Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study
Abstract Background Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear. Methods A prospective, multicenter cohort study was...
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| creator | Oi, Issei Ito, Isao Hirabayashi, Masataka Endo, Kazuo Emura, Masahito Kojima, Toru Tsukao, Hitokazu Tomii, Keisuke Nakagawa, Atsushi Otsuka, Kojiro Akai, Masaya Oi, Masahiro Sugita, Takakazu Fukui, Motonari Inoue, Daiki Hasegawa, Yoshinori Takahashi, Kenichi Yasui, Hiroaki Fujita, Kohei Ishida, Tadashi Ito, Akihiro Kita, Hideo Kaji, Yusuke Tsuchiya, Michiko Tomioka, Hiromi Yamada, Takashi Terada, Satoru Nakaji, Hitoshi Hamao, Nobuyoshi Shirata, Masahiro Nishioka, Kensuke Yamazoe, Masatoshi Shiraishi, Yusuke Ogimoto, Tatsuya Hosoya, Kazutaka Ajimizu, Hitomi Shima, Hiroshi Matsumoto, Hisako Tanabe, Naoya Hirai, Toyohiro |
| description | Abstract
Background
Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear.
Methods
A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP.
Results
Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P < .01), lower neutrophil-to-lymphocyte ratio (P < .01), lower systolic blood pressure (P < .01), higher diastolic blood pressure (P < .01), lower aspartate aminotransferase level (P < .05), higher serum sodium level (P < .05), and more frequent multilobar infiltrates (P < .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP.
Conclusions
Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings. |
| doi_str_mv | 10.1093/ofid/ofab282 |
| format | Article |
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Background
Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear.
Methods
A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP.
Results
Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P < .01), lower neutrophil-to-lymphocyte ratio (P < .01), lower systolic blood pressure (P < .01), higher diastolic blood pressure (P < .01), lower aspartate aminotransferase level (P < .05), higher serum sodium level (P < .05), and more frequent multilobar infiltrates (P < .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP.
Conclusions
Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings.]]></description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofab282</identifier><identifier>PMID: 34291119</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aspartate ; Comparative analysis ; Coronaviruses ; Health aspects ; Hospital patients ; Influenza ; Influenza viruses ; Lung diseases, Obstructive ; Major ; Medical research ; Medicine, Experimental ; Prognosis ; Severe acute respiratory syndrome</subject><ispartof>Open Forum Infectious Diseases, 2021-07, Vol.8 (7), p.ofab282-ofab282</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2021</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-ae3bb5bc4bfc1379d5d014edb5416047824b1cf1dc6948605a2315e164d2b1b73</citedby><cites>FETCH-LOGICAL-c504t-ae3bb5bc4bfc1379d5d014edb5416047824b1cf1dc6948605a2315e164d2b1b73</cites><orcidid>0000-0002-5225-7911 ; 0000-0002-6902-9085</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244664/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244664/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Oi, Issei</creatorcontrib><creatorcontrib>Ito, Isao</creatorcontrib><creatorcontrib>Hirabayashi, Masataka</creatorcontrib><creatorcontrib>Endo, Kazuo</creatorcontrib><creatorcontrib>Emura, Masahito</creatorcontrib><creatorcontrib>Kojima, Toru</creatorcontrib><creatorcontrib>Tsukao, Hitokazu</creatorcontrib><creatorcontrib>Tomii, Keisuke</creatorcontrib><creatorcontrib>Nakagawa, Atsushi</creatorcontrib><creatorcontrib>Otsuka, Kojiro</creatorcontrib><creatorcontrib>Akai, Masaya</creatorcontrib><creatorcontrib>Oi, Masahiro</creatorcontrib><creatorcontrib>Sugita, Takakazu</creatorcontrib><creatorcontrib>Fukui, Motonari</creatorcontrib><creatorcontrib>Inoue, Daiki</creatorcontrib><creatorcontrib>Hasegawa, Yoshinori</creatorcontrib><creatorcontrib>Takahashi, Kenichi</creatorcontrib><creatorcontrib>Yasui, Hiroaki</creatorcontrib><creatorcontrib>Fujita, Kohei</creatorcontrib><creatorcontrib>Ishida, Tadashi</creatorcontrib><creatorcontrib>Ito, Akihiro</creatorcontrib><creatorcontrib>Kita, Hideo</creatorcontrib><creatorcontrib>Kaji, Yusuke</creatorcontrib><creatorcontrib>Tsuchiya, Michiko</creatorcontrib><creatorcontrib>Tomioka, Hiromi</creatorcontrib><creatorcontrib>Yamada, Takashi</creatorcontrib><creatorcontrib>Terada, Satoru</creatorcontrib><creatorcontrib>Nakaji, Hitoshi</creatorcontrib><creatorcontrib>Hamao, Nobuyoshi</creatorcontrib><creatorcontrib>Shirata, Masahiro</creatorcontrib><creatorcontrib>Nishioka, Kensuke</creatorcontrib><creatorcontrib>Yamazoe, Masatoshi</creatorcontrib><creatorcontrib>Shiraishi, Yusuke</creatorcontrib><creatorcontrib>Ogimoto, Tatsuya</creatorcontrib><creatorcontrib>Hosoya, Kazutaka</creatorcontrib><creatorcontrib>Ajimizu, Hitomi</creatorcontrib><creatorcontrib>Shima, Hiroshi</creatorcontrib><creatorcontrib>Matsumoto, Hisako</creatorcontrib><creatorcontrib>Tanabe, Naoya</creatorcontrib><creatorcontrib>Hirai, Toyohiro</creatorcontrib><title>Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study</title><title>Open Forum Infectious Diseases</title><description><![CDATA[Abstract
Background
Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear.
