Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults
Objective: To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults. Methods: Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent cognitive testing, Center for Epidemiologic...
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| Veröffentlicht in: | Journal of geriatric psychiatry and neurology 2022-01, Vol.35 (1), p.145-154 |
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| container_title | Journal of geriatric psychiatry and neurology |
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| creator | Oyeyemi, Deborah M. Cooter, Mary Chung, Stacey Whitson, Heather E. Browndyke, Jeffrey N. Devinney, Michael J. Smith, Patrick J. Garrigues, Grant E. Moretti, Eugene Moul, Judd W. Cohen, Harvey Jay Mathew, Joseph P. Berger, Miles |
| description | Objective:
To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults.
Methods:
Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent cognitive testing, Center for Epidemiologic Studies-Depression, and State Anxiety Inventory screening before and 6 weeks after surgery. Cognitive test scores were combined by factor analysis into 4 cognitive domains, whose mean was defined as the continuous cognitive index (CCI). Postoperative global cognitive change was defined by CCI change from before to after surgery, with negative CCI change indicating worsened postoperative global cognition and vice versa.
Results:
Lower global cognition before surgery was associated with greater baseline depression severity (Spearman’s r = −0.30, p = 0.002) and baseline anxiety severity (Spearman’s r = −0.25, p = 0.010), and these associations were similar following surgery (r = −0.36, p < 0.001; r = −0.26, p = 0.008, respectively). Neither baseline depression or anxiety severity, nor postoperative changes in depression or anxiety severity, were associated with pre- to postoperative global cognitive change.
Conclusions:
Greater depression and anxiety severity were each associated with poorer cognitive performance both before and after surgery in older adults. Yet, neither baseline depression or anxiety symptoms, nor postoperative change in these symptoms, were associated with postoperative cognitive change. |
| doi_str_mv | 10.1177/0891988720978791 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8243391</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0891988720978791</sage_id><sourcerecordid>2474498843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-c929515f1c16f3ab3942879c0cf3b0b748cee841a98e9235983362faef29dad63</originalsourceid><addsrcrecordid>eNp1kUtvEzEUhS0EoiGwZ4W8ZDPUr8nYG6QQKCAVKvEQS8vxXKcOEzu1PYUs-ed4SKkAiZUln-8c-96D0GNKnlHadadEKqqk7BhRnewUvYNmtG1Z03ZE3kWzSW4m_QQ9yHlLCGmV5PfRCedcEiboDP34AIMpPoZ86ff4BZRvAAG_hH2CnOv16TJ891AO2IQer-Im-OKvAZ-NwU6u6nAxwS91gb8AfM146Qok_M5sY8LvY2hWJvXeWPxxTBtIB-wDvhj6iiz7cSj5IbrnzJDh0c05R5_PXn1avWnOL16_XS3PGyu4KI1VTLW0ddTSheNmzZVgdWRLrONrsu6EtABSUKMkKManQfmCOQOOqd70Cz5Hz4-5-3G9g95CKMkMep_8zqSDjsbrv5XgL_UmXmvJBOeK1oCnNwEpXo2Qi975bGEYTIA4Zs1EJ0TddqXniBxRm2LOCdztM5ToqTn9b3PV8uTP790afldVgeYIZLMBvY1jCnVd_w_8CSsboqs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2474498843</pqid></control><display><type>article</type><title>Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Oyeyemi, Deborah M. ; Cooter, Mary ; Chung, Stacey ; Whitson, Heather E. ; Browndyke, Jeffrey N. ; Devinney, Michael J. ; Smith, Patrick J. ; Garrigues, Grant E. ; Moretti, Eugene ; Moul, Judd W. ; Cohen, Harvey Jay ; Mathew, Joseph P. ; Berger, Miles</creator><creatorcontrib>Oyeyemi, Deborah M. ; Cooter, Mary ; Chung, Stacey ; Whitson, Heather E. ; Browndyke, Jeffrey N. ; Devinney, Michael J. ; Smith, Patrick J. ; Garrigues, Grant E. ; Moretti, Eugene ; Moul, Judd W. ; Cohen, Harvey Jay ; Mathew, Joseph P. ; Berger, Miles ; MADCO-PC Study Team Investigators ; for the MADCO-PC Study Team Investigators</creatorcontrib><description>Objective:
To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults.
Methods:
Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent cognitive testing, Center for Epidemiologic Studies-Depression, and State Anxiety Inventory screening before and 6 weeks after surgery. Cognitive test scores were combined by factor analysis into 4 cognitive domains, whose mean was defined as the continuous cognitive index (CCI). Postoperative global cognitive change was defined by CCI change from before to after surgery, with negative CCI change indicating worsened postoperative global cognition and vice versa.
Results:
Lower global cognition before surgery was associated with greater baseline depression severity (Spearman’s r = −0.30, p = 0.002) and baseline anxiety severity (Spearman’s r = −0.25, p = 0.010), and these associations were similar following surgery (r = −0.36, p < 0.001; r = −0.26, p = 0.008, respectively). Neither baseline depression or anxiety severity, nor postoperative changes in depression or anxiety severity, were associated with pre- to postoperative global cognitive change.
