Cell‐Based Identification of New IDO1 Modulator Chemotypes

The immunoregulatory enzyme indoleamine‐2,3‐dioxygenase (IDO1) strengthens cancer immune escape, and inhibition of IDO1 by means of new chemotypes and mechanisms of action is considered a promising opportunity for IDO1 inhibitor discovery. IDO1 is a cofactor‐binding, redox‐sensitive protein, which c...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-04, Vol.60 (18), p.9869-9874
Hauptverfasser:	Hennes, Elisabeth, Lampe, Philipp, Dötsch, Lara, Bruning, Nora, Pulvermacher, Lisa‐Marie, Sievers, Sonja, Ziegler, Slava, Waldmann, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Cancer immunotherapy Communication Communications Dioxygenase Fluorescence Heme heme proteins high throughput screening immunology Immunomodulation Immunoregulation Inhibitors Modulators Regulators
Online-Zugang:	Volltext
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