Differentiation of Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Related Interstitial Lung Disease Using Quantitative Imaging

A usual interstitial pneumonia (UIP) imaging pattern can be seen in both idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD). The purpose of this multicenter study was to assess whether quantitative imaging data differ between IPF and CTD-ILD...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of clinical medicine 2021-06, Vol.10 (12), p.2663
Hauptverfasser: Chung, Jonathan H., Adegunsoye, Ayodeji, Cannon, Brenna, Vij, Rekha, Oldham, Justin M., King, Christopher, Montner, Steven M., Thirkateh, Prahasit, Barnett, Scott, Karwoski, Ronald, Bartholmai, Brian J., Strek, Mary, Nathan, Steven D.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 12
container_start_page 2663
container_title Journal of clinical medicine
container_volume 10
creator Chung, Jonathan H.
Adegunsoye, Ayodeji
Cannon, Brenna
Vij, Rekha
Oldham, Justin M.
King, Christopher
Montner, Steven M.
Thirkateh, Prahasit
Barnett, Scott
Karwoski, Ronald
Bartholmai, Brian J.
Strek, Mary
Nathan, Steven D.
description A usual interstitial pneumonia (UIP) imaging pattern can be seen in both idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD). The purpose of this multicenter study was to assess whether quantitative imaging data differ between IPF and CTD-ILD in the setting of UIP. Patients evaluated at two medical centers with CTD-ILD or IPF and a UIP pattern on CT or pathology served as derivation and validation cohorts. Chest CT data were quantitatively analyzed including total volumes of honeycombing, reticulation, ground-glass opacity, normal lung, and vessel related structures (VRS). VRS was compared with forced vital capacity percent predicted (FVC%) and percent predicted diffusing capacity of the lungs for carbon monoxide (DLCO%). There were 296 subjects in total, with 40 CTD-ILD and 85 IPF subjects in the derivation cohort, and 62 CTD-ILD and 109 IPF subjects in the validation cohort. VRS was greater in IPF across the cohorts on univariate (p < 0.001) and multivariable (p < 0.001–0.047) analyses. VRS was inversely correlated with DLCO% in both cohorts on univariate (p < 0.001) and in the derivation cohort on multivariable analysis (p = 0.003) but not FVC%. Total volume of normal lung was associated with DLCO% (p < 0.001) and FVC% (p < 0.001–0.009) on multivariable analysis in both cohorts. VRS appears to have promise in differentiating CTD-ILD from IPF. The underlying pathophysiological relationship between VRS and ILD is complex and is likely not explained solely by lung fibrosis.
doi_str_mv 10.3390/jcm10122663
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8233999</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2545002500</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-b34b94888d037e4c13a1d7d4682541628132d18741d0b7832ff0c3605c25248c3</originalsourceid><addsrcrecordid>eNpdkdtKxDAQhoMoKqtXvkDAG0GqOW2bvRFkPS0seECvQ5pO1yxtsiap4Dv40MYjamBIJvn4M_8MQnuUHHE-IcdL01NCGStLvoa2GamqgnDJ13-dt9BujEuSl5SC0WoTbXHBiKBSbKPXM9u2EMAlq5P1DvsWzxrrVzo9WoNvhq73TocXfGHr4KONuA2-x1PvHJhknwHf2xgHwGc2go5Q3EGnEzR45hKEmGzW7fB8cItvAj9Em7PbQec_k_7QmPV6kS930Earuwi7X_sIPVyc30-vivn15Wx6Oi8Ml2Uqai7qiZBSNoRXIAzlmjZVI0rJxoKWTFLOGiorQRtSV5KztiWGl2Rs2JgJafgInXzqroa6h8Zk90F3ahVsn60qr636--Lso1r4ZyVZbvpkkgUOvgSCfxogJtXbaKDrtAM_RJXrkIJQmvER2v-HLv0QXLb3To0JYTkydfhJmdzkGKD9KYYS9T5o9WvQ_A2Q6Zsv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545002500</pqid></control><display><type>article</type><title>Differentiation of Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Related Interstitial Lung Disease Using Quantitative Imaging</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Chung, Jonathan H. ; Adegunsoye, Ayodeji ; Cannon, Brenna ; Vij, Rekha ; Oldham, Justin M. ; King, Christopher ; Montner, Steven M. ; Thirkateh, Prahasit ; Barnett, Scott ; Karwoski, Ronald ; Bartholmai, Brian J. ; Strek, Mary ; Nathan, Steven D.