Outcomes of gonioscopy-assisted transluminal trabeculotomy in pseudoexfoliative glaucoma: 24-month follow-up
AimTo report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with pseudoexfoliative glaucoma (PXG).MethodsProspective, interventional, non-comparative case series. A total of 103 eyes from 84 patients with PXG were enrolled to undergo a 360-degree ab interno trabeculotom...
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| Veröffentlicht in: | British journal of ophthalmology 2021-07, Vol.105 (7), p.977-982 |
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| creator | Sharkawi, Eamon Lindegger, Daniel Josef Artes, Paul H Lehmann-Clarke, Lydia El Wardani, Mohamad Misteli, Marie Pasquier, Jérôme Guarnieri, Adriano |
| description | AimTo report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with pseudoexfoliative glaucoma (PXG).MethodsProspective, interventional, non-comparative case series. A total of 103 eyes from 84 patients with PXG were enrolled to undergo a 360-degree ab interno trabeculotomy with gonioscopic assistance using either a 5.0 polypropylene suture or an illuminated microcatheter with up to 24 months of follow-up. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, success rate (IOP reduction ≥20% from baseline or IOP between 6 and 21 mm Hg, without further glaucoma surgery) and complication rate.ResultsMean preoperative IOP was 27.1 mm Hg (95% CI 25.5 to 28.7) using 2.9 (SD 1.1) glaucoma medications which decreased postoperatively to 13.0 mm Hg (95% CI 11.5 to 14.4) and 1.0 (SD 1.1) medications at 24 months (p |
| doi_str_mv | 10.1136/bjophthalmol-2020-315954 |
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A total of 103 eyes from 84 patients with PXG were enrolled to undergo a 360-degree ab interno trabeculotomy with gonioscopic assistance using either a 5.0 polypropylene suture or an illuminated microcatheter with up to 24 months of follow-up. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, success rate (IOP reduction ≥20% from baseline or IOP between 6 and 21 mm Hg, without further glaucoma surgery) and complication rate.ResultsMean preoperative IOP was 27.1 mm Hg (95% CI 25.5 to 28.7) using 2.9 (SD 1.1) glaucoma medications which decreased postoperatively to 13.0 mm Hg (95% CI 11.5 to 14.4) and 1.0 (SD 1.1) medications at 24 months (p<0.001). Success rate was 89.2% at 24 months of follow-up, and complication rate was 2.9%.ConclusionAt 24 months of follow-up, our results for GATT in PXG demonstrate that this conjunctival sparing procedure effectively lowers IOP and reduces the medications with a low complication rate, in this relatively aggressive glaucoma subtype.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjophthalmol-2020-315954</identifier><identifier>PMID: 32727734</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Cataracts ; Catheters ; Clinical Science ; Cornea ; Eye surgery ; Glaucoma ; Patients ; Viscoelasticity</subject><ispartof>British journal of ophthalmology, 2021-07, Vol.105 (7), p.977-982</ispartof><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b469t-593a3e2456dc240c50fb2e8433f1911a1b8a73e2dbce13205787a4912ebd32413</citedby><cites>FETCH-LOGICAL-b469t-593a3e2456dc240c50fb2e8433f1911a1b8a73e2dbce13205787a4912ebd32413</cites><orcidid>0000-0003-3574-8396 ; 0000-0002-5554-2988 ; 0000-0003-2871-3339</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237193/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237193/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Sharkawi, Eamon</creatorcontrib><creatorcontrib>Lindegger, Daniel Josef</creatorcontrib><creatorcontrib>Artes, Paul H</creatorcontrib><creatorcontrib>Lehmann-Clarke, Lydia</creatorcontrib><creatorcontrib>El Wardani, Mohamad</creatorcontrib><creatorcontrib>Misteli, Marie</creatorcontrib><creatorcontrib>Pasquier, Jérôme</creatorcontrib><creatorcontrib>Guarnieri, Adriano</creatorcontrib><title>Outcomes of gonioscopy-assisted transluminal trabeculotomy in pseudoexfoliative glaucoma: 24-month follow-up</title><title>British journal of ophthalmology</title><description>AimTo report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with pseudoexfoliative glaucoma (PXG).MethodsProspective, interventional, non-comparative case series. A total of 103 eyes from 84 patients with PXG were enrolled to undergo a 360-degree ab interno trabeculotomy with gonioscopic assistance using either a 5.0 polypropylene suture or an illuminated microcatheter with up to 24 months of follow-up. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, success rate (IOP reduction ≥20% from baseline or IOP between 6 and 21 mm Hg, without further glaucoma surgery) and complication rate.ResultsMean preoperative IOP was 27.1 mm Hg (95% CI 25.5 to 28.7) using 2.9 (SD 1.1) glaucoma medications which decreased postoperatively to 13.0 mm Hg (95% CI 11.5 to 14.4) and 1.0 (SD 1.1) medications at 24 months (p<0.001). Success rate was 89.2% at 24 months of follow-up, and complication rate was 2.9%.ConclusionAt 24 months of follow-up, our results for GATT in PXG demonstrate that this conjunctival sparing procedure effectively lowers IOP and reduces the medications with a low complication rate, in this relatively aggressive glaucoma subtype.