The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers

Dickkopf1 (DKK1) is overexpressed in various cancers and promotes cancer cell proliferation by binding to cytoskeleton-associated protein 4 (CKAP4). However, the mechanisms underlying DKK1 expression are poorly understood. RNA sequence analysis revealed that expression of the transcription factor fo...

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Veröffentlicht in:	Oncogene 2021-07, Vol.40 (26), p.4486-4502
Hauptverfasser:	Kimura, Hirokazu, Sada, Ryota, Takada, Naoki, Harada, Akikazu, Doki, Yuichiro, Eguchi, Hidetoshi, Yamamoto, Hideki, Kikuchi, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 45/15 45/23 631/45 631/67/1504/1713 631/67/395 631/80/86 692/53/2422 82/80 96/109 96/63 96/95 Adenocarcinoma Adult Aged Aged, 80 and over AKT protein Apoptosis Binding sites Biological control systems Cancer Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell Biology Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cellular signal transduction Cytoskeleton Development and progression Dkk1 protein Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - pathology Esophagus Feedback Forkhead Box Protein M1 - genetics Forkhead protein Gene expression Gene Expression Regulation, Neoplastic - genetics Genetic aspects Health aspects Human Genetics Humans Intercellular Signaling Peptides and Proteins - genetics Internal Medicine Kinases Medicine Medicine & Public Health Metabolic pathways Middle Aged Multivariate analysis Nucleotide sequence Oncology Oncology, Experimental Pancreas Pancreas - pathology Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Sequence analysis Signal transduction Signal Transduction - genetics Squamous cell carcinoma Wnt protein
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