Obesity is associated with severe COVID-19 but not death: a dose−response meta-analysis
The coronavirus disease 2019 (COVID-19) epidemic is spreading globally. Studies revealed that obesity may affect the progression and prognosis of COVID-19 patients. The aim of the meta-analysis is to identify the prevalence and impact of obesity on COVID-19. Studies on obese COVID-19 patients were o...
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| Veröffentlicht in: | Epidemiology and infection 2021-01, Vol.149, p.e144, Article e144 |
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| creator | Deng, Linyan Zhang, Jiaoyue Wang, Mengyuan Chen, Lulu |
| description | The coronavirus disease 2019 (COVID-19) epidemic is spreading globally. Studies revealed that obesity may affect the progression and prognosis of COVID-19 patients. The aim of the meta-analysis is to identify the prevalence and impact of obesity on COVID-19. Studies on obese COVID-19 patients were obtained by searching PubMed, Cochrane Library databases and Web of Science databases, up to date to 5 June 2020. And the prevalence rate and the odds ratio (OR) of obesity with 95% confidence interval (CI) were used as comprehensive indicators for analysis using a random-effects model. A total of 6081 patients in 11 studies were included. The prevalence of obesity in patients with COVID-19 was 30% (95% CI 21–39%). Obese patients were 1.79 times more likely to develop severe COVID-19 than non-obese patients (OR 1.79, 95% CI 1.52–2.11, P < 0.0001, I2 = 0%). However obesity was not associated with death in COVID-19 patients (OR 1.05, 95% CI 0.65–1.71, P = 0.84, I2 = 66.6%). In dose−response analysis, it was estimated that COVID-19 patients had a 16% increased risk of invasive mechanical ventilation (OR 1.16, 95% CI 1.10–1.23, P < 0.0001) and a 20% increased risk of admission to ICU (OR 1.20, 95% CI 1.11–1.30, P < 0.0001) per 5 kg/m2 increase in BMI. In conclusion, obesity in COVID-19 patients is associated with severity, but not mortality. |
| doi_str_mv | 10.1017/S0950268820003179 |
| format | Article |
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Studies revealed that obesity may affect the progression and prognosis of COVID-19 patients. The aim of the meta-analysis is to identify the prevalence and impact of obesity on COVID-19. Studies on obese COVID-19 patients were obtained by searching PubMed, Cochrane Library databases and Web of Science databases, up to date to 5 June 2020. And the prevalence rate and the odds ratio (OR) of obesity with 95% confidence interval (CI) were used as comprehensive indicators for analysis using a random-effects model. A total of 6081 patients in 11 studies were included. The prevalence of obesity in patients with COVID-19 was 30% (95% CI 21–39%). Obese patients were 1.79 times more likely to develop severe COVID-19 than non-obese patients (OR 1.79, 95% CI 1.52–2.11, P < 0.0001, I2 = 0%). However obesity was not associated with death in COVID-19 patients (OR 1.05, 95% CI 0.65–1.71, P = 0.84, I2 = 66.6%). In dose−response analysis, it was estimated that COVID-19 patients had a 16% increased risk of invasive mechanical ventilation (OR 1.16, 95% CI 1.10–1.23, P < 0.0001) and a 20% increased risk of admission to ICU (OR 1.20, 95% CI 1.11–1.30, P < 0.0001) per 5 kg/m2 increase in BMI. In conclusion, obesity in COVID-19 patients is associated with severity, but not mortality.</description><identifier>ISSN: 0950-2688</identifier><identifier>ISSN: 1469-4409</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268820003179</identifier><identifier>PMID: 33397542</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Body Mass Index ; Confidence intervals ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; COVID-19 - mortality ; Epidemics ; Hospitalization - statistics & numerical data ; Humans ; Mechanical ventilation ; Meta-analysis ; Mortality ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Original Paper ; Prevalence ; Risk Factors ; Severity of Illness Index ; Viral diseases</subject><ispartof>Epidemiology and infection, 2021-01, Vol.149, p.e144, Article e144</ispartof><rights>Copyright © The Author(s), 2021. Published by Cambridge University Press</rights><rights>Copyright © The Author(s), 2021. