Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer

Background The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic factors in these populations. Methods African Americ...

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Veröffentlicht in:	The Prostate 2021-05, Vol.81 (7), p.433-439
Hauptverfasser:	Ledet, Elisa M., Burgess, Earle F., Sokolova, Alexandra O., Jaeger, Ellen B., Hatton, Whitley, Moses, Marcus, Miller, Patrick, Cotogno, Patrick, Layton, Jodi, Barata, Pedro, Lewis, Brian E., Nakazawa, Mari, Zhu, Jason, Dellinger, Beth, Elrefai, Sara, Nafissi, Nellie N., Egan, Jan B., Shore, Neal, McKay, Rana R., Bryce, Alan H., Cheng, Heather H., Antonarakis, Emmanuel S., Sartor, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	African American African Americans African Americans - genetics BRCA1 protein BRCA2 Protein - genetics Breast cancer Deoxyribonucleic acid DNA DNA repair Family medical history Genetic diversity Genetic factors Genetic screening genetics Germ-Line Mutation germline Humans Male Metastases Metastasis metastatic prostate cancer Middle Aged Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Original Ovarian cancer pathogenic variants Population genetics Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology racial disparity White people Whites - genetics
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