Mtr4 RNA helicase structures and interactions

Mtr4 RNA helicase structures and interactions

Mtr4 is a Ski2-like RNA helicase that plays a central role in RNA surveillance and degradation pathways as an activator of the RNA exosome. Multiple crystallographic and cryo-EM studies over the past 10 years have revealed important insight into the Mtr4 structure and interactions with protein and n...

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Veröffentlicht in:Biological chemistry 2021-04, Vol.402 (5), p.605-616
Hauptverfasser: Olsen, Keith J., Johnson, Sean J.
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Sprache:eng
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Mtr4
RNA helicase
RNA surveillance
Ski2-like helicase
structure
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Johnson, Sean J.
description Mtr4 is a Ski2-like RNA helicase that plays a central role in RNA surveillance and degradation pathways as an activator of the RNA exosome. Multiple crystallographic and cryo-EM studies over the past 10 years have revealed important insight into the Mtr4 structure and interactions with protein and nucleic acid binding partners. These structures place Mtr4 at the center of a dynamic process that recruits RNA substrates and presents them to the exosome. In this review, we summarize the available Mtr4 structures and highlight gaps in our current understanding.
doi_str_mv 10.1515/hsz-2020-0329
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subjects Mtr4
RNA helicase
RNA surveillance
Ski2-like helicase
structure
title Mtr4 RNA helicase structures and interactions
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