</description><subject>Cataracts</subject><subject>Catheters</subject><subject>Clinical Science</subject><subject>Cornea</subject><subject>Eye surgery</subject><subject>Glaucoma</subject><subject>Patients</subject><subject>Viscoelasticity</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1v1DAQhi1ERZeW_2CJCxeDvxInHJBQxZdUqZf2bNmOs-uVnQlxXNh_j1epEHDiZI3ned8ZzYsQZvQtY6J9Z48wH9aDiQki4ZRTIljTN_IZ2jHZdvVL9c_RjlKqCGMtu0Qvcz7WkrdMvUCXgiuulJA7FO_K6iD5jGHEe5gCZAfziZicQ179gNfFTDmWFCYTz4X1rkRYIZ1wmPCcfRnA_xwhBrOGR4_30ZRqaN5jLkmCaT3g2ozwg5T5Gl2MJmb_6um9Qg-fP93ffCW3d1--3Xy8JVa2_UqaXhjhuWzawXFJXUNHy30nhRhZz5hhtjOqAoN1nglOG9UpI3vGvR0El0xcoQ-b71xs8oPzU1086nkJySwnDSbovztTOOg9POqOC8V6UQ3ePBks8L34vOoUsvMxmslDyZpL3tOm22a9_gc9QlnqsSrVSCk6KVtZqW6j3AI5L378vQyj-hyp_jNSfY5Ub5FWqdikNh3_X_ULkv-qkA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Sharkawi, Eamon</creator><creator>Lindegger, Daniel Josef</creator><creator>Artes, Paul H</creator><creator>Lehmann-Clarke, Lydia</creator><creator>El Wardani, Mohamad</creator><creator>Misteli, Marie</creator><creator>Pasquier, Jérôme</creator><creator>Guarnieri, Adriano</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3574-8396</orcidid><orcidid>https://orcid.org/0000-0002-5554-2988</orcidid><orcidid>https://orcid.org/0000-0003-2871-3339</orcidid></search><sort><creationdate>20210701</creationdate><title>Outcomes of gonioscopy-assisted transluminal trabeculotomy in pseudoexfoliative glaucoma: 24-month follow-up</title><author>Sharkawi, Eamon ; Lindegger, Daniel Josef ; Artes, Paul H ; Lehmann-Clarke, Lydia ; El Wardani, Mohamad ; Misteli, Marie ; Pasquier, Jérôme ; Guarnieri, Adriano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b469t-593a3e2456dc240c50fb2e8433f1911a1b8a73e2dbce13205787a4912ebd32413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cataracts</topic><topic>Catheters</topic><topic>Clinical Science</topic><topic>Cornea</topic><topic>Eye surgery</topic><topic>Glaucoma</topic><topic>Patients</topic><topic>Viscoelasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharkawi, Eamon</creatorcontrib><creatorcontrib>Lindegger, Daniel Josef</creatorcontrib><creatorcontrib>Artes, Paul H</creatorcontrib><creatorcontrib>Lehmann-Clarke, Lydia</creatorcontrib><creatorcontrib>El Wardani, Mohamad</creatorcontrib><creatorcontrib>Misteli, Marie</creatorcontrib><creatorcontrib>Pasquier, Jérôme</creatorcontrib><creatorcontrib>Guarnieri, Adriano</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharkawi, Eamon</au><au>Lindegger, Daniel Josef</au><au>Artes, Paul H</au><au>Lehmann-Clarke, Lydia</au><au>El Wardani, Mohamad</au><au>Misteli, Marie</au><au>Pasquier, Jérôme</au><au>Guarnieri, Adriano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of gonioscopy-assisted transluminal trabeculotomy in pseudoexfoliative glaucoma: 24-month follow-up</atitle><jtitle>British journal of ophthalmology</jtitle><date>2021-07-01</date><risdate>2021</risdate><volume>105</volume><issue>7</issue><spage>977</spage><epage>982</epage><pages>977-982</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><abstract>AimTo report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with pseudoexfoliative glaucoma (PXG).MethodsProspective, interventional, non-comparative case series. A total of 103 eyes from 84 patients with PXG were enrolled to undergo a 360-degree ab interno trabeculotomy with gonioscopic assistance using either a 5.0 polypropylene suture or an illuminated microcatheter with up to 24 months of follow-up. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, success rate (IOP reduction ≥20% from baseline or IOP between 6 and 21 mm Hg, without further glaucoma surgery) and complication rate.ResultsMean preoperative IOP was 27.1 mm Hg (95% CI 25.5 to 28.7) using 2.9 (SD 1.1) glaucoma medications which decreased postoperatively to 13.0 mm Hg (95% CI 11.5 to 14.4) and 1.0 (SD 1.1) medications at 24 months (p<0.001). Success rate was 89.2% at 24 months of follow-up, and complication rate was 2.9%.ConclusionAt 24 months of follow-up, our results for GATT in PXG demonstrate that this conjunctival sparing procedure effectively lowers IOP and reduces the medications with a low complication rate, in this relatively aggressive glaucoma subtype.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><pmid>32727734</pmid><doi>10.1136/bjophthalmol-2020-315954</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3574-8396</orcidid><orcidid>https://orcid.org/0000-0002-5554-2988</orcidid><orcidid>https://orcid.org/0000-0003-2871-3339</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cataracts Catheters Clinical Science Cornea Eye surgery Glaucoma Patients Viscoelasticity |
| title | Outcomes of gonioscopy-assisted transluminal trabeculotomy in pseudoexfoliative glaucoma: 24-month follow-up |
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