Conclusions:
Greater depression and anxiety severity were each associated with poorer cognitive performance both before and after surgery in older adults. Yet, neither baseline depression or anxiety symptoms, nor postoperative change in these symptoms, were associated with postoperative cognitive change.</description><identifier>ISSN: 0891-9887</identifier><identifier>EISSN: 1552-5708</identifier><identifier>DOI: 10.1177/0891988720978791</identifier><identifier>PMID: 33380241</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Anxiety - epidemiology ; Cognition ; Depression - epidemiology ; Humans ; Neuropsychological Tests ; Prospective Studies</subject><ispartof>Journal of geriatric psychiatry and neurology, 2022-01, Vol.35 (1), p.145-154</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-c929515f1c16f3ab3942879c0cf3b0b748cee841a98e9235983362faef29dad63</citedby><cites>FETCH-LOGICAL-c434t-c929515f1c16f3ab3942879c0cf3b0b748cee841a98e9235983362faef29dad63</cites><orcidid>0000-0003-4142-7505 ; 0000-0001-9127-8822</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0891988720978791$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0891988720978791$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,780,784,885,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33380241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oyeyemi, Deborah M.</creatorcontrib><creatorcontrib>Cooter, Mary</creatorcontrib><creatorcontrib>Chung, Stacey</creatorcontrib><creatorcontrib>Whitson, Heather E.</creatorcontrib><creatorcontrib>Browndyke, Jeffrey N.</creatorcontrib><creatorcontrib>Devinney, Michael J.</creatorcontrib><creatorcontrib>Smith, Patrick J.</creatorcontrib><creatorcontrib>Garrigues, Grant E.</creatorcontrib><creatorcontrib>Moretti, Eugene</creatorcontrib><creatorcontrib>Moul, Judd W.</creatorcontrib><creatorcontrib>Cohen, Harvey Jay</creatorcontrib><creatorcontrib>Mathew, Joseph P.</creatorcontrib><creatorcontrib>Berger, Miles</creatorcontrib><creatorcontrib>MADCO-PC Study Team Investigators</creatorcontrib><creatorcontrib>for the MADCO-PC Study Team Investigators</creatorcontrib><title>Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults</title><title>Journal of geriatric psychiatry and neurology</title><addtitle>J Geriatr Psychiatry Neurol</addtitle><description>Objective:
To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults.
Methods:
Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent cognitive testing, Center for Epidemiologic Studies-Depression, and State Anxiety Inventory screening before and 6 weeks after surgery. Cognitive test scores were combined by factor analysis into 4 cognitive domains, whose mean was defined as the continuous cognitive index (CCI). Postoperative global cognitive change was defined by CCI change from before to after surgery, with negative CCI change indicating worsened postoperative global cognition and vice versa.
Results:
Lower global cognition before surgery was associated with greater baseline depression severity (Spearman’s r = −0.30, p = 0.002) and baseline anxiety severity (Spearman’s r = −0.25, p = 0.010), and these associations were similar following surgery (r = −0.36, p < 0.001; r = −0.26, p = 0.008, respectively). Neither baseline depression or anxiety severity, nor postoperative changes in depression or anxiety severity, were associated with pre- to postoperative global cognitive change.
Conclusions:
Greater depression and anxiety severity were each associated with poorer cognitive performance both before and after surgery in older adults. Yet, neither baseline depression or anxiety symptoms, nor postoperative change in these symptoms, were associated with postoperative cognitive change.</description><subject>Aged</subject><subject>Anxiety - epidemiology</subject><subject>Cognition</subject><subject>Depression - epidemiology</subject><subject>Humans</subject><subject>Neuropsychological Tests</subject><subject>Prospective Studies</subject><issn>0891-9887</issn><issn>1552-5708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtvEzEUhS0EoiGwZ4W8ZDPUr8nYG6QQKCAVKvEQS8vxXKcOEzu1PYUs-ed4SKkAiZUln-8c-96D0GNKnlHadadEKqqk7BhRnewUvYNmtG1Z03ZE3kWzSW4m_QQ9yHlLCGmV5PfRCedcEiboDP34AIMpPoZ86ff4BZRvAAG_hH2CnOv16TJ891AO2IQer-Im-OKvAZ-NwU6u6nAxwS91gb8AfM146Qok_M5sY8LvY2hWJvXeWPxxTBtIB-wDvhj6iiz7cSj5IbrnzJDh0c05R5_PXn1avWnOL16_XS3PGyu4KI1VTLW0ddTSheNmzZVgdWRLrONrsu6EtABSUKMkKManQfmCOQOOqd70Cz5Hz4-5-3G9g95CKMkMep_8zqSDjsbrv5XgL_UmXmvJBOeK1oCnNwEpXo2Qi975bGEYTIA4Zs1EJ0TddqXniBxRm2LOCdztM5ToqTn9b3PV8uTP790afldVgeYIZLMBvY1jCnVd_w_8CSsboqs</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Oyeyemi, Deborah M.</creator><creator>Cooter, Mary</creator><creator>Chung, Stacey</creator><creator>Whitson, Heather E.</creator><creator>Browndyke, Jeffrey N.</creator><creator>Devinney, Michael J.</creator><creator>Smith, Patrick J.</creator><creator>Garrigues, Grant E.