3-year Treatment of Tenofovir Alafenamide vs . Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China
Tenofovir alafenamide (TAF) has similar efficacy to tenofovir disoproxil fumarate (TDF) but with improved renal and bone safety in chronic hepatitis B patients studied outside of China. We report 3-year results from two phase 3 studies with TAF in China (Clinicaltrials.gov: NCT02836249 and NCT028362...
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| Veröffentlicht in: | Journal of clinical and translational hepatology 2021-06, Vol.9 (3), p.324-334 |
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| creator | Hou, Jinlin Ning, Qin Duan, Zhongping Chen, You Xie, Qing Wang, Fu-Sheng Zhang, Lunli Wu, Shanming Tang, Hong Li, Jun Lin, Feng Yang, Yongfeng Gong, Guozhong Flaherty, John F Gaggar, Anuj Mo, Shuyuan Cheng, Cong Camus, Gregory Chen, Chengwei Huang, Yan Jia, Jidong Zhang, Mingxiang |
| description | Tenofovir alafenamide (TAF) has similar efficacy to tenofovir disoproxil fumarate (TDF) but with improved renal and bone safety in chronic hepatitis B patients studied outside of China. We report 3-year results from two phase 3 studies with TAF in China (Clinicaltrials.gov: NCT02836249 and NCT02836236).
Chinese hepatitis B e antigen (HBeAg)-positive and -negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks (3 years). Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.
Of the 334 patients (180 HBeAg-positive and 154 HBeAg-negative) randomized and treated, baseline characteristics were similar between groups. The overall mean age was 38 years and 73% were male. The mean HBV DNA was 6.4 log
IU/mL. The median alanine aminotransferase was 88 U/L, and 37% had a history of antiviral use. At week 144, the proportion with HBV DNA |
| doi_str_mv | 10.14218/JCTH.2020.00145 |
| format | Article |
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Chinese hepatitis B e antigen (HBeAg)-positive and -negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks (3 years). Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.
Of the 334 patients (180 HBeAg-positive and 154 HBeAg-negative) randomized and treated, baseline characteristics were similar between groups. The overall mean age was 38 years and 73% were male. The mean HBV DNA was 6.4 log
IU/mL. The median alanine aminotransferase was 88 U/L, and 37% had a history of antiviral use. At week 144, the proportion with HBV DNA <29 IU/mL was similar among the two groups, with TAF at 83% vs. TDF at 79%, and TAF at 93% vs. TDF at 92% for the HBeAg-positive and -negative patients, respectively. In each study, higher proportions of TAF than TDF patients showed normalized alanine aminotransferase (via the American Association for the Study of Liver Diseases and the China criteria) and showed loss of HBsAg; meanwhile, the HBeAg seroconversion rates were similar. Treatment was well-tolerated among the TAF patients, who showed a smaller median decline in creatinine clearance (-0.4 vs. -3.2 mL/min;
=0.014) and less percentage change in bone mineral density vs. TDF at hip (-0.95% vs. -1.93%) and spine (+0.35% vs. -1.40%).
In chronic hepatitis B patients from China, TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years.</description><identifier>ISSN: 2225-0719</identifier><identifier>EISSN: 2310-8819</identifier><identifier>DOI: 10.14218/JCTH.2020.00145</identifier><identifier>PMID: 34221918</identifier><language>eng</language><publisher>China: XIA & HE Publishing Inc</publisher><subject>Original</subject><ispartof>Journal of clinical and translational hepatology, 2021-06, Vol.9 (3), p.324-334</ispartof><rights>2021 Authors.</rights><rights>2021 Authors. 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-dde98b48ad39b19b6b8667ca075dfb10f4bea263847578754a046534ea271b593</citedby><cites>FETCH-LOGICAL-c396t-dde98b48ad39b19b6b8667ca075dfb10f4bea263847578754a046534ea271b593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237145/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237145/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34221918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Jinlin</creatorcontrib><creatorcontrib>Ning, Qin</creatorcontrib><creatorcontrib>Duan, Zhongping</creatorcontrib><creatorcontrib>Chen, You</creatorcontrib><creatorcontrib>Xie, Qing</creatorcontrib><creatorcontrib>Wang, Fu-Sheng</creatorcontrib><creatorcontrib>Zhang, Lunli</creatorcontrib><creatorcontrib>Wu, Shanming</creatorcontrib><creatorcontrib>Tang, Hong</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Lin, Feng</creatorcontrib><creatorcontrib>Yang, Yongfeng</creatorcontrib><creatorcontrib>Gong, Guozhong</creatorcontrib><creatorcontrib>Flaherty, John F</creatorcontrib><creatorcontrib>Gaggar, Anuj</creatorcontrib><creatorcontrib>Mo, Shuyuan</creatorcontrib><creatorcontrib>Cheng, Cong</creatorcontrib><creatorcontrib>Camus, Gregory</creatorcontrib><creatorcontrib>Chen, Chengwei</creatorcontrib><creatorcontrib>Huang, Yan</creatorcontrib><creatorcontrib>Jia, Jidong</creatorcontrib><creatorcontrib>Zhang, Mingxiang</creatorcontrib><creatorcontrib>GS-US-320-0110 and GS-US-320-0108 China Investigators</creatorcontrib><title>3-year Treatment of Tenofovir Alafenamide vs . Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China</title><title>Journal of clinical and translational hepatology</title><addtitle>J Clin Transl Hepatol</addtitle><description>Tenofovir alafenamide (TAF) has similar efficacy to tenofovir disoproxil fumarate (TDF) but with improved renal and bone safety in chronic hepatitis B patients studied outside of China. We report 3-year results from two phase 3 studies with TAF in China (Clinicaltrials.gov: NCT02836249 and NCT02836236).