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Infect</addtitle><description>The coronavirus disease 2019 (COVID-19) epidemic is spreading globally. Studies revealed that obesity may affect the progression and prognosis of COVID-19 patients. The aim of the meta-analysis is to identify the prevalence and impact of obesity on COVID-19. Studies on obese COVID-19 patients were obtained by searching PubMed, Cochrane Library databases and Web of Science databases, up to date to 5 June 2020. And the prevalence rate and the odds ratio (OR) of obesity with 95% confidence interval (CI) were used as comprehensive indicators for analysis using a random-effects model. A total of 6081 patients in 11 studies were included. The prevalence of obesity in patients with COVID-19 was 30% (95% CI 21–39%). Obese patients were 1.79 times more likely to develop severe COVID-19 than non-obese patients (OR 1.79, 95% CI 1.52–2.11, P < 0.0001, I2 = 0%). However obesity was not associated with death in COVID-19 patients (OR 1.05, 95% CI 0.65–1.71, P = 0.84, I2 = 66.6%). In dose−response analysis, it was estimated that COVID-19 patients had a 16% increased risk of invasive mechanical ventilation (OR 1.16, 95% CI 1.10–1.23, P < 0.0001) and a 20% increased risk of admission to ICU (OR 1.20, 95% CI 1.11–1.30, P < 0.0001) per 5 kg/m2 increase in BMI. In conclusion, obesity in COVID-19 patients is associated with severity, but not mortality.</description><subject>Body Mass Index</subject><subject>Confidence intervals</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - mortality</subject><subject>Epidemics</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Mechanical ventilation</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Original Paper</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Viral diseases</subject><issn>0950-2688</issn><issn>1469-4409</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>IKXGN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctu1DAUhi0EotPCA7BBltiwCfiWOGaBVE0LrVRpFlwkVpYdn3RcJfFgO0XzBl3ziDwJHnVabmJ1Fv93_nP5EXpGyStKqHz9gaiasKZtGSGEU6keoAUVjaqEIOohWuzkaqcfoMOUrgqkWCsfowPOuZK1YAv0ZWUh-bzFPmGTUui8yeDwN5_XOME1RMDL1efzk4oqbOeMp5CxA5PXb7DBLiT4cfM9QtqEKQEeIZvKTGbYJp-eoEe9GRI83dcj9Ond6cflWXWxen--PL6oOiFprphta9mC5YJaantHLTQ161znaFnctQY6bnvjCkObppMNN4r1tK-VVNQIyY_Q21vfzWxHcB1MOZpBb6IfTdzqYLz-U5n8Wl-Ga90yUZepxeDl3iCGrzOkrEefOhgGM0GYk2aivIrQltcFffEXehXmWA4uVC14-S6vd4b0lupiSClCf78MJXoXnP4nuNLz_Pcr7jvukioA35ua0UbvLuHX7P_b_gQoxKOx</recordid><startdate>20210105</startdate><enddate>20210105</enddate><creator>Deng, Linyan</creator><creator>Zhang, Jiaoyue</creator><creator>Wang, Mengyuan</creator><creator>Chen, Lulu</creator><general>Cambridge University Press</general><scope>IKXGN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9185-0443</orcidid></search><sort><creationdate>20210105</creationdate><title>Obesity is associated with severe COVID-19 but not death: a dose−response meta-analysis</title><author>Deng, Linyan ; 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Infect</addtitle><date>2021-01-05</date><risdate>2021</risdate><volume>149</volume><spage>e144</spage><pages>e144-</pages><artnum>e144</artnum><issn>0950-2688</issn><issn>1469-4409</issn><eissn>1469-4409</eissn><abstract>The coronavirus disease 2019 (COVID-19) epidemic is spreading globally. Studies revealed that obesity may affect the progression and prognosis of COVID-19 patients. The aim of the meta-analysis is to identify the prevalence and impact of obesity on COVID-19. Studies on obese COVID-19 patients were obtained by searching PubMed, Cochrane Library databases and Web of Science databases, up to date to 5 June 2020. And the prevalence rate and the odds ratio (OR) of obesity with 95% confidence interval (CI) were used as comprehensive indicators for analysis using a random-effects model. A total of 6081 patients in 11 studies were included. The prevalence of obesity in patients with COVID-19 was 30% (95% CI 21–39%). Obese patients were 1.79 times more likely to develop severe COVID-19 than non-obese patients (OR 1.79, 95% CI 1.52–2.11, P < 0.0001, I2 = 0%). However obesity was not associated with death in COVID-19 patients (OR 1.05, 95% CI 0.65–1.71, P = 0.84, I2 = 66.6%). In dose−response analysis, it was estimated that COVID-19 patients had a 16% increased risk of invasive mechanical ventilation (OR 1.16, 95% CI 1.10–1.23, P < 0.0001) and a 20% increased risk of admission to ICU (OR 1.20, 95% CI 1.11–1.30, P < 0.0001) per 5 kg/m2 increase in BMI. In conclusion, obesity in COVID-19 patients is associated with severity, but not mortality.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>33397542</pmid><doi>10.1017/S0950268820003179</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9185-0443</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Body Mass Index Confidence intervals Coronaviruses COVID-19 COVID-19 - complications COVID-19 - epidemiology COVID-19 - mortality Epidemics Hospitalization - statistics & numerical data Humans Mechanical ventilation Meta-analysis Mortality Obesity Obesity - complications Obesity - epidemiology Original Paper Prevalence Risk Factors Severity of Illness Index Viral diseases |
| title | Obesity is associated with severe COVID-19 but not death: a dose−response meta-analysis |
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