Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer
Background The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic factors in these populations. Methods African Americ...
Gespeichert in:
| Veröffentlicht in: | The Prostate 2021-05, Vol.81 (7), p.433-439 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 439 |
|---|---|
| container_issue | 7 |
| container_start_page | 433 |
| container_title | The Prostate |
| container_volume | 81 |
| creator | Ledet, Elisa M. Burgess, Earle F. Sokolova, Alexandra O. Jaeger, Ellen B. Hatton, Whitley Moses, Marcus Miller, Patrick Cotogno, Patrick Layton, Jodi Barata, Pedro Lewis, Brian E. Nakazawa, Mari Zhu, Jason Dellinger, Beth Elrefai, Sara Nafissi, Nellie N. Egan, Jan B. Shore, Neal McKay, Rana R. Bryce, Alan H. Cheng, Heather H. Antonarakis, Emmanuel S. Sartor, Oliver |
| description | Background
The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic factors in these populations.
Methods
African American and Caucasian men with metastatic prostate cancer who had germline testing using multigene panels were used to generate comparisons. Germline genetic results, clinical parameters, and family histories between the two populations were analyzed.
Results
A total of 867 patients were included in this retrospective study, including 188 African American and 669 Caucasian patients. There was no significant difference in the likelihood of a pathogenic or likely‐pathogenic variants (PV/LPVs) between African American and Caucasian patients (p = .09). African American patients were more likely to have a variant of unknown significance than Caucasians (odds ratio [OR] = 1.95; p |
| doi_str_mv | 10.1002/pros.24123 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8252583</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2507732824</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4483-653318bbc8d8fce3386bc8e0733e98643ceea2ba8c210542a35b4e6abe2b24f93</originalsourceid><addsrcrecordid>eNp9kUtLJDEUhcMwou1jMz9gCMxmEMpJblJdqc2ANOMDBMXHOqTStzRSlfQkVYr_3vSUis7C1T0hXw4n9xDyjbMDzhj8WsWQDkByEF_IjLO6KhiT5VcyY1CxQnJRbZHtlO4ZyziDTbIlRFVDLcsZaRehX5noUvA0tPQWY985j7QfBzO44BN1nh620VmTZ4-TMH5JF2a0Jrl86tHTRzfcZTGYtH5n6TpTVkgzbjHuko3WdAn3XuYOuTn6c704Kc7Oj08Xh2eFlVKJYl4KwVXTWLVUrUUh1DxrZJUQWKu5FBbRQGOUBc5KCUaUjcS5aRAakG0tdsjvyXc1Nj0uLfohmk6voutNfNLBOP3xxrs7fRsetIISSiWywc8Xgxj-jpgG3btkseuMxzAmDSWrKgEKZEZ__IfehzH6_L1McQ5SKQmZ2p8omzeSIrZvYTjT6_r0elX6X30Z_v4-_hv62lcG-AQ8ug6fPrHSF5fnV5PpM9RLp1Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2511248842</pqid></control><display><type>article</type><title>Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ledet, Elisa M. ; Burgess, Earle F. ; Sokolova, Alexandra O. ; Jaeger, Ellen B. ; Hatton, Whitley ; Moses, Marcus ; Miller, Patrick ; Cotogno, Patrick ; Layton, Jodi ; Barata, Pedro ; Lewis, Brian E. ; Nakazawa, Mari ; Zhu, Jason ; Dellinger, Beth ; Elrefai, Sara ; Nafissi, Nellie N. ; Egan, Jan B. ; Shore, Neal ; McKay, Rana R. ; Bryce, Alan H. ; Cheng, Heather H. ; Antonarakis, Emmanuel S. ; Sartor, Oliver</creator><creatorcontrib>Ledet, Elisa M. ; Burgess, Earle F. ; Sokolova, Alexandra O. ; Jaeger, Ellen B. ; Hatton, Whitley ; Moses, Marcus ; Miller, Patrick ; Cotogno, Patrick ; Layton, Jodi ; Barata, Pedro ; Lewis, Brian E. ; Nakazawa, Mari ; Zhu, Jason ; Dellinger, Beth ; Elrefai, Sara ; Nafissi, Nellie N. ; Egan, Jan B. ; Shore, Neal ; McKay, Rana R. ; Bryce, Alan H. ; Cheng, Heather H. ; Antonarakis, Emmanuel S. ; Sartor, Oliver</creatorcontrib><description>Background
The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic factors in these populations.