Chinese hepatitis B e antigen (HBeAg)-positive and -negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks (3 years). Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.
Of the 334 patients (180 HBeAg-positive and 154 HBeAg-negative) randomized and treated, baseline characteristics were similar between groups. The overall mean age was 38 years and 73% were male. The mean HBV DNA was 6.4 log
IU/mL. The median alanine aminotransferase was 88 U/L, and 37% had a history of antiviral use. At week 144, the proportion with HBV DNA <29 IU/mL was similar among the two groups, with TAF at 83% vs. TDF at 79%, and TAF at 93% vs. TDF at 92% for the HBeAg-positive and -negative patients, respectively. In each study, higher proportions of TAF than TDF patients showed normalized alanine aminotransferase (via the American Association for the Study of Liver Diseases and the China criteria) and showed loss of HBsAg; meanwhile, the HBeAg seroconversion rates were similar. Treatment was well-tolerated among the TAF patients, who showed a smaller median decline in creatinine clearance (-0.4 vs. -3.2 mL/min;
=0.014) and less percentage change in bone mineral density vs. TDF at hip (-0.95% vs. -1.93%) and spine (+0.35% vs. -1.40%).
In chronic hepatitis B patients from China, TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years.</description><subject>Original</subject><issn>2225-0719</issn><issn>2310-8819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkTtPBCEUhYnRqFF7K0NpMyvPARoTXR-rMbFZbQkzA4qZgRVmN-6_F5_RihvOuYfL_QA4xGiCGcHy5HY6n00IImiCEGZ8A-wSilElJVabpSaEV0hgtQMOcn5BxcMxqhXaBjuUEYIVlrsg0mptTYLzZM042DDC6ODchujiyid41htngxl8Z-Eqw8kf6cLnuEjxzffwajmYZEYLXUxw-pxi8C2cnT_Cm-BsO_oYoA9F8MHsgy1n-mwPvs898HB1OZ_Oqrv765vp2V3VUlWPVddZJRsmTUdVg1VTN7KuRWuQ4J1rMHKssYbUVDLBhRScGcRqTlm5FLjhiu6B06_cxbIZbNeWnyXT60XyZdS1jsbr_0rwz_oprrQkVJRlloDj74AUX5c2j3rwubV9b4KNy6wJZ7JGRHBSrOjL2qaYc7Lu9xmM9Ccq_YFKf6DSn6hKy9Hf8X4bfsDQd5hej3M</recordid><startdate>20210628</startdate><enddate>20210628</enddate><creator>Hou, Jinlin</creator><creator>Ning, Qin</creator><creator>Duan, Zhongping</creator><creator>Chen, You</creator><creator>Xie, Qing</creator><creator>Wang, Fu-Sheng</creator><creator>Zhang, Lunli</creator><creator>Wu, Shanming</creator><creator>Tang, Hong</creator><creator>Li, Jun</creator><creator>Lin, Feng</creator><creator>Yang, Yongfeng</creator><creator>Gong, Guozhong</creator><creator>Flaherty, John F</creator><creator>Gaggar, Anuj</creator><creator>Mo, Shuyuan</creator><creator>Cheng, Cong</creator><creator>Camus, Gregory</creator><creator>Chen, Chengwei</creator><creator>Huang, Yan</creator><creator>Jia, Jidong</creator><creator>Zhang, Mingxiang</creator><general>XIA & HE Publishing Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210628</creationdate><title>3-year Treatment of Tenofovir Alafenamide vs . 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Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China</atitle><jtitle>Journal of clinical and translational hepatology</jtitle><addtitle>J Clin Transl Hepatol</addtitle><date>2021-06-28</date><risdate>2021</risdate><volume>9</volume><issue>3</issue><spage>324</spage><epage>334</epage><pages>324-334</pages><issn>2225-0719</issn><eissn>2310-8819</eissn><abstract>Tenofovir alafenamide (TAF) has similar efficacy to tenofovir disoproxil fumarate (TDF) but with improved renal and bone safety in chronic hepatitis B patients studied outside of China. We report 3-year results from two phase 3 studies with TAF in China (Clinicaltrials.gov: NCT02836249 and NCT02836236).
Chinese hepatitis B e antigen (HBeAg)-positive and -negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks (3 years). Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.
Of the 334 patients (180 HBeAg-positive and 154 HBeAg-negative) randomized and treated, baseline characteristics were similar between groups. The overall mean age was 38 years and 73% were male. The mean HBV DNA was 6.4 log
IU/mL. The median alanine aminotransferase was 88 U/L, and 37% had a history of antiviral use. At week 144, the proportion with HBV DNA <29 IU/mL was similar among the two groups, with TAF at 83% vs. TDF at 79%, and TAF at 93% vs. TDF at 92% for the HBeAg-positive and -negative patients, respectively. In each study, higher proportions of TAF than TDF patients showed normalized alanine aminotransferase (via the American Association for the Study of Liver Diseases and the China criteria) and showed loss of HBsAg; meanwhile, the HBeAg seroconversion rates were similar. Treatment was well-tolerated among the TAF patients, who showed a smaller median decline in creatinine clearance (-0.4 vs. -3.2 mL/min;
=0.014) and less percentage change in bone mineral density vs. TDF at hip (-0.95% vs. -1.93%) and spine (+0.35% vs. -1.40%).
In chronic hepatitis B patients from China, TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years.</abstract><cop>China</cop><pub>XIA & HE Publishing Inc</pub><pmid>34221918</pmid><doi>10.14218/JCTH.2020.00145</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| title | 3-year Treatment of Tenofovir Alafenamide vs . Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China |
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