Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging
This report of the reddest emitting indium phosphide quantum dots (InP QDs) to date demonstrates tunable, near-infrared (NIR) photoluminescence (PL) as well as PL multiplexing in the first optical tissue window while avoiding toxic constituents. This synthesis overcomes the InP “growth bottleneck” a...
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| Veröffentlicht in: | Nano letters 2021-04, Vol.21 (7), p.3271-3279 |
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| container_title | Nano letters |
| container_volume | 21 |
| creator | Saeboe, Alexander M Nikiforov, Alexey Yu Toufanian, Reyhaneh Kays, Joshua C Chern, Margaret Casas, J. Paolo Han, Keyi Piryatinski, Andrei Jones, Dennis Dennis, Allison M |
| description | This report of the reddest emitting indium phosphide quantum dots (InP QDs) to date demonstrates tunable, near-infrared (NIR) photoluminescence (PL) as well as PL multiplexing in the first optical tissue window while avoiding toxic constituents. This synthesis overcomes the InP “growth bottleneck” and extends the emission peak of InP QDs deeper into the first optical tissue window using an inverted QD heterostructure, specifically ZnSe/InP/ZnS core/shell/shell nanoparticles. The QDs exhibit InP shell thickness-dependent tunable emission with peaks ranging from 515–845 nm. The high absorptivity of InP yields effective photoexcitation of the QDs with UV, visible, and NIR wavelengths. These nanoparticles extend the range of tunable direct-bandgap emission from InP-based nanostructures, effectively overcoming a synthetic barrier that has prevented InP-based QDs from reaching their full potential as NIR imaging agents. Multiplexed lymph node imaging in a mouse model demonstrates the potential of the NIR-emitting InP particles for in vivo imaging. |
| doi_str_mv | 10.1021/acs.nanolett.1c00600 |
| format | Article |
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Paolo ; Han, Keyi ; Piryatinski, Andrei ; Jones, Dennis ; Dennis, Allison M</creator><creatorcontrib>Saeboe, Alexander M ; Nikiforov, Alexey Yu ; Toufanian, Reyhaneh ; Kays, Joshua C ; Chern, Margaret ; Casas, J. Paolo ; Han, Keyi ; Piryatinski, Andrei ; Jones, Dennis ; Dennis, Allison M ; Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</creatorcontrib><description>This report of the reddest emitting indium phosphide quantum dots (InP QDs) to date demonstrates tunable, near-infrared (NIR) photoluminescence (PL) as well as PL multiplexing in the first optical tissue window while avoiding toxic constituents. This synthesis overcomes the InP “growth bottleneck” and extends the emission peak of InP QDs deeper into the first optical tissue window using an inverted QD heterostructure, specifically ZnSe/InP/ZnS core/shell/shell nanoparticles. The QDs exhibit InP shell thickness-dependent tunable emission with peaks ranging from 515–845 nm. The high absorptivity of InP yields effective photoexcitation of the QDs with UV, visible, and NIR wavelengths. These nanoparticles extend the range of tunable direct-bandgap emission from InP-based nanostructures, effectively overcoming a synthetic barrier that has prevented InP-based QDs from reaching their full potential as NIR imaging agents. 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The QDs exhibit InP shell thickness-dependent tunable emission with peaks ranging from 515–845 nm. The high absorptivity of InP yields effective photoexcitation of the QDs with UV, visible, and NIR wavelengths. These nanoparticles extend the range of tunable direct-bandgap emission from InP-based nanostructures, effectively overcoming a synthetic barrier that has prevented InP-based QDs from reaching their full potential as NIR imaging agents. Multiplexed lymph node imaging in a mouse model demonstrates the potential of the NIR-emitting InP particles for in vivo imaging.</description><subject>Animals</subject><subject>cadmium-free quantum dots</subject><subject>Indium</subject><subject>indium phosphide</subject><subject>inverted quantum dot</subject><subject>material science</subject><subject>Mice</subject><subject>NANOSCIENCE AND NANOTECHNOLOGY</subject><subject>Phosphines</subject><subject>preclinical imaging</subject><subject>Quantum Dots</subject><subject>quantum well</subject><subject>Zinc Compounds</subject><issn>1530-6984</issn><issn>1530-6992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u3CAURlHUKP9vEFWoe0_BYBtvKlXpNLGUtEnVdosYuB6T2jACHCVvH6JJRu2mKxCc77uIg9A5JQtKSvpR6bhwyvkRUlpQTUhNyB46ohUjRd225bvdXvBDdBzjPSGkZRU5QIeMNVXFBT1Cf5aPCZyxbo3TAPgbqFB0rg8qgMHLycZovcM_lFsD9j3uMjpP-HbwcTNYA_huVi7lky8-Rdz7gG_mMdnNCI853zn82z543E1qnSecov1ejRHOXtcT9Ovr8ufFVXH9_bK7-HxdKN7UqWhb0gjFa7ZiAnolSiVawxQ3K9MTCi03pRZMa21MLaAFoKpkDTcEdMkFADtBn7a9m3k1gdHgUlCj3AQ7qfAkvbLy3xtnB7n2D1KUnImqyQUftgU-Jiujtgn0oL1zoJOkgnNa1RniW0gHH2OAfjeAEvliSGZD8s2QfDWUY-__ftwu9KYkA2QLvMTv_Rxc_qv_dz4DV9KjgA</recordid><startdate>20210414</startdate><enddate>20210414</enddate><creator>Saeboe, Alexander M</creator><creator>Nikiforov, Alexey Yu</creator><creator>Toufanian, Reyhaneh</creator><creator>Kays, Joshua C</creator><creator>Chern, Margaret</creator><creator>Casas, J. 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Paolo</au><au>Han, Keyi</au><au>Piryatinski, Andrei</au><au>Jones, Dennis</au><au>Dennis, Allison M</au><aucorp>Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging</atitle><jtitle>Nano letters</jtitle><addtitle>Nano Lett</addtitle><date>2021-04-14</date><risdate>2021</risdate><volume>21</volume><issue>7</issue><spage>3271</spage><epage>3279</epage><pages>3271-3279</pages><issn>1530-6984</issn><eissn>1530-6992</eissn><abstract>This report of the reddest emitting indium phosphide quantum dots (InP QDs) to date demonstrates tunable, near-infrared (NIR) photoluminescence (PL) as well as PL multiplexing in the first optical tissue window while avoiding toxic constituents. 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| subjects | Animals cadmium-free quantum dots Indium indium phosphide inverted quantum dot material science Mice NANOSCIENCE AND NANOTECHNOLOGY Phosphines preclinical imaging Quantum Dots quantum well Zinc Compounds |
| title | Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging |
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