Role of hepatosteatosis in the prognosis of COVID 19 disease
To measure the degree of fatty liver using non-contrast enhanced chest computed tomography (CT) and investigate its relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19) in adult patients. This retrospective study included consecutive patients who had been diagnosed wit...
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| Veröffentlicht in: | Clinical imaging 2021-12, Vol.80, p.1-5 |
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| creator | Çoraplı, Mahmut Çil, Ercan Oktay, Cemil Kaçmaz, Hüseyin Çoraplı, Gökhan Bulut, Hacı Taner |
| description | To measure the degree of fatty liver using non-contrast enhanced chest computed tomography (CT) and investigate its relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19) in adult patients.
This retrospective study included consecutive patients who had been diagnosed with COVID-19 using real-time reverse-transcription polymerase chain reaction (RT-PCR) and subsequently underwent non-contrast enhanced chest CT between October 10 and December 10, 2020. Hepatic attenuation values were measured from Couinaud segments 2, 4, and 8 based on the CT images and the relationships between these values and the Pneumonia Severity Score (PSS), requirement of hospitalization, and the length of hospital and intensive care unit (ICU) stay were analyzed.
The study included 414 patients (182 were female, 43.96%), among whom 106 (25.6%) were diagnosed with hepatosteatosis (HS). In the patients with HS, the PSS scores were higher (10.8 ± 4.96 vs. 8.07 ± 5.12; p |
| doi_str_mv | 10.1016/j.clinimag.2021.06.034 |
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This retrospective study included consecutive patients who had been diagnosed with COVID-19 using real-time reverse-transcription polymerase chain reaction (RT-PCR) and subsequently underwent non-contrast enhanced chest CT between October 10 and December 10, 2020. Hepatic attenuation values were measured from Couinaud segments 2, 4, and 8 based on the CT images and the relationships between these values and the Pneumonia Severity Score (PSS), requirement of hospitalization, and the length of hospital and intensive care unit (ICU) stay were analyzed.
The study included 414 patients (182 were female, 43.96%), among whom 106 (25.6%) were diagnosed with hepatosteatosis (HS). In the patients with HS, the PSS scores were higher (10.8 ± 4.96 vs. 8.07 ± 5.12; p < 0.001), and 69 (65%) received inpatient care. Moreover, the number of HS patients who received inpatient care was 1.99 (95% confidence interval (CI) 1.26–3.15, p < 0.003) times higher than that of the non-HS patients. No significant difference was found between the HS and non-HS patients with regard to the length of hospital or ICU stay.
HS can be easily evaluated using non-contrast enhanced chest CT in COVID-19 patients and can be used as a prognostic marker to determine the requirement of hospitalization.
•Hepatosteatosis can be used as a prognostic marker to determine the requirement of hospitalization in COVID-19.•There are significant differences between patients with and without hepatosteatosis in terms of inpatient treatment.•There is a significant relationship between hepatosteatosis and high pneumonia severity score.•Hepatosteatosis can be easily evaluated using non-contrast enhanced chest CT in COVID-19 patients.</description><identifier>ISSN: 0899-7071</identifier><identifier>EISSN: 1873-4499</identifier><identifier>DOI: 10.1016/j.clinimag.2021.06.034</identifier><identifier>PMID: 34214871</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age ; Attenuation ; Cardiothoracic Imaging ; Chest ; Computed tomography ; Confidence intervals ; Coronaviruses ; COVID-19 ; Fatty liver ; Female ; Hepatectomy ; Hepatosteatosis ; Hounsfield unit ; Humans ; Liver ; Metabolism ; Mortality ; Patients ; Pneumonia ; Polymerase chain reaction ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Tomography, X-Ray Computed ; Viral diseases</subject><ispartof>Clinical imaging, 2021-12, Vol.80, p.1-5</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Dec 2021</rights><rights>2021 Elsevier Inc. All rights reserved. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-bd85546bb99ca79aabeb7a5606edfd379700d47b87d25640741066499c9957013</citedby><cites>FETCH-LOGICAL-c499t-bd85546bb99ca79aabeb7a5606edfd379700d47b87d25640741066499c9957013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0899707121002801$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34214871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çoraplı, Mahmut</creatorcontrib><creatorcontrib>Çil, Ercan</creatorcontrib><creatorcontrib>Oktay, Cemil</creatorcontrib><creatorcontrib>Kaçmaz, Hüseyin</creatorcontrib><creatorcontrib>Çoraplı, Gökhan</creatorcontrib><creatorcontrib>Bulut, Hacı Taner</creatorcontrib><title>Role of hepatosteatosis in the prognosis of COVID 19 disease</title><title>Clinical imaging</title><addtitle>Clin Imaging</addtitle><description>To measure the degree of fatty liver using non-contrast enhanced chest computed tomography (CT) and investigate its relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19) in adult patients.
