Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire
Aims We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ‐5D), and to compare their prognostic value in men and women with heart failure and reduced eje...
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| Veröffentlicht in: | European journal of heart failure 2021-04, Vol.23 (4), p.567-577 |
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| creator | Ravera, Alice Santema, Bernadet T. Sama, Iziah E. Meyer, Sven Lombardi, Carlo M. Carubelli, Valentina Ferreira, João Pedro Lang, Chim C. Dickstein, Kenneth Anker, Stefan D. Samani, Nilesh J. Zannad, Faiez van Veldhuisen, Dirk J. Teerlink, John R. Metra, Marco Voors, Adriaan A. |
| description | Aims
We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ‐5D), and to compare their prognostic value in men and women with heart failure and reduced ejection fraction (HFrEF).
Methods and results
From the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) we compared KCCQ and EQ‐5D at baseline and after 9 months in 1276 men and 373 women with new‐onset or worsening symptoms of HFrEF, who were sub‐optimally treated and in whom there was an anticipated up‐titration of guideline‐derived medical therapies. Women had significantly worse baseline QoL (median) as compared with men, both when assessed with KCCQ overall score (KCCQ‐OS, 44 vs. 53, P |
| doi_str_mv | 10.1002/ejhf.2154 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8252457</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2502203405</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4494-fa2077f99e37217b83f336636fe3b1713f53857e9f6ef1bc301b355c546151b53</originalsourceid><addsrcrecordid>eNp1kt-K1DAUh4so7rp64QtILhXsbv42rRfCMsw66oAM6HVIOyc2S9uMSbpDH853M50Z11XwKoec73zJgV-WvST4kmBMr-C2NZeUCP4oOyelrHJccv441aws86rk9Cx7FsItxkQm_Gl2xpikpSzoefZzM-rOxgk5gzprANkB9TAgPWzR3s3V3sYWtaB9REbbbvTwDukQXGN1tO7Ud2NsEv32MJeqnfY2pGYNcQ9JEltAn_UQdECL-bWF9lvr-sntdGwntBkhzLJBWw8HxzywHL3buA4JtLXpJyEBAf14iD7PnhjdBXhxOi-ybzfLr4tVvv7y4ePiep03nFc8N5piKU1VQdqbyLpkhrGiYIUBVhNJmBGsFBIqU4AhdcMwqZkQjeAFEaQW7CJ7f_TuxrqHbQND9LpTO2977SfltFV_dwbbqu_uTpVUUC5kErw5Ctp_xlbXazXfYSYF44TfkcS-Pj3m3WFb1dvQQNfpAdwYFBWYUsw4Fn-0jXcheDD3boLVHA01R0PN0Ujsq4c73JO_s5CAqyOwtx1M_zep5afVzUH5C1vox04</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2502203405</pqid></control><display><type>article</type><title>Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><creator>Ravera, Alice ; Santema, Bernadet T. ; Sama, Iziah E. ; Meyer, Sven ; Lombardi, Carlo M. ; Carubelli, Valentina ; Ferreira, João Pedro ; Lang, Chim C. ; Dickstein, Kenneth ; Anker, Stefan D. ; Samani, Nilesh J. ; Zannad, Faiez ; van Veldhuisen, Dirk J. ; Teerlink, John R. ; Metra, Marco ; Voors, Adriaan A.</creator><creatorcontrib>Ravera, Alice ; Santema, Bernadet T. ; Sama, Iziah E. ; Meyer, Sven ; Lombardi, Carlo M. ; Carubelli, Valentina ; Ferreira, João Pedro ; Lang, Chim C. ; Dickstein, Kenneth ; Anker, Stefan D. ; Samani, Nilesh J. ; Zannad, Faiez ; van Veldhuisen, Dirk J. ; Teerlink, John R. ; Metra, Marco ; Voors, Adriaan A.</creatorcontrib><description>Aims
We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ‐5D), and to compare their prognostic value in men and women with heart failure and reduced ejection fraction (HFrEF).
