Hyperpolarized 13C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study

Hyperpolarized [1‐13C]fumarate is a promising magnetic resonance imaging (MRI) biomarker for cellular necrosis, which plays an important role in various disease and cancerous pathological processes. To demonstrate the feasibility of MRI of [1‐13C]fumarate metabolism using parahydrogen‐induced polari...

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Veröffentlicht in:	Chemphyschem 2021-05, Vol.22 (10), p.915-923
Hauptverfasser:	Stewart, Neil J., Nakano, Hitomi, Sugai, Shuto, Tomohiro, Mitsushi, Kase, Yuki, Uchio, Yoshiki, Yamaguchi, Toru, Matsuo, Yujirou, Naganuma, Tatsuya, Takeda, Norihiko, Nishimura, Ikuya, Hirata, Hiroshi, Hashimoto, Takuya, Matsumoto, Shingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers density functional calculations Density functional theory fumarate Hepatitis Hydrogenation hyperpolarized 13C MRS/I In vivo methods and tests Induced polarization Magnetic resonance imaging Malate matabolism Medical imaging Metabolism Necrosis parahydrogen-induced polarization Ruthenium Selectivity
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