Insight into the Mechanism of Action and Peptide‐Membrane Interactions of Aib‐Rich Peptides: Multitechnique Experimental and Theoretical Analysis

The increase in resistant bacterial strains necessitates the identification of new antimicrobial molecules. Antimicrobial peptides (AMPs) are an attractive option because of evidence that bacteria cannot easily develop resistance to AMPs. The peptaibols, a class of naturally occurring AMPs, have sho...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-05, Vol.22 (9), p.1656-1667
Hauptverfasser:	Lizio, Maria Giovanna, Campana, Mario, De Poli, Matteo, Jefferies, Damien F., Cullen, William, Andrushchenko, Valery, Chmel, Nikola P., Bouř, Petr, Khalid, Syma, Clayden, Jonathan, Blanch, Ewan, Rodger, Alison, Webb, Simon J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antimicrobial agents Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - metabolism Antimicrobial peptides Circular Dichroism Dichroism Drug development Linear dichroism Lipid Bilayers - chemistry Lipid Bilayers - metabolism lipid-peptide interactions Membranes Molecular dynamics Molecular Dynamics Simulation Optical activity peptaibols Peptaibols - chemistry Peptaibols - metabolism Peptides Phosphatidylcholines - chemistry Phospholipids Raman spectroscopy Stereoisomerism Theoretical analysis transfer of chirality
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