Impaired Inhibitory Control of Saccadic Eye Movements in Cervical Dystonia: An Eye‐Tracking Study
Background The pathophysiology of cervical dystonia is still unclear. Recent evidence points toward a network disorder affecting several brain areas. The objective of this study was to assess the saccadic inhibition as a marker of corticostriatal function in cervical dystonia. Methods We recruited 3...
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| Veröffentlicht in: | Movement disorders 2021-05, Vol.36 (5), p.1246-1250 |
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| creator | Carbone, Federico Ellmerer, Philipp Ritter, Marcel Spielberger, Sabine Mahlknecht, Philipp Hametner, Eva Hussl, Anna Hotter, Anna Granata, Roberta Seppi, Klaus Boesch, Sylvia Poewe, Werner Djamshidian, Atbin |
| description | Background
The pathophysiology of cervical dystonia is still unclear. Recent evidence points toward a network disorder affecting several brain areas. The objective of this study was to assess the saccadic inhibition as a marker of corticostriatal function in cervical dystonia.
Methods
We recruited 31 cervical dystonia patients and 17 matched healthy controls. Subjects performed an overlap prosaccade, an antisaccade, and a countermanding task on an eye tracker to assess automatic visual response and response inhibition.
Results
Cervical dystonia patients made more premature saccades (P = 0.041) in the overlap prosaccade task and more directional errors in the antisaccade task (P = 0.011) and had a higher rate of failed inhibition in the countermanding task (P = 0.001).
Conclusions
The results suggest altered saccadic inhibition in cervical dystonia, possibly as a consequence of dysfunctional corticostriatal networks. Further studies are warranted to confirm whether these abnormalities are affected by the available therapies and whether this type of impairment is found in other focal dystonias. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| doi_str_mv | 10.1002/mds.28486 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8247854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2527578990</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4436-b8e01df36e69611e21101f0c1d461e8ebc651aafdfb1b4e90b7b69950a158e163</originalsourceid><addsrcrecordid>eNp10c1u1DAUBWALgehQWPACyBIbWKT1TWLHYYFUTX8YqRWLKWvLcW5al8Qe7GRQdjwCz8iT4DKlKpVYeXE_HR3rEPIa2AEwlh8ObTzIZSnFE7IAXkAmc149JQsmJc8KkHyPvIjxhjEADuI52SuKEgTU9YKY1bDRNmBLV-7aNnb0YaZL78bge-o7utbG6NYaejIjvfBbHNCNkVpHlxi21uieHs9x9M7qD_TI3bJfP35eBm2-WndF1-PUzi_Js073EV_dvfvky-nJ5fJTdv75bLU8Os9MWRYiayQyaLtCoKgFAOYADDpmoC0FoMTGCA5ad23XQFNizZqqEXXNmQYuEUSxTz7ucjdTM2BrUtOge7UJdtBhVl5b9e_F2Wt15bdK5mUleZkC3t0FBP9twjiqwUaDfa8d-imqxAQXFSvyRN8-ojd-Ci59T-U8r3gl65ol9X6nTPAxBuzuywBTt9OpNJ36M12ybx62v5d_t0rgcAe-2x7n_yepi-P1LvI3XGSkZg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2527578990</pqid></control><display><type>article</type><title>Impaired Inhibitory Control of Saccadic Eye Movements in Cervical Dystonia: An Eye‐Tracking Study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Carbone, Federico ; Ellmerer, Philipp ; Ritter, Marcel ; Spielberger, Sabine ; Mahlknecht, Philipp ; Hametner, Eva ; Hussl, Anna ; Hotter, Anna ; Granata, Roberta ; Seppi, Klaus ; Boesch, Sylvia ; Poewe, Werner ; Djamshidian, Atbin</creator><creatorcontrib>Carbone, Federico ; Ellmerer, Philipp ; Ritter, Marcel ; Spielberger, Sabine ; Mahlknecht, Philipp ; Hametner, Eva ; Hussl, Anna ; Hotter, Anna ; Granata, Roberta ; Seppi, Klaus ; Boesch, Sylvia ; Poewe, Werner ; Djamshidian, Atbin</creatorcontrib><description>Background
The pathophysiology of cervical dystonia is still unclear. Recent evidence points toward a network disorder affecting several brain areas. The objective of this study was to assess the saccadic inhibition as a marker of corticostriatal function in cervical dystonia.
Methods
We recruited 31 cervical dystonia patients and 17 matched healthy controls. Subjects performed an overlap prosaccade, an antisaccade, and a countermanding task on an eye tracker to assess automatic visual response and response inhibition.
Results
Cervical dystonia patients made more premature saccades (P = 0.041) in the overlap prosaccade task and more directional errors in the antisaccade task (P = 0.011) and had a higher rate of failed inhibition in the countermanding task (P = 0.001).
