Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression
Aim Patients with major depression present with an increased serum insulin‐like growth factor‐1 (IGF‐1) concentration. However, the longitudinal relationship between serum IGF‐1 levels and depression development remains unclear. This study aimed to investigate the longitudinal association between th...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2021-05, Vol.75 (5), p.159-165 |
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| creator | Adachi, Sho Tokuda, Narumi Kobayashi, Yoshiko Tanaka, Hiroyuki Sawai, Hideaki Shibahara, Hiroaki Takeshima, Yasuhiro Shima, Masayuki |
| description | Aim
Patients with major depression present with an increased serum insulin‐like growth factor‐1 (IGF‐1) concentration. However, the longitudinal relationship between serum IGF‐1 levels and depression development remains unclear. This study aimed to investigate the longitudinal association between the serum IGF‐1 concentration in the first trimester of pregnancy and postpartum depression development using data obtained from the Japan Environment and Children's Study (JECS).
Methods
The JECS included 97 415 pregnant women; among them, 8791 were enrolled in this study. Data regarding depression in the first trimester, postpartum depression development at 1 month after childbirth, and other covariates were collected using a self‐administered questionnaire. Serum IGF‐1 levels were measured in the first trimester of pregnancy. The participants were divided into four groups according to the serum IGF‐1 level.
Results
In the first trimester, serum IGF‐1 levels were not significantly associated with psychological distress in pregnant women. In the longitudinal analyses, however, postpartum depression development in mothers within the highest quartile for serum IGF‐1 concentration in the first trimester was significantly less common than in those within the lowest quartile (odds ratio 0.48, 95% confidence interval 0.30–0.79).
Conclusion
Pregnant women with a high serum IGF‐1 concentration in the first trimester were less likely to develop postpartum depression than those with a low concentration. A high serum IGF‐1 concentration during pregnancy may help to protect against postpartum depression development. |
| doi_str_mv | 10.1111/pcn.13200 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8248044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2520674222</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5330-700dd5ad66120216d85983657c02522f5bb6b46f69c215089fcfb14db84dd20c3</originalsourceid><addsrcrecordid>eNp1kbtuFDEUhi0EIhcoeAFkiYYUk_g2Hk-DFK0IRIqAAmrL48uuw6w92B5W21Gn4hl5EkwmRICEG1s-3_nPf_QD8AyjU1zP2aTDKaYEoQfgEDOGGixw_7C-KaENppgfgKOcrxFClHL8GBxQytqeUXEIbs5zjtqr4mOAgy07awMsGwuzTfMW-pDn0Ycf376P_rOF6xR3ZQOd0iWm-omhjkHbUNIi4Jde51MusCS_tbnYBKODU7LroILeQxUMnGIuk0qlTjC2lnKu3U_AI6fGbJ_e3cfg08Xrj6u3zdX7N5er86tGt5SipkPImFYZzjFBBHMj2l5Q3nYakZYQ1w4DHxh3vNcEt0j0TrsBMzMIZgxBmh6DV4vuNA9baxb7o5yqXZX2Miov_64Ev5Hr-FUKwgRirAq8vBNI8ctcV5Rbn7UdRxVsnLMkrBNdJ1DbVfTFP-h1nFOo68lqFvGOEUIqdbJQOsWck3X3ZjCSvxKWNWF5m3Bln__p_p78HWkFzhZg50e7_7-S_LB6t0j-BPYttPc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2520674222</pqid></control><display><type>article</type><title>Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression</title><source>Wiley Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Freely Accessible Japanese Titles</source><source>Alma/SFX Local Collection</source><creator>Adachi, Sho ; Tokuda, Narumi ; Kobayashi, Yoshiko ; Tanaka, Hiroyuki ; Sawai, Hideaki ; Shibahara, Hiroaki ; Takeshima, Yasuhiro ; Shima, Masayuki</creator><creatorcontrib>Adachi, Sho ; Tokuda, Narumi ; Kobayashi, Yoshiko ; Tanaka, Hiroyuki ; Sawai, Hideaki ; Shibahara, Hiroaki ; Takeshima, Yasuhiro ; Shima, Masayuki ; Japan Environment and Children's Study Group ; the Japan Environment and Children's Study Group</creatorcontrib><description>Aim
Patients with major depression present with an increased serum insulin‐like growth factor‐1 (IGF‐1) concentration. However, the longitudinal relationship between serum IGF‐1 levels and depression development remains unclear. This study aimed to investigate the longitudinal association between the serum IGF‐1 concentration in the first trimester of pregnancy and postpartum depression development using data obtained from the Japan Environment and Children's Study (JECS).
Methods
The JECS included 97 415 pregnant women; among them, 8791 were enrolled in this study. Data regarding depression in the first trimester, postpartum depression development at 1 month after childbirth, and other covariates were collected using a self‐administered questionnaire. Serum IGF‐1 levels were measured in the first trimester of pregnancy. The participants were divided into four groups according to the serum IGF‐1 level.
