Tissue-specific and transcription-dependent mechanisms regulate primary microRNA processing efficiency of the human chromosome 19 MicroRNA cluster

One of the longest human microRNA (miRNA) clusters is located on chromosome 19 (C19MC), containing 46 miRNA genes, which were considered to be expressed simultaneously and at similar levels from a common long noncoding transcript. Investigating the two tissue types where C19MC is exclusively express...

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Veröffentlicht in:	RNA biology 2021-08, Vol.18 (8), p.1170-1180
Hauptverfasser:	Fóthi, Ábel, Biró, Orsolya, Erdei, Zsuzsa, Apáti, Ágota, Orbán, Tamás I.
Format:	Artikel
Sprache:	eng
Schlagworte:	C19MC Cell Line, Tumor ChIP-qPCR Chromosomes, Human, Pair 19 - chemistry DGCR8 Drosha enhancer Enhancer Elements, Genetic Epigenesis, Genetic Female Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Humans MicroRNAs - genetics MicroRNAs - metabolism miRNA Multigene Family Organ Specificity Placenta - cytology Placenta - metabolism Pregnancy Research Paper Ribonuclease III - deficiency Ribonuclease III - genetics RNA Precursors - genetics RNA Precursors - metabolism RNA Processing, Post-Transcriptional Transcription, Genetic
Online-Zugang:	Volltext
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