Methods
African American and Caucasian men with metastatic prostate cancer who had germline testing using multigene panels were used to generate comparisons. Germline genetic results, clinical parameters, and family histories between the two populations were analyzed.
Results
A total of 867 patients were included in this retrospective study, including 188 African American and 669 Caucasian patients. There was no significant difference in the likelihood of a pathogenic or likely‐pathogenic variants (PV/LPVs) between African American and Caucasian patients (p = .09). African American patients were more likely to have a variant of unknown significance than Caucasians (odds ratio [OR] = 1.95; p < .0001). BRCA1 PV/LPVs were higher in African Americans (OR = 4.86; p = .04). African American patients were less likely to have a PV/LPV in non‐BRCA DNA repair genes (OR = 0.30; p = .008). Family history of breast (OR = 2.09; p = .002) or ovarian cancer (OR = 2.33; p = .04) predicted PV/LPVs in Caucasians but not African‐Americans. This underscores the limitations of family history in AA men and the importance of personal history to guide germline testing in AA men.
Conclusions
In metastatic prostate cancer patients, PV/LPVs of tested genes did not vary by race, BRCA1 PV/LPVs were more common in the African American subset. However, PV/LPVs in non‐BRCA DNA repair genes were less likely to be encountered in African Americans. Family history associated with genetic testing results in Caucasians only.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.24123</identifier><identifier>PMID: 33792945</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>African American ; African Americans ; African Americans - genetics ; BRCA1 protein ; BRCA2 Protein - genetics ; Breast cancer ; Deoxyribonucleic acid ; DNA ; DNA repair ; Family medical history ; Genetic diversity ; Genetic factors ; Genetic screening ; genetics ; Germ-Line Mutation ; germline ; Humans ; Male ; Metastases ; Metastasis ; metastatic prostate cancer ; Middle Aged ; Neoplasm Metastasis - genetics ; Neoplasm Metastasis - pathology ; Original ; Ovarian cancer ; pathogenic variants ; Population genetics ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; racial disparity ; White people ; Whites - genetics</subject><ispartof>The Prostate, 2021-05, Vol.81 (7), p.433-439</ispartof><rights>2021 The Authors. Published by Wiley Periodicals LLC</rights><rights>2021 The Authors. The Prostate Published by Wiley Periodicals LLC.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4483-653318bbc8d8fce3386bc8e0733e98643ceea2ba8c210542a35b4e6abe2b24f93</citedby><cites>FETCH-LOGICAL-c4483-653318bbc8d8fce3386bc8e0733e98643ceea2ba8c210542a35b4e6abe2b24f93</cites><orcidid>0000-0003-0436-5931 ; 0000-0002-1365-0702 ; 0000-0002-8777-7343 ; 0000-0002-0206-3895 ; 0000-0003-0031-9655 ; 0000-0003-1230-3255</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.24123$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.24123$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33792945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ledet, Elisa M.</creatorcontrib><creatorcontrib>Burgess, Earle F.</creatorcontrib><creatorcontrib>Sokolova, Alexandra O.</creatorcontrib><creatorcontrib>Jaeger, Ellen B.</creatorcontrib><creatorcontrib>Hatton, Whitley</creatorcontrib><creatorcontrib>Moses, Marcus</creatorcontrib><creatorcontrib>Miller, Patrick</creatorcontrib><creatorcontrib>Cotogno, Patrick</creatorcontrib><creatorcontrib>Layton, Jodi</creatorcontrib><creatorcontrib>Barata, Pedro</creatorcontrib><creatorcontrib>Lewis, Brian E.</creatorcontrib><creatorcontrib>Nakazawa, Mari</creatorcontrib><creatorcontrib>Zhu, Jason</creatorcontrib><creatorcontrib>Dellinger, Beth</creatorcontrib><creatorcontrib>Elrefai, Sara</creatorcontrib><creatorcontrib>Nafissi, Nellie N.</creatorcontrib><creatorcontrib>Egan, Jan B.</creatorcontrib><creatorcontrib>Shore, Neal</creatorcontrib><creatorcontrib>McKay, Rana R.</creatorcontrib><creatorcontrib>Bryce, Alan H.</creatorcontrib><creatorcontrib>Cheng, Heather H.</creatorcontrib><creatorcontrib>Antonarakis, Emmanuel S.</creatorcontrib><creatorcontrib>Sartor, Oliver</creatorcontrib><title>Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>Background
The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic factors in these populations.
