The energy sensor AMPK orchestrates metabolic and translational adaptation in expanding T helper cells

The importance of cellular metabolic adaptation in inducing robust T cell responses is well established. However, the mechanism by which T cells link information regarding nutrient supply to clonal expansion and effector function is still enigmatic. Herein, we report that the metabolic sensor adenos...

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Veröffentlicht in:	The FASEB journal 2021-04, Vol.35 (4), p.e21217-n/a
Hauptverfasser:	Mayer, Katharina A., Smole, Ursula, Zhu, Ci, Derdak, Sophia, Minervina, Anastasia A., Salnikova, Maria, Witzeneder, Nadine, Christamentl, Anna, Boucheron, Nicole, Waidhofer‐Söllner, Petra, Trauner, Michael, Hoermann, Gregor, Schmetterer, Klaus G., Mamedov, Ilgar Z., Bilban, Martin, Ellmeier, Wilfried, Pickl, Winfried F., Gualdoni, Guido A., Zlabinger, Gerhard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPK cellular metabolism T cell translation
Online-Zugang:	Volltext
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