Enhanced Uptake of Processed Bovine β‐Lactoglobulin by Antigen Presenting Cells: Identification of Receptors and Implications for Allergenicity

Scope β‐lactoglobulin (BLG) is a major cow milk allergen encountered by the immune system of infants fed with milk‐based formulas. To determine the effect of processing on immunogenicity of BLG, this article characterized how heated and glycated BLG are recognized and internalized by APCs. Also, the...

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Veröffentlicht in:	Molecular nutrition & food research 2021-04, Vol.65 (8), p.e2000834-n/a
Hauptverfasser:	Teodorowicz, Malgorzata, Zenker, Hannah E., Ewaz, Arifa, Tsallis, Theodoros, Mauser, Andreas, Gensberger‐Reigl, Sabrina, Jong, Nicolette W., Hettinga, Kasper A., Wichers, Harry J., Neerven, R. J. Joost, Savelkoul, Huub F. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Advanced glycosylation end products aggregation of β‐lactoglobulin Allergenicity Allergens Antigen-presenting cells Antigens Binding CD36 antigen cow milk processing Cow's milk digestion of β‐lactoglobulin Digestive system Enzyme-linked immunosorbent assay galactin‐3 Maillard reaction ligands Gastrointestinal tract glycation of β‐lactoglobulin Glycosylation Hydrophobicity Immune system Immunogenicity Infants Internalization Lactoglobulin Lactose Milk RAGE Maillard reaction ligands Receptors Scavenger receptors β-Lactoglobulin
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