Methods and results
From the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) we compared KCCQ and EQ‐5D at baseline and after 9 months in 1276 men and 373 women with new‐onset or worsening symptoms of HFrEF, who were sub‐optimally treated and in whom there was an anticipated up‐titration of guideline‐derived medical therapies. Women had significantly worse baseline QoL (median) as compared with men, both when assessed with KCCQ overall score (KCCQ‐OS, 44 vs. 53, P < 0.001) and EQ‐5D utility score (0.62 vs. 0.73, P < 0.001). QoL improved equally in women and men at follow‐up. All summary measures of QoL were independently associated with all‐cause mortality, with KCCQ‐OS showing the most remarkable association with mortality up to 1 year compared to the EQ‐5D scores (C‐statistic 0.650 for KCCQ‐OS vs. 0.633 and 0.599 for EQ‐5D utility score and EQ‐5D visual analogue scale, respectively). QoL was associated with all outcomes analysed, both in men and women (all P for interaction with sex >0.2).
Conclusion
Amongst patients with HFrEF, women reported significantly worse QoL than men. QoL was independently associated with subsequent outcome, similarly in men and women. The KCCQ in general, and the KCCQ‐OS in particular, showed the strongest independent association with outcome.
Sex differences in quality of life, in its relationship with outcomes, and predictive ability of different quality of life measures towards outcome. BIOSTAT‐CHF, BIOlogy Study to TAilored Treatment in Chronic Heart Failure; EQ‐5D, EuroQoL 5 dimensions; KCCQ, Kansas City Cardiomyopathy Questionnaire; OS, overall score; US, utility score; VAS, visual analogue scale.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1002/ejhf.2154</identifier><identifier>PMID: 33728762</identifier><language>eng</language><publisher>Oxford, UK: John Wiley & Sons, Ltd</publisher><subject>Cardiology and cardiovascular system ; Heart failure ; Human health and pathology ; Life Sciences ; Outcome ; Quality of Life ; Sex ; Women</subject><ispartof>European journal of heart failure, 2021-04, Vol.23 (4), p.567-577</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.</rights><rights>2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4494-fa2077f99e37217b83f336636fe3b1713f53857e9f6ef1bc301b355c546151b53</citedby><cites>FETCH-LOGICAL-c4494-fa2077f99e37217b83f336636fe3b1713f53857e9f6ef1bc301b355c546151b53</cites><orcidid>0000-0001-6691-8568</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejhf.2154$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejhf.2154$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33728762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lorraine.fr/hal-03753414$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ravera, Alice</creatorcontrib><creatorcontrib>Santema, Bernadet T.</creatorcontrib><creatorcontrib>Sama, Iziah E.</creatorcontrib><creatorcontrib>Meyer, Sven</creatorcontrib><creatorcontrib>Lombardi, Carlo M.</creatorcontrib><creatorcontrib>Carubelli, Valentina</creatorcontrib><creatorcontrib>Ferreira, João Pedro</creatorcontrib><creatorcontrib>Lang, Chim C.</creatorcontrib><creatorcontrib>Dickstein, Kenneth</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Zannad, Faiez</creatorcontrib><creatorcontrib>van Veldhuisen, Dirk J.</creatorcontrib><creatorcontrib>Teerlink, John R.</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>Voors, Adriaan A.</creatorcontrib><title>Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire</title><title>European journal of heart failure</title><addtitle>Eur J Heart Fail</addtitle><description>Aims
We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ‐5D), and to compare their prognostic value in men and women with heart failure and reduced ejection fraction (HFrEF).
Methods and results
From the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) we compared KCCQ and EQ‐5D at baseline and after 9 months in 1276 men and 373 women with new‐onset or worsening symptoms of HFrEF, who were sub‐optimally treated and in whom there was an anticipated up‐titration of guideline‐derived medical therapies. Women had significantly worse baseline QoL (median) as compared with men, both when assessed with KCCQ overall score (KCCQ‐OS, 44 vs. 53, P < 0.001) and EQ‐5D utility score (0.62 vs. 0.73, P < 0.001). QoL improved equally in women and men at follow‐up. All summary measures of QoL were independently associated with all‐cause mortality, with KCCQ‐OS showing the most remarkable association with mortality up to 1 year compared to the EQ‐5D scores (C‐statistic 0.650 for KCCQ‐OS vs. 0.633 and 0.599 for EQ‐5D utility score and EQ‐5D visual analogue scale, respectively). QoL was associated with all outcomes analysed, both in men and women (all P for interaction with sex >0.2).