Results
In the first trimester, serum IGF‐1 levels were not significantly associated with psychological distress in pregnant women. In the longitudinal analyses, however, postpartum depression development in mothers within the highest quartile for serum IGF‐1 concentration in the first trimester was significantly less common than in those within the lowest quartile (odds ratio 0.48, 95% confidence interval 0.30–0.79).
Conclusion
Pregnant women with a high serum IGF‐1 concentration in the first trimester were less likely to develop postpartum depression than those with a low concentration. A high serum IGF‐1 concentration during pregnancy may help to protect against postpartum depression development.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/pcn.13200</identifier><identifier>PMID: 33459438</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>birth cohort ; Growth factors ; Insulin ; Insulin-like growth factors ; insulin‐like growth factor‐1 ; Japan Environment and Children's Study ; Mental depression ; Postpartum ; Postpartum depression ; Pregnancy ; pregnant women ; Regular ; Womens health</subject><ispartof>Psychiatry and clinical neurosciences, 2021-05, Vol.75 (5), p.159-165</ispartof><rights>2021 The Authors Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology</rights><rights>2021 The Authors Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5330-700dd5ad66120216d85983657c02522f5bb6b46f69c215089fcfb14db84dd20c3</citedby><cites>FETCH-LOGICAL-c5330-700dd5ad66120216d85983657c02522f5bb6b46f69c215089fcfb14db84dd20c3</cites><orcidid>0000-0002-8783-7879</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcn.13200$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcn.13200$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33459438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adachi, Sho</creatorcontrib><creatorcontrib>Tokuda, Narumi</creatorcontrib><creatorcontrib>Kobayashi, Yoshiko</creatorcontrib><creatorcontrib>Tanaka, Hiroyuki</creatorcontrib><creatorcontrib>Sawai, Hideaki</creatorcontrib><creatorcontrib>Shibahara, Hiroaki</creatorcontrib><creatorcontrib>Takeshima, Yasuhiro</creatorcontrib><creatorcontrib>Shima, Masayuki</creatorcontrib><creatorcontrib>Japan Environment and Children's Study Group</creatorcontrib><creatorcontrib>the Japan Environment and Children's Study Group</creatorcontrib><title>Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>Aim
Patients with major depression present with an increased serum insulin‐like growth factor‐1 (IGF‐1) concentration. However, the longitudinal relationship between serum IGF‐1 levels and depression development remains unclear. This study aimed to investigate the longitudinal association between the serum IGF‐1 concentration in the first trimester of pregnancy and postpartum depression development using data obtained from the Japan Environment and Children's Study (JECS).
Methods
The JECS included 97 415 pregnant women; among them, 8791 were enrolled in this study. Data regarding depression in the first trimester, postpartum depression development at 1 month after childbirth, and other covariates were collected using a self‐administered questionnaire. Serum IGF‐1 levels were measured in the first trimester of pregnancy. The participants were divided into four groups according to the serum IGF‐1 level.
Results
In the first trimester, serum IGF‐1 levels were not significantly associated with psychological distress in pregnant women. In the longitudinal analyses, however, postpartum depression development in mothers within the highest quartile for serum IGF‐1 concentration in the first trimester was significantly less common than in those within the lowest quartile (odds ratio 0.48, 95% confidence interval 0.30–0.79).
Conclusion
Pregnant women with a high serum IGF‐1 concentration in the first trimester were less likely to develop postpartum depression than those with a low concentration. A high serum IGF‐1 concentration during pregnancy may help to protect against postpartum depression development.</description><subject>birth cohort</subject><subject>Growth factors</subject><subject>Insulin</subject><subject>Insulin-like growth factors</subject><subject>insulin‐like growth factor‐1</subject><subject>Japan Environment and Children's Study</subject><subject>Mental depression</subject><subject>Postpartum</subject><subject>Postpartum depression</subject><subject>Pregnancy</subject><subject>pregnant women</subject><subject>Regular</subject><subject>Womens