</creator><creatorcontrib>Chung, Jonathan H. ; Adegunsoye, Ayodeji ; Cannon, Brenna ; Vij, Rekha ; Oldham, Justin M. ; King, Christopher ; Montner, Steven M. ; Thirkateh, Prahasit ; Barnett, Scott ; Karwoski, Ronald ; Bartholmai, Brian J. ; Strek, Mary ; Nathan, Steven D.</creatorcontrib><description>A usual interstitial pneumonia (UIP) imaging pattern can be seen in both idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD). The purpose of this multicenter study was to assess whether quantitative imaging data differ between IPF and CTD-ILD in the setting of UIP. Patients evaluated at two medical centers with CTD-ILD or IPF and a UIP pattern on CT or pathology served as derivation and validation cohorts. Chest CT data were quantitatively analyzed including total volumes of honeycombing, reticulation, ground-glass opacity, normal lung, and vessel related structures (VRS). VRS was compared with forced vital capacity percent predicted (FVC%) and percent predicted diffusing capacity of the lungs for carbon monoxide (DLCO%). There were 296 subjects in total, with 40 CTD-ILD and 85 IPF subjects in the derivation cohort, and 62 CTD-ILD and 109 IPF subjects in the validation cohort. VRS was greater in IPF across the cohorts on univariate (p &lt; 0.001) and multivariable (p &lt; 0.001–0.047) analyses. VRS was inversely correlated with DLCO% in both cohorts on univariate (p &lt; 0.001) and in the derivation cohort on multivariable analysis (p = 0.003) but not FVC%. Total volume of normal lung was associated with DLCO% (p &lt; 0.001) and FVC% (p &lt; 0.001–0.009) on multivariable analysis in both cohorts. VRS appears to have promise in differentiating CTD-ILD from IPF. The underlying pathophysiological relationship between VRS and ILD is complex and is likely not explained solely by lung fibrosis.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10122663</identifier><identifier>PMID: 34204184</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Automation ; Clinical medicine ; Clinical outcomes ; Connective tissue diseases ; Lung diseases ; Medical imaging ; Medical prognosis ; Patients ; Pulmonary fibrosis ; Rheumatoid arthritis ; Software</subject><ispartof>Journal of clinical medicine, 2021-06, Vol.10 (12), p.2663</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-b34b94888d037e4c13a1d7d4682541628132d18741d0b7832ff0c3605c25248c3</citedby><cites>FETCH-LOGICAL-c386t-b34b94888d037e4c13a1d7d4682541628132d18741d0b7832ff0c3605c25248c3</cites><orcidid>0000-0002-7671-1023 ; 0000-0001-7834-6579</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233999/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233999/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Chung, Jonathan H.</creatorcontrib><creatorcontrib>Adegunsoye, Ayodeji</creatorcontrib><creatorcontrib>Cannon, Brenna</creatorcontrib><creatorcontrib>Vij, Rekha</creatorcontrib><creatorcontrib>Oldham, Justin M.</creatorcontrib><creatorcontrib>King, Christopher</creatorcontrib><creatorcontrib>Montner, Steven M.</creatorcontrib><creatorcontrib>Thirkateh, Prahasit</creatorcontrib><creatorcontrib>Barnett, Scott</creatorcontrib><creatorcontrib>Karwoski, Ronald</creatorcontrib><creatorcontrib>Bartholmai, Brian J.</creatorcontrib><creatorcontrib>Strek, Mary</creatorcontrib><creatorcontrib>Nathan, Steven D.</creatorcontrib><title>Differentiation of Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Related Interstitial Lung Disease Using Quantitative Imaging</title><title>Journal of clinical medicine</title><description>A usual interstitial pneumonia (UIP) imaging pattern can be seen in both idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD). The purpose of this multicenter study was to assess whether quantitative imaging data differ between IPF and CTD-ILD in the setting of UIP. Patients evaluated at two medical centers with CTD-ILD or IPF and a UIP pattern on CT or pathology served as derivation and validation cohorts. Chest CT data were