Conclusion
Amongst patients with HFrEF, women reported significantly worse QoL than men. QoL was independently associated with subsequent outcome, similarly in men and women. The KCCQ in general, and the KCCQ‐OS in particular, showed the strongest independent association with outcome.
Sex differences in quality of life, in its relationship with outcomes, and predictive ability of different quality of life measures towards outcome. BIOSTAT‐CHF, BIOlogy Study to TAilored Treatment in Chronic Heart Failure; EQ‐5D, EuroQoL 5 dimensions; KCCQ, Kansas City Cardiomyopathy Questionnaire; OS, overall score; US, utility score; VAS, visual analogue scale.</description><subject>Cardiology and cardiovascular system</subject><subject>Heart failure</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><subject>Outcome</subject><subject>Quality of Life</subject><subject>Sex</subject><subject>Women</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kt-K1DAUh4so7rp64QtILhXsbv42rRfCMsw66oAM6HVIOyc2S9uMSbpDH853M50Z11XwKoec73zJgV-WvST4kmBMr-C2NZeUCP4oOyelrHJccv441aws86rk9Cx7FsItxkQm_Gl2xpikpSzoefZzM-rOxgk5gzprANkB9TAgPWzR3s3V3sYWtaB9REbbbvTwDukQXGN1tO7Ud2NsEv32MJeqnfY2pGYNcQ9JEltAn_UQdECL-bWF9lvr-sntdGwntBkhzLJBWw8HxzywHL3buA4JtLXpJyEBAf14iD7PnhjdBXhxOi-ybzfLr4tVvv7y4ePiep03nFc8N5piKU1VQdqbyLpkhrGiYIUBVhNJmBGsFBIqU4AhdcMwqZkQjeAFEaQW7CJ7f_TuxrqHbQND9LpTO2977SfltFV_dwbbqu_uTpVUUC5kErw5Ctp_xlbXazXfYSYF44TfkcS-Pj3m3WFb1dvQQNfpAdwYFBWYUsw4Fn-0jXcheDD3boLVHA01R0PN0Ujsq4c73JO_s5CAqyOwtx1M_zep5afVzUH5C1vox04</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Ravera, Alice</creator><creator>Santema, Bernadet T.</creator><creator>Sama, Iziah E.</creator><creator>Meyer, Sven</creator><creator>Lombardi, Carlo M.</creator><creator>Carubelli, Valentina</creator><creator>Ferreira, João Pedro</creator><creator>Lang, Chim C.</creator><creator>Dickstein, Kenneth</creator><creator>Anker, Stefan D.</creator><creator>Samani, Nilesh J.</creator><creator>Zannad, Faiez</creator><creator>van Veldhuisen, Dirk J.</creator><creator>Teerlink, John R.</creator><creator>Metra, Marco</creator><creator>Voors, Adriaan A.</creator><general>John Wiley & Sons, Ltd</general><general>European Society of Cardiology (Wiley)</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6691-8568</orcidid></search><sort><creationdate>202104</creationdate><title>Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire</title><author>Ravera, Alice ; Santema, Bernadet T. ; Sama, Iziah E. ; Meyer, Sven ; Lombardi, Carlo M. ; Carubelli, Valentina ; Ferreira, João Pedro ; Lang, Chim C. ; Dickstein, Kenneth ; Anker, Stefan D. ; Samani, Nilesh J. ; Zannad, Faiez ; van Veldhuisen, Dirk J. ; Teerlink, John R. ; Metra, Marco ; Voors, Adriaan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4494-fa2077f99e37217b83f336636fe3b1713f53857e9f6ef1bc301b355c546151b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiology and cardiovascular system</topic><topic>Heart failure</topic><topic>Human health and pathology</topic><topic>Life Sciences</topic><topic>Outcome</topic><topic>Quality of Life</topic><topic>Sex</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ravera, Alice</creatorcontrib><creatorcontrib>Santema, Bernadet T.</creatorcontrib><creatorcontrib>Sama, Iziah E.</creatorcontrib><creatorcontrib>Meyer, Sven</creatorcontrib><creatorcontrib>Lombardi, Carlo M.</creatorcontrib><creatorcontrib>Carubelli, Valentina</creatorcontrib><creatorcontrib>Ferreira, João Pedro</creatorcontrib><creatorcontrib>Lang, Chim C.