Methylation of NRN1 is a novel synthetic lethal marker of PI3K‐Akt‐mTOR and ATR inhibitors in esophageal cancer

Wnt, PI3K‐Akt‐mTOR, and NF‐κB pathways were reported to be involved in DNA damage repair (DDR). DDR‐deficient cancers become critically dependent on backup DNA repair pathways. Neuritin 1 (NRN1) is reported to be involved in PI3K‐Akt‐mTOR, and its role in DDR remains unclear. Methylation‐specific PC...

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Veröffentlicht in:	Cancer science 2021-07, Vol.112 (7), p.2870-2883
Hauptverfasser:	Du, Wushuang, Gao, Aiai, Herman, James G., Wang, Lidong, Zhang, Lirong, Jiao, Shunchang, Guo, Mingzhou
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adult Age Factors Aged Aged, 80 and over AKT protein Alcohol Drinking Animal models Animals Apoptosis Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors Ataxia Telangiectasia Mutated Proteins - metabolism ATR inhibitor Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer therapies Cell cycle Cell Line, Tumor Cell migration Cell Movement Cell proliferation Cell Proliferation - genetics CHK1 protein Cytotoxicity Deoxyribonucleic acid DNA DNA Damage DNA damage repair DNA methylation DNA Repair Epigenetics Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - mortality Esophageal Squamous Cell Carcinoma - pathology Esophagus Female Flow cytometry Genomes GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Heterografts Humans Male Methylation Mice Mice, Nude Middle Aged Neoplasm Invasiveness Neoplasm Transplantation Neuropeptides - genetics Neuropeptides - metabolism NRN1 Original Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors - therapeutic use PI3K signaling Prognosis Promoter Regions, Genetic Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Pyrazines - therapeutic use Pyrazoles - therapeutic use Signal transduction siRNA TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tumor Burden Tumor cell lines Tumors Wnt protein Xenografts
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