Uncovering targets of the Leader protease: Linking RNA‐mediated pathways and antiviral defense

RNA viruses have developed specialized mechanisms to subvert host RNA‐binding proteins (RBPs) favoring their own gene expression. The Leader (L) protein of foot‐and‐mouth disease virus, a member of the Picornaviridae family, is a papain‐like cysteine protease that self‐cleaves from the polyprotein....

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Veröffentlicht in:	Wiley interdisciplinary reviews. RNA 2021-07, Vol.12 (4), p.e1645-n/a
Hauptverfasser:	Saiz, Margarita, Martinez‐Salas, Encarnacion
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Restriction Factors - immunology Apoptosis Conserved sequence Cysteine proteinase Daxx protein Focus Foot-and-Mouth Disease Virus - enzymology Foot-and-Mouth Disease Virus - genetics Gemin5 Gene expression Immunity, Innate Initiation factors Interferon Leader protease targets LGP2 MDA5 Motor neurons Papain Protein sorting signals Proteolysis Retinoic acid RNA RNA Helicases RNA in Disease RNA viruses RNA‐binding proteins Signal transduction Transcription Translation Regulation
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