Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia

Although cyclooxygenase (COX) role in cancer angiogenesis has been studied, little is known about its role in brain angioplasticity. In the present study, we chronically infused mice with ketorolac, a non‐specific COX inhibitor that does not cross the blood–brain barrier (BBB), under normoxia or 50%...

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Veröffentlicht in:	Journal of neurochemistry 2021-07, Vol.158 (2), p.246-261
Hauptverfasser:	Seeger, Drew R., Golovko, Svetlana A., Grove, Bryon D., Golovko, Mikhail Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Blood-brain barrier brain Chemokine receptors CXCR4 protein cyclooxygenase Dosage Endothelium Growth factors Hypoxia Kinases non‐steroidal anti‐inflammatory drugs Original ORIGINAL ARTICLES Prostaglandin endoperoxide synthase prostaglandins Protein kinase Receptors Vascular endothelial growth factor
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