High preharvest donor Foxp3 mRNA level predicts late relapse of acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

Objectives The curative effect of allogeneic haematopoietic stem cell transplantation (HSCT) for acute leukaemia is due in part to the donor T cell–mediated graft‐versus‐leukaemia immune reaction (GvL). Several studies have suggested that donor CD25+CD4+Foxp3+regulator T cells (Tregs) may decrease g...

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Veröffentlicht in:	European journal of haematology 2021-05, Vol.106 (5), p.643-653
Hauptverfasser:	Jacobsen, Niels, Frisch, Tina, Keiding, Niels, Heilmann, Carsten, Sengeløv, Henrik, Madsen, Hans O., Marquart, Hanne, Dickmeiss, Ebbe, Andersen, Mette K., Christiansen, Claus B., Ryder, Lars P.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukaemia Acute lymphoblastic leukemia Adolescent Adult Biomarkers Bone marrow Bone marrow transplantation CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - metabolism Child Child, Preschool Female Forkhead Transcription Factors - genetics Foxp3 Foxp3 protein Graft vs Host Disease - diagnosis Graft vs Host Disease - etiology Graft vs Host Disease - therapy Graft-versus-host reaction haematopoietic stem cell transplantation Hematopoietic stem cells Humans Leukemia Lymphocytes T Male Middle Aged mRNA Multivariate Analysis Neoplasm Recurrence, Local Original Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prognosis Proportional Hazards Models Real-Time Polymerase Chain Reaction regulatory T cells RNA, Messenger - genetics Stem cell transplantation Stem cells Tissue Donors Young Adult
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