</creatorcontrib><creatorcontrib>Dickstein, Kenneth</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Zannad, Faiez</creatorcontrib><creatorcontrib>van Veldhuisen, Dirk J.</creatorcontrib><creatorcontrib>Teerlink, John R.</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>Voors, Adriaan A.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ravera, Alice</au><au>Santema, Bernadet T.</au><au>Sama, Iziah E.</au><au>Meyer, Sven</au><au>Lombardi, Carlo M.</au><au>Carubelli, Valentina</au><au>Ferreira, João Pedro</au><au>Lang, Chim C.</au><au>Dickstein, Kenneth</au><au>Anker, Stefan D.</au><au>Samani, Nilesh J.</au><au>Zannad, Faiez</au><au>van Veldhuisen, Dirk J.</au><au>Teerlink, John R.</au><au>Metra, Marco</au><au>Voors, Adriaan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire</atitle><jtitle>European journal of heart failure</jtitle><addtitle>Eur J Heart Fail</addtitle><date>2021-04</date><risdate>2021</risdate><volume>23</volume><issue>4</issue><spage>567</spage><epage>577</epage><pages>567-577</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Aims
We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ‐5D), and to compare their prognostic value in men and women with heart failure and reduced ejection fraction (HFrEF).
Methods and results
From the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) we compared KCCQ and EQ‐5D at baseline and after 9 months in 1276 men and 373 women with new‐onset or worsening symptoms of HFrEF, who were sub‐optimally treated and in whom there was an anticipated up‐titration of guideline‐derived medical therapies. Women had significantly worse baseline QoL (median) as compared with men, both when assessed with KCCQ overall score (KCCQ‐OS, 44 vs. 53, P < 0.001) and EQ‐5D utility score (0.62 vs. 0.73, P < 0.001). QoL improved equally in women and men at follow‐up. All summary measures of QoL were independently associated with all‐cause mortality, with KCCQ‐OS showing the most remarkable association with mortality up to 1 year compared to the EQ‐5D scores (C‐statistic 0.650 for KCCQ‐OS vs. 0.633 and 0.599 for EQ‐5D utility score and EQ‐5D visual analogue scale, respectively). QoL was associated with all outcomes analysed, both in men and women (all P for interaction with sex >0.2).
Conclusion
Amongst patients with HFrEF, women reported significantly worse QoL than men. QoL was independently associated with subsequent outcome, similarly in men and women. The KCCQ in general, and the KCCQ‐OS in particular, showed the strongest independent association with outcome.
Sex differences in quality of life, in its relationship with outcomes, and predictive ability of different quality of life measures towards outcome. BIOSTAT‐CHF, BIOlogy Study to TAilored Treatment in Chronic Heart Failure; EQ‐5D, EuroQoL 5 dimensions; KCCQ, Kansas City Cardiomyopathy Questionnaire; OS, overall score; US, utility score; VAS, visual analogue scale.</abstract><cop>Oxford, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>33728762</pmid><doi>10.1002/ejhf.2154</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6691-8568</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of heart failure, 2021-04, Vol.23 (4), p.567-577 |
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| source | Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | Cardiology and cardiovascular system Heart failure Human health and pathology Life Sciences Outcome Quality of Life Sex Women |
| title | Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire |
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