</creator><creator>Moretti, Eugene</creator><creator>Moul, Judd W.</creator><creator>Cohen, Harvey Jay</creator><creator>Mathew, Joseph P.</creator><creator>Berger, Miles</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4142-7505</orcidid><orcidid>https://orcid.org/0000-0001-9127-8822</orcidid></search><sort><creationdate>20220101</creationdate><title>Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults</title><author>Oyeyemi, Deborah M. ; Cooter, Mary ; Chung, Stacey ; Whitson, Heather E. ; Browndyke, Jeffrey N. ; Devinney, Michael J. ; Smith, Patrick J. ; Garrigues, Grant E. ; Moretti, Eugene ; Moul, Judd W. ; Cohen, Harvey Jay ; Mathew, Joseph P. ; Berger, Miles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-c929515f1c16f3ab3942879c0cf3b0b748cee841a98e9235983362faef29dad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Anxiety - epidemiology</topic><topic>Cognition</topic><topic>Depression - epidemiology</topic><topic>Humans</topic><topic>Neuropsychological Tests</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oyeyemi, Deborah M.</creatorcontrib><creatorcontrib>Cooter, Mary</creatorcontrib><creatorcontrib>Chung, Stacey</creatorcontrib><creatorcontrib>Whitson, Heather E.</creatorcontrib><creatorcontrib>Browndyke, Jeffrey N.</creatorcontrib><creatorcontrib>Devinney, Michael J.</creatorcontrib><creatorcontrib>Smith, Patrick J.</creatorcontrib><creatorcontrib>Garrigues, Grant E.</creatorcontrib><creatorcontrib>Moretti, Eugene</creatorcontrib><creatorcontrib>Moul, Judd W.</creatorcontrib><creatorcontrib>Cohen, Harvey Jay</creatorcontrib><creatorcontrib>Mathew, Joseph P.</creatorcontrib><creatorcontrib>Berger, Miles</creatorcontrib><creatorcontrib>MADCO-PC Study Team Investigators</creatorcontrib><creatorcontrib>for the MADCO-PC Study Team Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of geriatric psychiatry and neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oyeyemi, Deborah M.</au><au>Cooter, Mary</au><au>Chung, Stacey</au><au>Whitson, Heather E.</au><au>Browndyke, Jeffrey N.</au><au>Devinney, Michael J.</au><au>Smith, Patrick J.</au><au>Garrigues, Grant E.</au><au>Moretti, Eugene</au><au>Moul, Judd W.</au><au>Cohen, Harvey Jay</au><au>Mathew, Joseph P.</au><au>Berger, Miles</au><aucorp>MADCO-PC Study Team Investigators</aucorp><aucorp>for the MADCO-PC Study Team Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults</atitle><jtitle>Journal of geriatric psychiatry and neurology</jtitle><addtitle>J Geriatr Psychiatry Neurol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>35</volume><issue>1</issue><spage>145</spage><epage>154</epage><pages>145-154</pages><issn>0891-9887</issn><eissn>1552-5708</eissn><abstract>Objective:
To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults.
Methods:
Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent cognitive testing, Center for Epidemiologic Studies-Depression, and State Anxiety Inventory screening before and 6 weeks after surgery. Cognitive test scores were combined by factor analysis into 4 cognitive domains, whose mean was defined as the continuous cognitive index (CCI). Postoperative global cognitive change was defined by CCI change from before to after surgery, with negative CCI change indicating worsened postoperative global cognition and vice versa.
Results:
Lower global cognition before surgery was associated with greater baseline depression severity (Spearman’s r = −0.30, p = 0.002) and baseline anxiety severity (Spearman’s r = −0.25, p = 0.010), and these associations were similar following surgery (r = −0.36, p < 0.001; r = −0.26, p = 0.008, respectively). Neither baseline depression or anxiety severity, nor postoperative changes in depression or anxiety severity, were associated with pre- to postoperative global cognitive change.
Conclusions:
Greater depression and anxiety severity were each associated with poorer cognitive performance both before and after surgery in older adults. Yet, neither baseline depression or anxiety symptoms, nor postoperative change in these symptoms, were associated with postoperative cognitive change.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>33380241</pmid><doi>10.1177/0891988720978791</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4142-7505</orcidid><orcidid>https://orcid.org/0000-0001-9127-8822</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0891-9887 |
| ispartof | Journal of geriatric psychiatry and neurology, 2022-01, Vol.35 (1), p.145-154 |
| issn | 0891-9887 1552-5708 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8243391 |
| source | Access via SAGE; MEDLINE |
| subjects | Aged Anxiety - epidemiology Cognition Depression - epidemiology Humans Neuropsychological Tests Prospective Studies |
| title | Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults |
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