Neutrophil to Lymphocyte Ratio in Maternal Blood: A Clue to Suspect Amnionitis
There is no information about whether maternal neutrophil to lymphocyte ratios (NLRs) progressively increase with respect to the progression of acute histologic chorioamnionitis (acute-HCA) and increased maternal NLR is a risk factor for amnionitis, known as advanced acute-HCA, in pregnant women at...
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| Veröffentlicht in: | Journal of clinical medicine 2021-06, Vol.10 (12), p.2673 |
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| creator | Lee, Joon-Hyung Park, Chan-Wook Moon, Kyung-Chul Park, Joong-Shin Jun, Jong-Kwan |
| description | There is no information about whether maternal neutrophil to lymphocyte ratios (NLRs) progressively increase with respect to the progression of acute histologic chorioamnionitis (acute-HCA) and increased maternal NLR is a risk factor for amnionitis, known as advanced acute-HCA, in pregnant women at risk for spontaneous preterm birth (PTB). The objective of the current study is to examine this issue. The study population included 132 singleton PTB ( |
| doi_str_mv | 10.3390/jcm10122673 |
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The objective of the current study is to examine this issue. The study population included 132 singleton PTB (<34 weeks) due to either preterm labor or preterm-PROM with both placental pathology and maternal CBC results within 48 h before delivery. We examined maternal NLRs according to the progression of acute-HCA in extra-placental membranes (EPM) (i.e., group-0, inflammation-free EPM; group-1, inflammation restricted to decidua; group-2, inflammation restricted to the membranous trophoblast of chorion and the decidua; group-3, inflammation in the connective tissue of chorion but not amnion; group-4, amnionitis). Maternal NLRs significantly and progressively increased with the progression of acute-HCA (Spearman’s rank correlation test, γ = 0.363, p = 0.000019). Moreover, the increased maternal NLR (≥7.75) (Odds-ratio 5.56, 95% confidence-interval 1.26-24.62, p < 0.05) was a significant independent risk factor for amnionitis even after the correction for potential confounders. In conclusion, maternal NLRs significantly and progressively increased according to the progression of acute-HCA and the increased maternal NLR (≥7.75) was an independent risk factor for amnionitis in spontaneous PTB. The evaluation of the performance of NLR should clearly require a prospective description of this parameter in a cohort of patients with either threatened PTL or preterm-PROM.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10122673</identifier><identifier>PMID: 34204466</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Amniocentesis ; Antibiotics ; Birth weight ; Blood ; Clinical medicine ; Connective tissue ; Infections ; Inflammation ; Lymphocytes ; Medical prognosis ; Neutrophils ; Pregnancy ; Sepsis ; Vagina ; Womens health</subject><ispartof>Journal of clinical medicine, 2021-06, Vol.10 (12), p.2673</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-729a52486ff87a24999fa0e26bf4fd76c8b37d7ff4ac0839dffa77b8842f74233</citedby><cites>FETCH-LOGICAL-c386t-729a52486ff87a24999fa0e26bf4fd76c8b37d7ff4ac0839dffa77b8842f74233</cites><orcidid>0000-0002-1290-6438 ; 0000-0002-5246-0477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235298/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235298/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Lee, Joon-Hyung</creatorcontrib><creatorcontrib>Park, Chan-Wook</creatorcontrib><creatorcontrib>Moon, Kyung-Chul</creatorcontrib><creatorcontrib>Park, Joong-Shin</creatorcontrib><creatorcontrib>Jun, Jong-Kwan</creatorcontrib><title>Neutrophil to Lymphocyte Ratio in Maternal Blood: A Clue to Suspect Amnionitis</title><title>Journal of clinical medicine</title><description>There is no information about whether maternal neutrophil to lymphocyte ratios (NLRs) progressively increase with respect to the progression of acute histologic chorioamnionitis (acute-HCA) and increased maternal NLR is a risk factor for amnionitis, known as advanced acute-HCA, in pregnant women at risk for spontaneous preterm birth (PTB). The objective of the current study is to examine this issue. The study population included 132 singleton PTB (<34 weeks) due to either preterm labor or preterm-PROM with both placental pathology and maternal CBC results within 48 h before delivery. We examined maternal NLRs according to the progression of acute-HCA in extra-placental membranes (EPM) (i.e., group-0, inflammation-free EPM; group-1, inflammation restricted to decidua; group-2, inflammation restricted to the membranous trophoblast of chorion and the decidua; group-3, inflammation in the connective tissue of chorion but not amnion; group-4, amnionitis). Maternal NLRs significantly and progressively increased with the progression of acute-HCA (Spearman’s rank correlation test, γ = 0.363, p = 0.000019). Moreover, the increased maternal NLR (≥7.75) (Odds-ratio 5.56, 95% confidence-interval 1.26-24.62, p < 0.05) was a significant independent risk factor for amnionitis even after the correction for potential confounders. In conclusion, maternal NLRs significantly and progressively increased according to the progression of acute-HCA and the increased maternal NLR (≥7.75) was an independent risk factor for amnionitis in spontaneous PTB. The evaluation of the performance of NLR should clearly require a prospective description of this parameter in a cohort of patients with either threatened PTL or preterm-PROM.