This retrospective study included consecutive patients who had been diagnosed with COVID-19 using real-time reverse-transcription polymerase chain reaction (RT-PCR) and subsequently underwent non-contrast enhanced chest CT between October 10 and December 10, 2020. Hepatic attenuation values were measured from Couinaud segments 2, 4, and 8 based on the CT images and the relationships between these values and the Pneumonia Severity Score (PSS), requirement of hospitalization, and the length of hospital and intensive care unit (ICU) stay were analyzed.
The study included 414 patients (182 were female, 43.96%), among whom 106 (25.6%) were diagnosed with hepatosteatosis (HS). In the patients with HS, the PSS scores were higher (10.8 ± 4.96 vs. 8.07 ± 5.12; p < 0.001), and 69 (65%) received inpatient care. Moreover, the number of HS patients who received inpatient care was 1.99 (95% confidence interval (CI) 1.26–3.15, p < 0.003) times higher than that of the non-HS patients. No significant difference was found between the HS and non-HS patients with regard to the length of hospital or ICU stay.
HS can be easily evaluated using non-contrast enhanced chest CT in COVID-19 patients and can be used as a prognostic marker to determine the requirement of hospitalization.
•Hepatosteatosis can be used as a prognostic marker to determine the requirement of hospitalization in COVID-19.•There are significant differences between patients with and without hepatosteatosis in terms of inpatient treatment.•There is a significant relationship between hepatosteatosis and high pneumonia severity score.•Hepatosteatosis can be easily evaluated using non-contrast enhanced chest CT in COVID-19 patients.</description><subject>Adult</subject><subject>Age</subject><subject>Attenuation</subject><subject>Cardiothoracic Imaging</subject><subject>Chest</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Fatty liver</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Hepatosteatosis</subject><subject>Hounsfield unit</subject><subject>Humans</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Tomography, X-Ray Computed</subject><subject>Viral diseases</subject><issn>0899-7071</issn><issn>1873-4499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtLAzEQhYMoWi9_QRZ88WXXZDebC4go9QqCIOpryCbTNmW7qcm24L83tSrqiy8JZL4zMycHoUOCC4IJO5kWpnWdm-lxUeKSFJgVuKIbaEAEr3JKpdxEAyykzDnmZAftxjjFSSgp30Y7FS0JFZwM0OmjbyHzo2wCc9372MPqdDFzXdZPIJsHP-4-HhIzfHi5u8yIzKyLoCPso62RbiMcfN576Pn66ml4m98_3NwNL-5zk_bo88aKuqasaaQ0mkutG2i4rhlmYEe24pJjbClvBLdlzSjmlGDGktRIWXNMqj10tu47XzQzsAa6PuhWzUPyH96U1079rnRuosZ-qUSZnFKRGhx_Ngj-dQGxVzMXDbSt7sAvoirrBEnJ5WrW0R906hehS_YSJZjkvBZVotiaMsHHGGD0vQzBahWQmqqvgNQqIIWZSgEl4eFPK9-yr0QScL4GIH3o0kFQ0TjoDFgXwPTKevffjHf34qOK</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Çoraplı, Mahmut</creator><creator>Çil, Ercan</creator><creator>Oktay, Cemil</creator><creator>Kaçmaz, Hüseyin</creator><creator>Çoraplı, Gökhan</creator><creator>Bulut, Hacı Taner</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211201</creationdate><title>Role of hepatosteatosis in the prognosis of COVID 19 disease</title><author>Çoraplı, Mahmut ; Çil, Ercan ; Oktay, Cemil ; Kaçmaz, Hüseyin ; Çoraplı, Gökhan ; Bulut, Hacı Taner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-bd85546bb99ca79aabeb7a5606edfd379700d47b87d25640741066499c9957013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Age</topic><topic>Attenuation</topic><topic>Cardiothoracic Imaging</topic><topic>Chest</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Fatty liver</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>Hepatosteatosis</topic><topic>Hounsfield