Role of tumor‐associated macrophages at the invasive front in human colorectal cancer progression

Macrophages are an essential component of antitumor activity; however, the role of tumor‐associated macrophages (TAMs) in colorectal cancer (CRC) remains controversial. Here, we elucidated the role of TAMs in CRC progression, especially at the early stage. We assessed the TAM number, phenotype, and...

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Veröffentlicht in:	Cancer science 2021-07, Vol.112 (7), p.2692-2704
Hauptverfasser:	Inagaki, Katsuaki, Kunisho, Shoma, Takigawa, Hidehiko, Yuge, Ryo, Oka, Shiro, Tanaka, Shinji, Shimamoto, Fumio, Chayama, Kazuaki, Kitadai, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibodies Antigens Antitumor activity Cancer CD163 antigen Colorectal cancer Colorectal carcinoma colorectal neoplasms Development and progression epithelial‐mesenchymal transition Genotype & phenotype Heat Hospitals Immunofluorescence Invasiveness Lymph nodes lymphatic metastasis polarization Lymphatic system Macrophages Metastases Metastasis neoplasm metastasis Original Pathology Patients Phenotypes Software Tumors tumor‐associated macrophages
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