Conclusions
The results suggest altered saccadic inhibition in cervical dystonia, possibly as a consequence of dysfunctional corticostriatal networks. Further studies are warranted to confirm whether these abnormalities are affected by the available therapies and whether this type of impairment is found in other focal dystonias. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.28486</identifier><identifier>PMID: 33416199</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Brain ; Brief Report ; cervical dystonia ; Dystonia ; eye tracking ; Eye-Tracking Technology ; Humans ; Inhibition, Psychological ; Movement disorders ; Neck ; Poisons ; prefrontal cortex ; Regular Issue ; Saccades ; Saccadic eye movements ; saccadic inhibition ; Torticollis</subject><ispartof>Movement disorders, 2021-05, Vol.36 (5), p.1246-1250</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</rights><rights>2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-b8e01df36e69611e21101f0c1d461e8ebc651aafdfb1b4e90b7b69950a158e163</citedby><cites>FETCH-LOGICAL-c4436-b8e01df36e69611e21101f0c1d461e8ebc651aafdfb1b4e90b7b69950a158e163</cites><orcidid>0000-0002-6909-0150 ; 0000-0003-0671-0516</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.28486$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.28486$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33416199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carbone, Federico</creatorcontrib><creatorcontrib>Ellmerer, Philipp</creatorcontrib><creatorcontrib>Ritter, Marcel</creatorcontrib><creatorcontrib>Spielberger, Sabine</creatorcontrib><creatorcontrib>Mahlknecht, Philipp</creatorcontrib><creatorcontrib>Hametner, Eva</creatorcontrib><creatorcontrib>Hussl, Anna</creatorcontrib><creatorcontrib>Hotter, Anna</creatorcontrib><creatorcontrib>Granata, Roberta</creatorcontrib><creatorcontrib>Seppi, Klaus</creatorcontrib><creatorcontrib>Boesch, Sylvia</creatorcontrib><creatorcontrib>Poewe, Werner</creatorcontrib><creatorcontrib>Djamshidian, Atbin</creatorcontrib><title>Impaired Inhibitory Control of Saccadic Eye Movements in Cervical Dystonia: An Eye‐Tracking Study</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>Background
The pathophysiology of cervical dystonia is still unclear. Recent evidence points toward a network disorder affecting several brain areas. The objective of this study was to assess the saccadic inhibition as a marker of corticostriatal function in cervical dystonia.
Methods
We recruited 31 cervical dystonia patients and 17 matched healthy controls. Subjects performed an overlap prosaccade, an antisaccade, and a countermanding task on an eye tracker to assess automatic visual response and response inhibition.
Results
Cervical dystonia patients made more premature saccades (P = 0.041) in the overlap prosaccade task and more directional errors in the antisaccade task (P = 0.011) and had a higher rate of failed inhibition in the countermanding task (P = 0.001).
Conclusions
The results suggest altered saccadic inhibition in cervical dystonia, possibly as a consequence of dysfunctional corticostriatal networks. Further studies are warranted to confirm whether these abnormalities are affected by the available therapies and whether this type of impairment is found in other focal dystonias. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</description><subject>Brain</subject><subject>Brief Report</subject><subject>cervical dystonia</subject><subject>Dystonia</subject><subject>eye tracking</subject><subject>Eye-Tracking Technology</subject><subject>Humans</subject><subject>Inhibition, Psychological</subject><subject>Movement disorders</subject><subject>Neck</subject><subject>Poisons</subject><subject>prefrontal cortex</subject><subject>Regular Issue</subject><subject>Saccades</subject><subject>Saccadic eye movements</subject><subject>saccadic inhibition</subject><subject>Torticollis</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp10c1u1DAUBWALgehQWPACyBIbWKT1TWLHYYFUTX8YqRWLKWvLcW5al8Qe7GRQdjwCz8iT4DKlKpVYeXE_HR3rEPIa2AEwlh8ObTzIZSnFE7IAXkAmc149JQsmJc8KkHyPvIjxhjEADuI52SuKEgTU9YKY1bDRNmBLV-7aNnb0YaZL78bge-o7utbG6NYaejIjvfBbHNCNkVpHlxi21uieHs9x9M7qD_TI3bJfP35eBm2-WndF1-PUzi_Js073EV_dvfvky-nJ5fJTdv75bLU8Os9MWRYiayQyaLtCoKgFAOYADDpmoC0FoMTGCA5ad23XQFNizZqqEXXNmQYuEUSxTz7ucjdTM2BrUtOge7UJdtBhVl5b9e_F2Wt15bdK5mUleZkC3t0FBP9twjiqwUaDfa8d-imqxAQXFSvyRN8-ojd-Ci59T-U8r3gl65ol9X6nTPAxBuzuywBTt9OpNJ36M12ybx62v5d_t0rgcAe-2x7n_yepi-P1LvI3XGSkZg</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Carbone, Federico</creator><creator>Ellmerer, Philipp</creator><creator>Ritter, Marcel</creator><creator>Spielberger, Sabine</creator><creator>Mahlknecht, Philipp</creator><creator>Hametner, Eva</creator><creator>Hussl, Anna</creator><creator>Hotter, Anna</creator><creator>Granata, Roberta</creator><creator>Seppi, Klaus</creator><creator>Boesch, Sylvia</creator><creator>Poewe, Werner</creator><creator>Djamshidian, Atbin</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6909-0150</orcidid><orcidid>https://orcid.org/0000-0003-0671-0516</orcidid></search><sort><creationdate>202105</creationdate><title>Impaired