Methods
A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP.
Results
Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P < .01), lower neutrophil-to-lymphocyte ratio (P < .01), lower systolic blood pressure (P < .01), higher diastolic blood pressure (P < .01), lower aspartate aminotransferase level (P < .05), higher serum sodium level (P < .05), and more frequent multilobar infiltrates (P < .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP.
Conclusions
Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings.]]></description><subject>Aspartate</subject><subject>Comparative analysis</subject><subject>Coronaviruses</subject><subject>Health aspects</subject><subject>Hospital patients</subject><subject>Influenza</subject><subject>Influenza viruses</subject><subject>Lung diseases, Obstructive</subject><subject>Major</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Prognosis</subject><subject>Severe acute respiratory syndrome</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kU2LFDEQhhtR3GXdmz8gNz04ayqd9IcHYRhWXVhRXPUa8lG9RrqTNukMjr_eNDOIXiSQFFXv-6TgraqnQK-A9vXLMDhbLqVZxx5U56xm3abrRfvwr_qsukzpO6UUgAra9o-rs5qzHgD68-rnR495Ct4pslM5oSX6QO5wjxHJ1uQFySdMs4tqCbEMDt7GMCHZhRi82ruYE2FEeUtu_DBm9L8U-bp2X5EteZ_HxRn0C8ZimGZVKG6P5G7J9vCkejSoMeHl6b2ovry5_rx7t7n98PZmt73dGEH5slFYay204XowULe9FZYCR6sFh4bytmNcgxnAmqbnXUOFYjUIhIZbpkG39UX1-sids57QrutENco5uknFgwzKyX8n3n2T92EvC5k3DS-A5ydADD8ypkVOLhkcR-Ux5CSZELwWlMH619VReq9GlM4PoRBNORYnZ4LHwZX-tm2bYuo4FMOLo8HEkFLE4c9eQOUasFwDlqeAi_zZUR7y_H_lb1X3qFI</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Oi, Issei</creator><creator>Ito, Isao</creator><creator>Hirabayashi, Masataka</creator><creator>Endo, Kazuo</creator><creator>Emura, Masahito</creator><creator>Kojima, Toru</creator><creator>Tsukao, Hitokazu</creator><creator>Tomii, Keisuke</creator><creator>Nakagawa, Atsushi</creator><creator>Otsuka, Kojiro</creator><creator>Akai, Masaya</creator><creator>Oi, Masahiro</creator><creator>Sugita, Takakazu</creator><creator>Fukui, Motonari</creator><creator>Inoue, Daiki</creator><creator>Hasegawa, Yoshinori</creator><creator>Takahashi, Kenichi</creator><creator>Yasui, Hiroaki</creator><creator>Fujita, Kohei</creator><creator>Ishida, Tadashi</creator><creator>Ito, Akihiro</creator><creator>Kita, Hideo</creator><creator>Kaji, Yusuke</creator><creator>Tsuchiya, Michiko</creator><creator>Tomioka, Hiromi</creator><creator>Yamada, Takashi</creator><creator>Terada, Satoru</creator><creator>Nakaji, Hitoshi</creator><creator>Hamao, Nobuyoshi</creator><creator>Shirata, Masahiro</creator><creator>Nishioka, Kensuke</creator><creator>Yamazoe, Masatoshi</creator><creator>Shiraishi, Yusuke</creator><creator>Ogimoto, Tatsuya</creator><creator>Hosoya, 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Akihiro ; Kita, Hideo ; Kaji, Yusuke ; Tsuchiya, Michiko ; Tomioka, Hiromi ; Yamada, Takashi ; Terada, Satoru ; Nakaji, Hitoshi ; Hamao, Nobuyoshi ; Shirata, Masahiro ; Nishioka, Kensuke ; Yamazoe, Masatoshi ; Shiraishi, Yusuke ; Ogimoto, Tatsuya ; Hosoya, Kazutaka ; Ajimizu, Hitomi ; Shima, Hiroshi ; Matsumoto, Hisako ; Tanabe, Naoya ; Hirai, Toyohiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-ae3bb5bc4bfc1379d5d014edb5416047824b1cf1dc6948605a2315e164d2b1b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aspartate</topic><topic>Comparative analysis</topic><topic>Coronaviruses</topic><topic>Health aspects</topic><topic>Hospital patients</topic><topic>Influenza</topic><topic>Influenza viruses</topic><topic>Lung diseases, Obstructive</topic><topic>Major</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Prognosis</topic><topic>Severe acute respiratory syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oi, Issei</creatorcontrib><creatorcontrib>Ito, Isao</creatorcontrib><creatorcontrib>Hirabayashi, Masataka</creatorcontrib><creatorcontrib>Endo, Kazuo</creatorcontrib><creatorcontrib>Emura, Masahito</creatorcontrib><creatorcontrib>Kojima, Toru</creatorcontrib><creatorcontrib>Tsukao, Hitokazu</creatorcontrib><creatorcontrib>Tomii, Keisuke</creatorcontrib><creatorcontrib>Nakagawa, Atsushi</creatorcontrib><creatorcontrib>Otsuka, Kojiro</creatorcontrib><creatorcontrib>Akai, Masaya</creatorcontrib><creatorcontrib>Oi, Masahiro</creatorcontrib><creatorcontrib>Sugita, Takakazu</creatorcontrib><creatorcontrib>Fukui, Motonari</creatorcontrib><creatorcontrib>Inoue, Daiki</creatorcontrib><creatorcontrib>Hasegawa, Yoshinori</creatorcontrib><creatorcontrib>Takahashi, Kenichi</creatorcontrib><creatorcontrib>Yasui, 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Hisako</creatorcontrib><creatorcontrib>Tanabe, Naoya</creatorcontrib><creatorcontrib>Hirai, Toyohiro</creatorcontrib><collection>Access via Oxford University Press (Open Access Collection)</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oi, Issei</au><au>Ito, Isao</au><au>Hirabayashi, Masataka</au><au>Endo, Kazuo</au><au>Emura, Masahito</au><au>Kojima, Toru</au><au>Tsukao, Hitokazu</au><au>Tomii, Keisuke</au><au>Nakagawa, Atsushi</au><au>Otsuka, Kojiro</au><au>Akai, Masaya</au><au>Oi, Masahiro</au><au>Sugita, Takakazu</au><au>Fukui, Motonari</au><au>Inoue, Daiki</au><au>Hasegawa, Yoshinori</au><au>Takahashi, Kenichi</au><au>Yasui, Hiroaki</au><au>Fujita, Kohei</au><au>Ishida, Tadashi</au><au>Ito, Akihiro</au><au>Kita, Hideo</au><au>Kaji, Yusuke</au><au>Tsuchiya, Michiko</au><au>Tomioka, Hiromi</au><au>Yamada, Takashi</au><au>Terada, Satoru</au><au>Nakaji, Hitoshi</au><au>Hamao, Nobuyoshi</au><au>Shirata, Masahiro</au><au>Nishioka, Kensuke</au><au>Yamazoe, Masatoshi</au><au>Shiraishi, Yusuke</au><au>Ogimoto, Tatsuya</au><au>Hosoya, Kazutaka</au><au>Ajimizu, Hitomi</au><au>Shima, Hiroshi</au><au>Matsumoto, Hisako</au><au>Tanabe, Naoya</au><au>Hirai, Toyohiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study</atitle><jtitle>Open Forum Infectious Diseases</jtitle><date>2021-07-01</date><risdate>2021</risdate><volume>8</volume><issue>7</issue><spage>ofab282</spage><epage>ofab282</epage><pages>ofab282-ofab282</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract><![CDATA[Abstract
Background
Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear.
Methods
A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP.
Results
Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P < .01), lower neutrophil-to-lymphocyte ratio (P < .01), lower systolic blood pressure (P < .01), higher diastolic blood pressure (P < .01), lower aspartate aminotransferase level (P < .05), higher serum sodium level (P < .05), and more frequent multilobar infiltrates (P < .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP.
Conclusions
Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings.]]></abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34291119</pmid><doi>10.1093/ofid/ofab282</doi><orcidid>https://orcid.org/0000-0002-5225-7911</orcidid><orcidid>https://orcid.org/0000-0002-6902-9085</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2328-8957 |
| ispartof | Open Forum Infectious Diseases, 2021-07, Vol.8 (7), p.ofab282-ofab282 |
| issn | 2328-8957 2328-8957 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8244664 |
| source | DOAJ Directory of Open Access Journals; Access via Oxford University Press (Open Access Collection); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aspartate Comparative analysis Coronaviruses Health aspects Hospital patients Influenza Influenza viruses Lung diseases, Obstructive Major Medical research Medicine, Experimental Prognosis Severe acute respiratory syndrome |
| title | Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study |
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