Identification of known drugs as potential SARS-CoV-2 Mpro inhibitors using ligand- and structure-based virtual screening

The new coronavirus pandemic has had a significant impact worldwide, and therapeutic treatment for this viral infection is being strongly pursued. Efforts have been undertaken by medicinal chemists to discover molecules or known drugs that may be effective in COVID-19 treatment – in particular, targ...

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Veröffentlicht in:	Future medicinal chemistry 2021-08, Vol.13 (16), p.1353-1366
Hauptverfasser:	Federico, Leonardo Bruno, Silva, Guilherme Martins, da Silva Hage-Melim, Lorane Izabel, Gomes, Suzane Quintana, Barcelos, Mariana Pegrucci, Galindo Francischini, Isaque Antônio, Tomich de Paula da Silva, Carlos Henrique
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 drug repositioning ligand-based drug discovery main-protease (Mpro) SARS-CoV-2 structure-based drug discovery
Online-Zugang:	Volltext
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