A SARS‐CoV‐2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD‐Independent Mechanism

The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS‐CoV‐2 (CoV2‐S) binds to the human angiotensin‐converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated selection process and identified an aptamer t...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-04, Vol.60 (18), p.10279-10285
Hauptverfasser:	Schmitz, Anton, Weber, Anna, Bayin, Mehtap, Breuers, Stefan, Fieberg, Volkmar, Famulok, Michael, Mayer, Günter
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism antiviral Antiviral Agents - chemistry Antiviral Agents - pharmacology Aptamers Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - pharmacology Binding Binding Sites - drug effects Blocking coronavirus Coronaviruses COVID-19 - drug therapy COVID-19 - metabolism Deoxyribonucleic acid DNA Drug development Drug Discovery Glycoproteins Harnesses HEK293 Cells Humans Infections Protein Binding - drug effects Protein Interaction Domains and Motifs - drug effects SARS-CoV-2 SARS-CoV-2 - chemistry SARS-CoV-2 - drug effects SARS-CoV-2 - physiology SELEX SELEX Aptamer Technique Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - metabolism Viral diseases Viruses
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