</description><subject>Amniocentesis</subject><subject>Antibiotics</subject><subject>Birth weight</subject><subject>Blood</subject><subject>Clinical medicine</subject><subject>Connective tissue</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Neutrophils</subject><subject>Pregnancy</subject><subject>Sepsis</subject><subject>Vagina</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkV1LwzAUhoMoTuau_AMBbwSppknapF4Ic_gFc4If1yFNE5fRNrVJhf17Wzdkem7OgfPwnpfzAnASowtCMnS5UlWMYoxTRvbAEUaMRYhwsr8zj8DE-xXqi3OKY3YIRoRiRGmaHoHFQnehdc3SljA4OF9XzdKpddDwRQbroK3hkwy6rWUJb0rniis4hbOy0wP92vlGqwCnVW1dbYP1x-DAyNLrybaPwfvd7dvsIZo_3z_OpvNIEZ6GiOFMJpjy1BjOJKZZlhmJNE5zQ03BUsVzwgpmDJUKcZIVxkjG8sG_YRQTMgbXG92myytdKF2HVpaiaW0l27Vw0oq_m9ouxYf7EhyTBGe8FzjbCrTus9M-iMp6pctS1tp1XuCE9nfThOAePf2Hrlw3POSH6r0zwlFPnW8o1TrvW21-zcRIDFGJnajIN09bhKI</recordid><startdate>20210617</startdate><enddate>20210617</enddate><creator>Lee, Joon-Hyung</creator><creator>Park, Chan-Wook</creator><creator>Moon, Kyung-Chul</creator><creator>Park, Joong-Shin</creator><creator>Jun, Jong-Kwan</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1290-6438</orcidid><orcidid>https://orcid.org/0000-0002-5246-0477</orcidid></search><sort><creationdate>20210617</creationdate><title>Neutrophil to Lymphocyte Ratio in Maternal Blood: A Clue to Suspect Amnionitis</title><author>Lee, Joon-Hyung ; Park, Chan-Wook ; Moon, Kyung-Chul ; Park, Joong-Shin ; Jun, Jong-Kwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-729a52486ff87a24999fa0e26bf4fd76c8b37d7ff4ac0839dffa77b8842f74233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amniocentesis</topic><topic>Antibiotics</topic><topic>Birth weight</topic><topic>Blood</topic><topic>Clinical medicine</topic><topic>Connective tissue</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Neutrophils</topic><topic>Pregnancy</topic><topic>Sepsis</topic><topic>Vagina</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Joon-Hyung</creatorcontrib><creatorcontrib>Park, Chan-Wook</creatorcontrib><creatorcontrib>Moon, Kyung-Chul</creatorcontrib><creatorcontrib>Park, Joong-Shin</creatorcontrib><creatorcontrib>Jun, Jong-Kwan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Joon-Hyung</au><au>Park, Chan-Wook</au><au>Moon, Kyung-Chul</au><au>Park, Joong-Shin</au><au>Jun, Jong-Kwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil to Lymphocyte Ratio in Maternal Blood: A Clue to Suspect Amnionitis</atitle><jtitle>Journal of clinical medicine</jtitle><date>2021-06-17</date><risdate>2021</risdate><volume>10</volume><issue>12</issue><spage>2673</spage><pages>2673-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>There is no information about whether maternal neutrophil to lymphocyte ratios (NLRs) progressively increase with respect to the progression of acute histologic chorioamnionitis (acute-HCA) and increased maternal NLR is a risk factor for amnionitis, known as advanced acute-HCA, in pregnant women at risk for spontaneous preterm birth (PTB). The objective of the current study is to examine this issue. The study population included 132 singleton PTB (<34 weeks) due to either preterm labor or preterm-PROM with both placental pathology and maternal CBC results within 48 h before delivery. We examined maternal NLRs according to the progression of acute-HCA in extra-placental membranes (EPM) (i.e., group-0, inflammation-free EPM; group-1, inflammation restricted to decidua; group-2, inflammation restricted to the membranous trophoblast of chorion and the decidua; group-3, inflammation in the connective tissue of chorion but not amnion; group-4, amnionitis). Maternal NLRs significantly and progressively increased with the progression of acute-HCA (Spearman’s rank correlation test, γ = 0.363, p = 0.000019). Moreover, the increased maternal NLR (≥7.75) (Odds-ratio 5.56, 95% confidence-interval 1.26-24.62, p < 0.05) was a significant independent risk factor for amnionitis even after the correction for potential confounders. In conclusion, maternal NLRs significantly and progressively increased according to the progression of acute-HCA and the increased maternal NLR (≥7.75) was an independent risk factor for amnionitis in spontaneous PTB. The evaluation of the performance of NLR should clearly require a prospective description of this parameter in a cohort of patients with either threatened PTL or preterm-PROM.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34204466</pmid><doi>10.3390/jcm10122673</doi><orcidid>https://orcid.org/0000-0002-1290-6438</orcidid><orcidid>https://orcid.org/0000-0002-5246-0477</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Amniocentesis Antibiotics Birth weight Blood Clinical medicine Connective tissue Infections Inflammation Lymphocytes Medical prognosis Neutrophils Pregnancy Sepsis Vagina Womens health |
| title | Neutrophil to Lymphocyte Ratio in Maternal Blood: A Clue to Suspect Amnionitis |
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