unit</topic><topic>Humans</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Polymerase chain reaction</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Tomography, X-Ray Computed</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çoraplı, Mahmut</creatorcontrib><creatorcontrib>Çil, Ercan</creatorcontrib><creatorcontrib>Oktay, Cemil</creatorcontrib><creatorcontrib>Kaçmaz, Hüseyin</creatorcontrib><creatorcontrib>Çoraplı, Gökhan</creatorcontrib><creatorcontrib>Bulut, Hacı Taner</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çoraplı, Mahmut</au><au>Çil, Ercan</au><au>Oktay, Cemil</au><au>Kaçmaz, Hüseyin</au><au>Çoraplı, Gökhan</au><au>Bulut, Hacı Taner</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of hepatosteatosis in the prognosis of COVID 19 disease</atitle><jtitle>Clinical imaging</jtitle><addtitle>Clin Imaging</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>80</volume><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0899-7071</issn><eissn>1873-4499</eissn><abstract>To measure the degree of fatty liver using non-contrast enhanced chest computed tomography (CT) and investigate its relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19) in adult patients.
This retrospective study included consecutive patients who had been diagnosed with COVID-19 using real-time reverse-transcription polymerase chain reaction (RT-PCR) and subsequently underwent non-contrast enhanced chest CT between October 10 and December 10, 2020. Hepatic attenuation values were measured from Couinaud segments 2, 4, and 8 based on the CT images and the relationships between these values and the Pneumonia Severity Score (PSS), requirement of hospitalization, and the length of hospital and intensive care unit (ICU) stay were analyzed.
The study included 414 patients (182 were female, 43.96%), among whom 106 (25.6%) were diagnosed with hepatosteatosis (HS). In the patients with HS, the PSS scores were higher (10.8 ± 4.96 vs. 8.07 ± 5.12; p < 0.001), and 69 (65%) received inpatient care. Moreover, the number of HS patients who received inpatient care was 1.99 (95% confidence interval (CI) 1.26–3.15, p < 0.003) times higher than that of the non-HS patients. No significant difference was found between the HS and non-HS patients with regard to the length of hospital or ICU stay.
HS can be easily evaluated using non-contrast enhanced chest CT in COVID-19 patients and can be used as a prognostic marker to determine the requirement of hospitalization.
•Hepatosteatosis can be used as a prognostic marker to determine the requirement of hospitalization in COVID-19.•There are significant differences between patients with and without hepatosteatosis in terms of inpatient treatment.•There is a significant relationship between hepatosteatosis and high pneumonia severity score.•Hepatosteatosis can be easily evaluated using non-contrast enhanced chest CT in COVID-19 patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34214871</pmid><doi>10.1016/j.clinimag.2021.06.034</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Age Attenuation Cardiothoracic Imaging Chest Computed tomography Confidence intervals Coronaviruses COVID-19 Fatty liver Female Hepatectomy Hepatosteatosis Hounsfield unit Humans Liver Metabolism Mortality Patients Pneumonia Polymerase chain reaction Prognosis Retrospective Studies SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Tomography, X-Ray Computed Viral diseases |
| title | Role of hepatosteatosis in the prognosis of COVID 19 disease |
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