Methods
African American and Caucasian men with metastatic prostate cancer who had germline testing using multigene panels were used to generate comparisons. Germline genetic results, clinical parameters, and family histories between the two populations were analyzed.
Results
A total of 867 patients were included in this retrospective study, including 188 African American and 669 Caucasian patients. There was no significant difference in the likelihood of a pathogenic or likely‐pathogenic variants (PV/LPVs) between African American and Caucasian patients (p = .09). African American patients were more likely to have a variant of unknown significance than Caucasians (odds ratio [OR] = 1.95; p < .0001). BRCA1 PV/LPVs were higher in African Americans (OR = 4.86; p = .04). African American patients were less likely to have a PV/LPV in non‐BRCA DNA repair genes (OR = 0.30; p = .008). Family history of breast (OR = 2.09; p = .002) or ovarian cancer (OR = 2.33; p = .04) predicted PV/LPVs in Caucasians but not African‐Americans. This underscores the limitations of family history in AA men and the importance of personal history to guide germline testing in AA men.
Conclusions
In metastatic prostate cancer patients, PV/LPVs of tested genes did not vary by race, BRCA1 PV/LPVs were more common in the African American subset. However, PV/LPVs in non‐BRCA DNA repair genes were less likely to be encountered in African Americans. Family history associated with genetic testing results in Caucasians only.</description><subject>African American</subject><subject>African Americans</subject><subject>African Americans - genetics</subject><subject>BRCA1 protein</subject><subject>BRCA2 Protein - genetics</subject><subject>Breast cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA repair</subject><subject>Family medical history</subject><subject>Genetic diversity</subject><subject>Genetic factors</subject><subject>Genetic screening</subject><subject>genetics</subject><subject>Germ-Line Mutation</subject><subject>germline</subject><subject>Humans</subject><subject>Male</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>metastatic prostate cancer</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis - genetics</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Original</subject><subject>Ovarian cancer</subject><subject>pathogenic variants</subject><subject>Population genetics</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>racial disparity</subject><subject>White people</subject><subject>Whites - genetics</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUtLJDEUhcMwou1jMz9gCMxmEMpJblJdqc2ANOMDBMXHOqTStzRSlfQkVYr_3vSUis7C1T0hXw4n9xDyjbMDzhj8WsWQDkByEF_IjLO6KhiT5VcyY1CxQnJRbZHtlO4ZyziDTbIlRFVDLcsZaRehX5noUvA0tPQWY985j7QfBzO44BN1nh620VmTZ4-TMH5JF2a0Jrl86tHTRzfcZTGYtH5n6TpTVkgzbjHuko3WdAn3XuYOuTn6c704Kc7Oj08Xh2eFlVKJYl4KwVXTWLVUrUUh1DxrZJUQWKu5FBbRQGOUBc5KCUaUjcS5aRAakG0tdsjvyXc1Nj0uLfohmk6voutNfNLBOP3xxrs7fRsetIISSiWywc8Xgxj-jpgG3btkseuMxzAmDSWrKgEKZEZ__IfehzH6_L1McQ5SKQmZ2p8omzeSIrZvYTjT6_r0elX6X30Z_v4-_hv62lcG-AQ8ug6fPrHSF5fnV5PpM9RLp1Y</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Ledet, Elisa M.</creator><creator>Burgess, Earle F.</creator><creator>Sokolova, Alexandra O.</creator><creator>Jaeger, Ellen B.</creator><creator>Hatton, Whitley</creator><creator>Moses, Marcus</creator><creator>Miller, Patrick</creator><creator>Cotogno, Patrick</creator><creator>Layton, Jodi</creator><creator>Barata, Pedro</creator><creator>Lewis, Brian E.</creator><creator>Nakazawa, Mari</creator><creator>Zhu, Jason</creator><creator>Dellinger, Beth</creator><creator>Elrefai, Sara</creator><creator>Nafissi, Nellie N.</creator><creator>Egan, Jan B.</creator><creator>Shore, Neal</creator><creator>McKay, Rana R.</creator><creator>Bryce, Alan H.</creator><creator>Cheng, Heather H.</creator><creator>Antonarakis, Emmanuel S.