quantitatively analyzed including total volumes of honeycombing, reticulation, ground-glass opacity, normal lung, and vessel related structures (VRS). VRS was compared with forced vital capacity percent predicted (FVC%) and percent predicted diffusing capacity of the lungs for carbon monoxide (DLCO%). There were 296 subjects in total, with 40 CTD-ILD and 85 IPF subjects in the derivation cohort, and 62 CTD-ILD and 109 IPF subjects in the validation cohort. VRS was greater in IPF across the cohorts on univariate (p &lt; 0.001) and multivariable (p &lt; 0.001–0.047) analyses. VRS was inversely correlated with DLCO% in both cohorts on univariate (p &lt; 0.001) and in the derivation cohort on multivariable analysis (p = 0.003) but not FVC%. Total volume of normal lung was associated with DLCO% (p &lt; 0.001) and FVC% (p &lt; 0.001–0.009) on multivariable analysis in both cohorts. VRS appears to have promise in differentiating CTD-ILD from IPF. The underlying pathophysiological relationship between VRS and ILD is complex and is likely not explained solely by lung fibrosis.</description><subject>Automation</subject><subject>Clinical medicine</subject><subject>Clinical outcomes</subject><subject>Connective tissue diseases</subject><subject>Lung diseases</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Patients</subject><subject>Pulmonary fibrosis</subject><subject>Rheumatoid arthritis</subject><subject>Software</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkdtKxDAQhoMoKqtXvkDAG0GqOW2bvRFkPS0seECvQ5pO1yxtsiap4Dv40MYjamBIJvn4M_8MQnuUHHE-IcdL01NCGStLvoa2GamqgnDJ13-dt9BujEuSl5SC0WoTbXHBiKBSbKPXM9u2EMAlq5P1DvsWzxrrVzo9WoNvhq73TocXfGHr4KONuA2-x1PvHJhknwHf2xgHwGc2go5Q3EGnEzR45hKEmGzW7fB8cItvAj9Em7PbQec_k_7QmPV6kS930Earuwi7X_sIPVyc30-vivn15Wx6Oi8Ml2Uqai7qiZBSNoRXIAzlmjZVI0rJxoKWTFLOGiorQRtSV5KztiWGl2Rs2JgJafgInXzqroa6h8Zk90F3ahVsn60qr636--Lso1r4ZyVZbvpkkgUOvgSCfxogJtXbaKDrtAM_RJXrkIJQmvER2v-HLv0QXLb3To0JYTkydfhJmdzkGKD9KYYS9T5o9WvQ_A2Q6Zsv</recordid><startdate>20210617</startdate><enddate>20210617</enddate><creator>Chung, Jonathan H.</creator><creator>Adegunsoye, Ayodeji</creator><creator>Cannon, Brenna</creator><creator>Vij, Rekha</creator><creator>Oldham, Justin M.</creator><creator>King, Christopher</creator><creator>Montner, Steven M.</creator><creator>Thirkateh, Prahasit</creator><creator>Barnett, Scott</creator><creator>Karwoski, Ronald</creator><creator>Bartholmai, Brian J.</creator><creator>Strek, Mary</creator><creator>Nathan, Steven D.</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7671-1023</orcidid><orcidid>https://orcid.org/0000-0001-7834-6579</orcidid></search><sort><creationdate>20210617</creationdate><title>Differentiation of Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Related Interstitial Lung Disease Using Quantitative Imaging</title><author>Chung, Jonathan H. ; Adegunsoye, Ayodeji ; Cannon, Brenna ; Vij, Rekha ; Oldham, Justin M. ; King, Christopher ; Montner, Steven M. ; Thirkateh, Prahasit ; Barnett, Scott ; Karwoski, Ronald ; Bartholmai, Brian J. ; Strek, Mary ; Nathan, Steven D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-b34b94888d037e4c13a1d7d4682541628132d18741d0b7832ff0c3605c25248c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Automation</topic><topic>Clinical medicine</topic><topic>Clinical outcomes</topic><topic>Connective tissue diseases</topic><topic>Lung diseases</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Patients</topic><topic>Pulmonary fibrosis</topic><topic>Rheumatoid arthritis</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Jonathan H.</creatorcontrib><creatorcontrib>Adegunsoye, Ayodeji</creatorcontrib><creatorcontrib>Cannon, Brenna</creatorcontrib><creatorcontrib>Vij, Rekha</creatorcontrib><creatorcontrib>Oldham, Justin M.</creatorcontrib><creatorcontrib>King, Christopher</creatorcontrib><creatorcontrib>Montner, Steven M.</creatorcontrib><creatorcontrib>Thirkateh, Prahasit</creatorcontrib><creatorcontrib>Barnett, Scott</creatorcontrib><creatorcontrib>Karwoski, Ronald</creatorcontrib><creatorcontrib>Bartholmai, Brian J.