ACE I/D Polymorphism, Plasma ACE Levels, and Long-term Kidney Outcomes or All-Cause Death in Patients With Type 1 Diabetes

The deletion (D) allele of the insertion/deletion (I/D) polymorphism is a risk factor for diabetic kidney disease. We assessed its contribution to long-term kidney outcomes and all-cause death in patients with long-standing type 1 diabetes. A total of 1,155 participants from three French and Belgian...

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Veröffentlicht in:	Diabetes care 2021-06, Vol.44 (6), p.1377-1384
Hauptverfasser:	Abouleka, Yawa, Mohammedi, Kamel, Carpentier, Charlyne, Dubois, Severine, Gourdy, Pierre, Gautier, Jean-François, Roussel, Ronan, Scheen, André, Alhenc-Gelas, François, Hadjadj, Samy, Velho, Gilberto, Marre, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE I/D polymorphism Albuminuria - genetics Alleles Cardiology and cardiovascular system Death Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Diabetic Nephropathies - genetics End-stage renal disease Endocrinologie, métabolisme & nutrition Endocrinology, metabolism & nutrition Epidermal growth factor receptors Gene deletion Gene polymorphism Genotype & phenotype Glomerular Filtration Rate Human health and pathology Human health sciences Humans Insertion Kidney Kidney diseases kidney events Kidneys Life Sciences Mortality Pathophysiology/Complications Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - genetics Polymorphism Reclassification Research design Risk analysis Risk factors Sciences de la santé humaine type1 diabetes Urologie & néphrologie Urology & nephrology
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