</creator><creator>Sartor, Oliver</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0436-5931</orcidid><orcidid>https://orcid.org/0000-0002-1365-0702</orcidid><orcidid>https://orcid.org/0000-0002-8777-7343</orcidid><orcidid>https://orcid.org/0000-0002-0206-3895</orcidid><orcidid>https://orcid.org/0000-0003-0031-9655</orcidid><orcidid>https://orcid.org/0000-0003-1230-3255</orcidid></search><sort><creationdate>20210501</creationdate><title>Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer</title><author>Ledet, Elisa M. ; Burgess, Earle F. ; Sokolova, Alexandra O. ; Jaeger, Ellen B. ; Hatton, Whitley ; Moses, Marcus ; Miller, Patrick ; Cotogno, Patrick ; Layton, Jodi ; Barata, Pedro ; Lewis, Brian E. ; Nakazawa, Mari ; Zhu, Jason ; Dellinger, Beth ; Elrefai, Sara ; Nafissi, Nellie N. ; Egan, Jan B. ; Shore, Neal ; McKay, Rana R. ; Bryce, Alan H. ; Cheng, Heather H. ; Antonarakis, Emmanuel S. ; Sartor, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4483-653318bbc8d8fce3386bc8e0733e98643ceea2ba8c210542a35b4e6abe2b24f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>African American</topic><topic>African Americans</topic><topic>African Americans - genetics</topic><topic>BRCA1 protein</topic><topic>BRCA2 Protein - genetics</topic><topic>Breast cancer</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA repair</topic><topic>Family medical history</topic><topic>Genetic diversity</topic><topic>Genetic factors</topic><topic>Genetic screening</topic><topic>genetics</topic><topic>Germ-Line Mutation</topic><topic>germline</topic><topic>Humans</topic><topic>Male</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>metastatic prostate cancer</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis - genetics</topic><topic>Neoplasm Metastasis - pathology</topic><topic>Original</topic><topic>Ovarian cancer</topic><topic>pathogenic variants</topic><topic>Population genetics</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - pathology</topic><topic>racial disparity</topic><topic>White people</topic><topic>Whites - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ledet, Elisa M.</creatorcontrib><creatorcontrib>Burgess, Earle F.</creatorcontrib><creatorcontrib>Sokolova, Alexandra O.</creatorcontrib><creatorcontrib>Jaeger, Ellen B.</creatorcontrib><creatorcontrib>Hatton, Whitley</creatorcontrib><creatorcontrib>Moses, Marcus</creatorcontrib><creatorcontrib>Miller, Patrick</creatorcontrib><creatorcontrib>Cotogno, Patrick</creatorcontrib><creatorcontrib>Layton, Jodi</creatorcontrib><creatorcontrib>Barata, Pedro</creatorcontrib><creatorcontrib>Lewis, Brian E.</creatorcontrib><creatorcontrib>Nakazawa, Mari</creatorcontrib><creatorcontrib>Zhu, Jason</creatorcontrib><creatorcontrib>Dellinger, Beth</creatorcontrib><creatorcontrib>Elrefai, Sara</creatorcontrib><creatorcontrib>Nafissi, Nellie N.</creatorcontrib><creatorcontrib>Egan, Jan B.</creatorcontrib><creatorcontrib>Shore, Neal</creatorcontrib><creatorcontrib>McKay, Rana R.</creatorcontrib><creatorcontrib>Bryce, Alan H.</creatorcontrib><creatorcontrib>Cheng, Heather H.</creatorcontrib><creatorcontrib>Antonarakis, Emmanuel S.</creatorcontrib><creatorcontrib>Sartor, Oliver</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ledet, Elisa M.</au><au>Burgess, Earle F.</au><au>Sokolova, Alexandra O.</au><au>Jaeger, Ellen B.</au><au>Hatton, Whitley</au><au>Moses, Marcus</au><au>Miller, Patrick</au><au>Cotogno, Patrick</au><au>Layton, Jodi</au><au>Barata, Pedro</au><au>Lewis, Brian E.</au><au>Nakazawa, Mari</au><au>Zhu, Jason</au><au>Dellinger, Beth</au><au>Elrefai, Sara</au><au>Nafissi, Nellie N.</au><au>Egan, Jan B.</au><au>Shore, Neal</au><au>McKay, Rana R.</au><au>Bryce, Alan H.</au><au>Cheng, Heather H.</au><au>Antonarakis, Emmanuel S.</au><au>Sartor, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>81</volume><issue>7</issue><spage>433</spage><epage>439</epage><pages>433-439</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><abstract>Background
The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic factors in these populations.
