The nociceptin/orphanin FQ receptor system as a target to alleviate cancer‐induced bone pain in rats: Model validation and pharmacological evaluation

Background and Purpose Cancer‐induced bone pain remains inadequately controlled, and current standard of care analgesics is accompanied by several side effects. Nociceptin/orphanin FQ peptide (NOP) receptor agonists have demonstrated broad analgesic properties in rodent neuropathic and inflammatory...

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Veröffentlicht in:	British journal of pharmacology 2021-05, Vol.178 (9), p.1995-2007
Hauptverfasser:	Sliepen, Sonny H.J., Korioth, Johanna, Christoph, Thomas, Tzschentke, Thomas M., Diaz‐delCastillo, Marta, Heegaard, Anne‐Marie, Rutten, Kris
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Analgesics Animals Bone cancer Bone Diseases Bone marrow Cancer Cytokines Dorsal root ganglia Filaments Gene expression Inflammation Inoculation Male Neoplasms Neuralgia Nociceptin Nociceptin Receptor Opioid Peptides Pain Pain - drug therapy Pain perception Phenotypes Rats Rats, Sprague-Dawley Receptor mechanisms Receptors, Opioid Research Paper Surgery The Molecular Pharmacology of Bone and Cancer‐related Bone Diseases–Research Paper
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