</epage><pages>e451-e458</pages><issn>1698-6946</issn><issn>1698-4447</issn><eissn>1698-6946</eissn><abstract>An increase in oral squamous cell carcinoma (OSCC) cases was observed despite the reduction in exposure to classic risk factors. Although the exact cause of this trend remains unknown, epigenetic factors could be contributing to an increased occurrence of these tumors. This study aims to assess the influence of PMS2 protein immunoexpression on the prognosis of patients with OSCC.
This study comprised 76 cases of OSCC treated between 2011 and 2016. Immunohistochemical staining for PMS2 was performed. For evaluation, 10 fields per histological section were photographed at a 400x magnification and positively-stained cells were counted with Image J. Mann-Whitney and Kruskal-Wallis tests were used to compare the immunolabeling pattern with the clinical-pathological and prognostic characteristics. Survival analysis was performed with Chi-square, Long-Rank Mantel-Cox and Cox regression tests (p<0.05).
An overexpression of PMS2 was observed in N0/1 tumors and in oral cancers found in unusual locations. In patients ≤60 years of age, high levels of PMS2 (>60%; p=0.041) were associated with low survival (p=0.029). In multivariate analysis, surgery combined with chemotherapy (p=0.030) and high PMS2 immunoexpression (p=0.042) significantly increased the risk of death for ≤60 years old patients.
The findings of this study indicate that PMS2 can be a potential prognostic protein marker in OSCC patients 60 years of age and younger.</abstract><cop>Spain</cop><pub>Medicina Oral S.L</pub><pmid>33247565</pmid><doi>10.4317/medoral.24303</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Biomarkers, Tumor Carcinoma, Squamous Cell - diagnosis Head and Neck Neoplasms Humans Immunohistochemistry Middle Aged Mismatch Repair Endonuclease PMS2 Mouth Neoplasms - diagnosis Prognosis Squamous Cell Carcinoma of Head and Neck |
| title | PMS2: a potential prognostic protein marker in oral squamous cell carcinoma |
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