health</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kbtuFDEUhi0EIhcoeAFkiYYUk_g2Hk-DFK0IRIqAAmrL48uuw6w92B5W21Gn4hl5EkwmRICEG1s-3_nPf_QD8AyjU1zP2aTDKaYEoQfgEDOGGixw_7C-KaENppgfgKOcrxFClHL8GBxQytqeUXEIbs5zjtqr4mOAgy07awMsGwuzTfMW-pDn0Ycf376P_rOF6xR3ZQOd0iWm-omhjkHbUNIi4Jde51MusCS_tbnYBKODU7LroILeQxUMnGIuk0qlTjC2lnKu3U_AI6fGbJ_e3cfg08Xrj6u3zdX7N5er86tGt5SipkPImFYZzjFBBHMj2l5Q3nYakZYQ1w4DHxh3vNcEt0j0TrsBMzMIZgxBmh6DV4vuNA9baxb7o5yqXZX2Miov_64Ev5Hr-FUKwgRirAq8vBNI8ctcV5Rbn7UdRxVsnLMkrBNdJ1DbVfTFP-h1nFOo68lqFvGOEUIqdbJQOsWck3X3ZjCSvxKWNWF5m3Bln__p_p78HWkFzhZg50e7_7-S_LB6t0j-BPYttPc</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Adachi, Sho</creator><creator>Tokuda, Narumi</creator><creator>Kobayashi, Yoshiko</creator><creator>Tanaka, Hiroyuki</creator><creator>Sawai, Hideaki</creator><creator>Shibahara, Hiroaki</creator><creator>Takeshima, Yasuhiro</creator><creator>Shima, Masayuki</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8783-7879</orcidid></search><sort><creationdate>202105</creationdate><title>Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression</title><author>Adachi, Sho ; Tokuda, Narumi ; Kobayashi, Yoshiko ; Tanaka, Hiroyuki ; Sawai, Hideaki ; Shibahara, Hiroaki ; Takeshima, Yasuhiro ; Shima, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5330-700dd5ad66120216d85983657c02522f5bb6b46f69c215089fcfb14db84dd20c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>birth cohort</topic><topic>Growth factors</topic><topic>Insulin</topic><topic>Insulin-like growth factors</topic><topic>insulin‐like growth factor‐1</topic><topic>Japan Environment and Children's Study</topic><topic>Mental depression</topic><topic>Postpartum</topic><topic>Postpartum depression</topic><topic>Pregnancy</topic><topic>pregnant women</topic><topic>Regular</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adachi, Sho</creatorcontrib><creatorcontrib>Tokuda, Narumi</creatorcontrib><creatorcontrib>Kobayashi, Yoshiko</creatorcontrib><creatorcontrib>Tanaka, Hiroyuki</creatorcontrib><creatorcontrib>Sawai, Hideaki</creatorcontrib><creatorcontrib>Shibahara, Hiroaki</creatorcontrib><creatorcontrib>Takeshima, Yasuhiro</creatorcontrib><creatorcontrib>Shima, Masayuki</creatorcontrib><creatorcontrib>Japan Environment and Children's Study Group</creatorcontrib><creatorcontrib>the Japan Environment and Children's Study Group</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adachi, Sho</au><au>Tokuda, Narumi</au><au>Kobayashi, Yoshiko</au><au>Tanaka, Hiroyuki</au><au>Sawai, Hideaki</au><au>Shibahara, Hiroaki</au><au>Takeshima, Yasuhiro</au><au>Shima, Masayuki</au><aucorp>Japan Environment and Children's Study Group</aucorp><aucorp>the Japan Environment and Children's Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2021-05</date><risdate>2021</risdate><volume>75</volume><issue>5</issue><spage>159</spage><epage>165</epage><pages>159-165</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>Aim
Patients with major depression present with an increased serum insulin‐like growth factor‐1 (IGF‐1) concentration. However, the longitudinal relationship between serum IGF‐1 levels and depression development remains unclear. This study aimed to investigate the longitudinal association between the serum IGF‐1 concentration in the first trimester of pregnancy and postpartum depression development using data obtained from the Japan Environment and Children's Study (JECS).
Methods
The JECS included 97 415 pregnant women; among them, 8791 were enrolled in this study. Data regarding depression in the first trimester, postpartum depression development at 1 month after childbirth, and other covariates were collected using a self‐administered questionnaire. Serum IGF‐1 levels were measured in the first trimester of pregnancy. The participants were divided into four groups according to the serum IGF‐1 level.
Results
In the first trimester, serum IGF‐1 levels were not significantly associated with psychological distress in pregnant women. In the longitudinal analyses, however, postpartum depression development in mothers within the highest quartile for serum IGF‐1 concentration in the first trimester was significantly less common than in those within the lowest quartile (odds ratio 0.48, 95% confidence interval 0.30–0.79).
Conclusion
Pregnant women with a high serum IGF‐1 concentration in the first trimester were less likely to develop postpartum depression than those with a low concentration. A high serum IGF‐1 concentration during pregnancy may help to protect against postpartum depression development.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>33459438</pmid><doi>10.1111/pcn.13200</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8783-7879</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1323-1316 |
| ispartof | Psychiatry and clinical neurosciences, 2021-05, Vol.75 (5), p.159-165 |
| issn | 1323-1316 1440-1819 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8248044 |
| source | Wiley Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Freely Accessible Japanese Titles; Alma/SFX Local Collection |
| subjects | birth cohort Growth factors Insulin Insulin-like growth factors insulin‐like growth factor‐1 Japan Environment and Children's Study Mental depression Postpartum Postpartum depression Pregnancy pregnant women Regular Womens health |
| title | Association between the serum insulin‐like growth factor‐1 concentration in the first trimester of pregnancy and postpartum depression |
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