</creatorcontrib><creatorcontrib>Strek, Mary</creatorcontrib><creatorcontrib>Nathan, Steven D.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Jonathan H.</au><au>Adegunsoye, Ayodeji</au><au>Cannon, Brenna</au><au>Vij, Rekha</au><au>Oldham, Justin M.</au><au>King, Christopher</au><au>Montner, Steven M.</au><au>Thirkateh, Prahasit</au><au>Barnett, Scott</au><au>Karwoski, Ronald</au><au>Bartholmai, Brian J.</au><au>Strek, Mary</au><au>Nathan, Steven D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiation of Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Related Interstitial Lung Disease Using Quantitative Imaging</atitle><jtitle>Journal of clinical medicine</jtitle><date>2021-06-17</date><risdate>2021</risdate><volume>10</volume><issue>12</issue><spage>2663</spage><pages>2663-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>A usual interstitial pneumonia (UIP) imaging pattern can be seen in both idiopathic pulmonary fibrosis (IPF) and connective tissue disease-related interstitial lung disease (CTD-ILD). The purpose of this multicenter study was to assess whether quantitative imaging data differ between IPF and CTD-ILD in the setting of UIP. Patients evaluated at two medical centers with CTD-ILD or IPF and a UIP pattern on CT or pathology served as derivation and validation cohorts. Chest CT data were quantitatively analyzed including total volumes of honeycombing, reticulation, ground-glass opacity, normal lung, and vessel related structures (VRS). VRS was compared with forced vital capacity percent predicted (FVC%) and percent predicted diffusing capacity of the lungs for carbon monoxide (DLCO%). There were 296 subjects in total, with 40 CTD-ILD and 85 IPF subjects in the derivation cohort, and 62 CTD-ILD and 109 IPF subjects in the validation cohort. VRS was greater in IPF across the cohorts on univariate (p &lt; 0.001) and multivariable (p &lt; 0.001–0.047) analyses. VRS was inversely correlated with DLCO% in both cohorts on univariate (p &lt; 0.001) and in the derivation cohort on multivariable analysis (p = 0.003) but not FVC%. Total volume of normal lung was associated with DLCO% (p &lt; 0.001) and FVC% (p &lt; 0.001–0.009) on multivariable analysis in both cohorts. VRS appears to have promise in differentiating CTD-ILD from IPF. The underlying pathophysiological relationship between VRS and ILD is complex and is likely not explained solely by lung fibrosis.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34204184</pmid><doi>10.3390/jcm10122663</doi><orcidid>https://orcid.org/0000-0002-7671-1023</orcidid><orcidid>https://orcid.org/0000-0001-7834-6579</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2077-0383
ispartof Journal of clinical medicine, 2021-06, Vol.10 (12), p.2663
issn 2077-0383
2077-0383
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8233999
source PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Automation
Clinical medicine
Clinical outcomes
Connective tissue diseases
Lung diseases
Medical imaging
Medical prognosis
Patients
Pulmonary fibrosis
Rheumatoid arthritis
Software
title Differentiation of Idiopathic Pulmonary Fibrosis from Connective Tissue Disease-Related Interstitial Lung Disease Using Quantitative Imaging
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T10%3A24%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differentiation%20of%20Idiopathic%20Pulmonary%20Fibrosis%20from%20Connective%20Tissue%20Disease-Related%20Interstitial%20Lung%20Disease%20Using%20Quantitative%20Imaging&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Chung,%20Jonathan%20H.&rft.date=2021-06-17&rft.volume=10&rft.issue=12&rft.spage=2663&rft.pages=2663-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm10122663&rft_dat=%3Cproquest_pubme%3E2545002500%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2545002500&rft_id=info:pmid/34204184&rfr_iscdi=true