Methods
African American and Caucasian men with metastatic prostate cancer who had germline testing using multigene panels were used to generate comparisons. Germline genetic results, clinical parameters, and family histories between the two populations were analyzed.
Results
A total of 867 patients were included in this retrospective study, including 188 African American and 669 Caucasian patients. There was no significant difference in the likelihood of a pathogenic or likely‐pathogenic variants (PV/LPVs) between African American and Caucasian patients (p = .09). African American patients were more likely to have a variant of unknown significance than Caucasians (odds ratio [OR] = 1.95; p < .0001). BRCA1 PV/LPVs were higher in African Americans (OR = 4.86; p = .04). African American patients were less likely to have a PV/LPV in non‐BRCA DNA repair genes (OR = 0.30; p = .008). Family history of breast (OR = 2.09; p = .002) or ovarian cancer (OR = 2.33; p = .04) predicted PV/LPVs in Caucasians but not African‐Americans. This underscores the limitations of family history in AA men and the importance of personal history to guide germline testing in AA men.
Conclusions
In metastatic prostate cancer patients, PV/LPVs of tested genes did not vary by race, BRCA1 PV/LPVs were more common in the African American subset. However, PV/LPVs in non‐BRCA DNA repair genes were less likely to be encountered in African Americans. Family history associated with genetic testing results in Caucasians only.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33792945</pmid><doi>10.1002/pros.24123</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0436-5931</orcidid><orcidid>https://orcid.org/0000-0002-1365-0702</orcidid><orcidid>https://orcid.org/0000-0002-8777-7343</orcidid><orcidid>https://orcid.org/0000-0002-0206-3895</orcidid><orcidid>https://orcid.org/0000-0003-0031-9655</orcidid><orcidid>https://orcid.org/0000-0003-1230-3255</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0270-4137 |
| ispartof | The Prostate, 2021-05, Vol.81 (7), p.433-439 |
| issn | 0270-4137 1097-0045 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8252583 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | African American African Americans African Americans - genetics BRCA1 protein BRCA2 Protein - genetics Breast cancer Deoxyribonucleic acid DNA DNA repair Family medical history Genetic diversity Genetic factors Genetic screening genetics Germ-Line Mutation germline Humans Male Metastases Metastasis metastatic prostate cancer Middle Aged Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Original Ovarian cancer pathogenic variants Population genetics Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology racial disparity White people Whites - genetics |
| title | Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T00%3A28%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20germline%20mutations%20in%20African%20American%20and%20Caucasian%20men%20with%20metastatic%20prostate%20cancer&rft.jtitle=The%20Prostate&rft.au=Ledet,%20Elisa%20M.&rft.date=2021-05-01&rft.volume=81&rft.issue=7&rft.spage=433&rft.epage=439&rft.pages=433-439&rft.issn=0270-4137&rft.eissn=1097-0045&rft_id=info:doi/10.1002/pros.24123&rft_dat=%3Cproquest_pubme%3E2507732824%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2511248842&rft_id=info:pmid/33792945&rfr_iscdi=true |