Inhibitory Control of Saccadic Eye Movements in Cervical Dystonia: An Eye‐Tracking Study</title><author>Carbone, Federico ; Ellmerer, Philipp ; Ritter, Marcel ; Spielberger, Sabine ; Mahlknecht, Philipp ; Hametner, Eva ; Hussl, Anna ; Hotter, Anna ; Granata, Roberta ; Seppi, Klaus ; Boesch, Sylvia ; Poewe, Werner ; Djamshidian, Atbin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-b8e01df36e69611e21101f0c1d461e8ebc651aafdfb1b4e90b7b69950a158e163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brain</topic><topic>Brief Report</topic><topic>cervical dystonia</topic><topic>Dystonia</topic><topic>eye tracking</topic><topic>Eye-Tracking Technology</topic><topic>Humans</topic><topic>Inhibition, Psychological</topic><topic>Movement disorders</topic><topic>Neck</topic><topic>Poisons</topic><topic>prefrontal cortex</topic><topic>Regular Issue</topic><topic>Saccades</topic><topic>Saccadic eye movements</topic><topic>saccadic inhibition</topic><topic>Torticollis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carbone, Federico</creatorcontrib><creatorcontrib>Ellmerer, Philipp</creatorcontrib><creatorcontrib>Ritter, Marcel</creatorcontrib><creatorcontrib>Spielberger, Sabine</creatorcontrib><creatorcontrib>Mahlknecht, Philipp</creatorcontrib><creatorcontrib>Hametner, Eva</creatorcontrib><creatorcontrib>Hussl, Anna</creatorcontrib><creatorcontrib>Hotter, Anna</creatorcontrib><creatorcontrib>Granata, Roberta</creatorcontrib><creatorcontrib>Seppi, Klaus</creatorcontrib><creatorcontrib>Boesch, Sylvia</creatorcontrib><creatorcontrib>Poewe, Werner</creatorcontrib><creatorcontrib>Djamshidian, Atbin</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carbone, Federico</au><au>Ellmerer, Philipp</au><au>Ritter, Marcel</au><au>Spielberger, Sabine</au><au>Mahlknecht, Philipp</au><au>Hametner, Eva</au><au>Hussl, Anna</au><au>Hotter, Anna</au><au>Granata, Roberta</au><au>Seppi, Klaus</au><au>Boesch, Sylvia</au><au>Poewe, Werner</au><au>Djamshidian, Atbin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Inhibitory Control of Saccadic Eye Movements in Cervical Dystonia: An Eye‐Tracking Study</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2021-05</date><risdate>2021</risdate><volume>36</volume><issue>5</issue><spage>1246</spage><epage>1250</epage><pages>1246-1250</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Background
The pathophysiology of cervical dystonia is still unclear. Recent evidence points toward a network disorder affecting several brain areas. The objective of this study was to assess the saccadic inhibition as a marker of corticostriatal function in cervical dystonia.
Methods
We recruited 31 cervical dystonia patients and 17 matched healthy controls. Subjects performed an overlap prosaccade, an antisaccade, and a countermanding task on an eye tracker to assess automatic visual response and response inhibition.
Results
Cervical dystonia patients made more premature saccades (P = 0.041) in the overlap prosaccade task and more directional errors in the antisaccade task (P = 0.011) and had a higher rate of failed inhibition in the countermanding task (P = 0.001).
Conclusions
The results suggest altered saccadic inhibition in cervical dystonia, possibly as a consequence of dysfunctional corticostriatal networks. Further studies are warranted to confirm whether these abnormalities are affected by the available therapies and whether this type of impairment is found in other focal dystonias. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33416199</pmid><doi>10.1002/mds.28486</doi><tpages>35</tpages><orcidid>https://orcid.org/0000-0002-6909-0150</orcidid><orcidid>https://orcid.org/0000-0003-0671-0516</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Movement disorders, 2021-05, Vol.36 (5), p.1246-1250 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Brain Brief Report cervical dystonia Dystonia eye tracking Eye-Tracking Technology Humans Inhibition, Psychological Movement disorders Neck Poisons prefrontal cortex Regular Issue Saccades Saccadic eye movements saccadic inhibition Torticollis |
| title | Impaired Inhibitory Control of Saccadic Eye Movements in Cervical Dystonia: An Eye‐Tracking Study |
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