The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of the leading causes of cancer-related death worldwide. Despite the improvements in surveillance and treatment, the prognosis of HCC remains poor. Extracellular vesicles (EVs) are a heterogeneous group of phospholipi...
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| Veröffentlicht in: | Cancers 2021-06, Vol.13 (12), p.3076 |
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| creator | Lee, Yi-Te Tran, Benjamin V Wang, Jasmine J Liang, Icy Y You, Sungyong Zhu, Yazhen Agopian, Vatche G Tseng, Hsian-Rong Yang, Ju Dong |
| description | Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of the leading causes of cancer-related death worldwide. Despite the improvements in surveillance and treatment, the prognosis of HCC remains poor. Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles circulating in the bloodstream and mediating intercellular communication. Emerging studies have shown that EVs play a crucial role in regulating the proliferation, immune escape, and metastasis of HCC. In addition, because EVs are present in the circulation at relatively early stages of disease, they are getting attention as an attractive biomarker for HCC detection. Over the past decade, dedicated efforts have been made to isolate EVs more efficiently and make them useful tools in different clinical settings. In this review article, we provide an overview of the EVs isolation methods and highlight the role of EVs as mediators in the pathogenesis and progression of HCC. Lastly, we summarize the potential applications of EVs in early-stage HCC detection. |
| doi_str_mv | 10.3390/cancers13123076 |
| format | Article |
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Despite the improvements in surveillance and treatment, the prognosis of HCC remains poor. Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles circulating in the bloodstream and mediating intercellular communication. Emerging studies have shown that EVs play a crucial role in regulating the proliferation, immune escape, and metastasis of HCC. In addition, because EVs are present in the circulation at relatively early stages of disease, they are getting attention as an attractive biomarker for HCC detection. Over the past decade, dedicated efforts have been made to isolate EVs more efficiently and make them useful tools in different clinical settings. In this review article, we provide an overview of the EVs isolation methods and highlight the role of EVs as mediators in the pathogenesis and progression of HCC. Lastly, we summarize the potential applications of EVs in early-stage HCC detection.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13123076</identifier><identifier>PMID: 34203086</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibodies ; Biomarkers ; Biosynthesis ; Cell interactions ; Cell signaling ; Chromatography ; Extracellular vesicles ; Hepatitis ; Hepatocellular carcinoma ; Lipids ; Liver cancer ; Liver diseases ; Malignancy ; Metastases ; Metastasis ; Methods ; Pathogenesis ; Phospholipids ; Polyethylene glycol ; Polymers ; Proteins ; Review</subject><ispartof>Cancers, 2021-06, Vol.13 (12), p.3076</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-1d54113167994dda2c0d04272aa886c128a266c00b4c4f9964143d6ea69052c93</citedby><cites>FETCH-LOGICAL-c421t-1d54113167994dda2c0d04272aa886c128a266c00b4c4f9964143d6ea69052c93</cites><orcidid>0000-0002-5089-1345 ; 0000-0003-3513-1783</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233859/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233859/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34203086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yi-Te</creatorcontrib><creatorcontrib>Tran, Benjamin V</creatorcontrib><creatorcontrib>Wang, Jasmine J</creatorcontrib><creatorcontrib>Liang, Icy Y</creatorcontrib><creatorcontrib>You, Sungyong</creatorcontrib><creatorcontrib>Zhu, Yazhen</creatorcontrib><creatorcontrib>Agopian, Vatche G</creatorcontrib><creatorcontrib>Tseng, Hsian-Rong</creatorcontrib><creatorcontrib>Yang, Ju Dong</creatorcontrib><title>The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of the leading causes of cancer-related death worldwide. 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Lastly, we summarize the potential applications of EVs in early-stage HCC detection.</description><subject>Antibodies</subject><subject>Biomarkers</subject><subject>Biosynthesis</subject><subject>Cell interactions</subject><subject>Cell signaling</subject><subject>Chromatography</subject><subject>Extracellular vesicles</subject><subject>Hepatitis</subject><subject>Hepatocellular carcinoma</subject><subject>Lipids</subject><subject>Liver cancer</subject><subject>Liver diseases</subject><subject>Malignancy</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Pathogenesis</subject><subject>Phospholipids</subject><subject>Polyethylene glycol</subject><subject>Polymers</subject><subject>Proteins</subject><subject>Review</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtLxDAUhYMoKuranQTcuBknr6bNRpAZXyAoom7DNb2jkU4yJq3ov7dFHXSySUK-c24Oh5B9zo6lNGzsIDhMmUsuJCv1GtkWrBQjrY1a_3PeIns5v7J-SclLXW6SLakEk6zS28TdvyC9iw3SOKNnH20Ch03TNZDoI2bvGszUBzr1GSEjvU3xOWHOPgYKoaZTbNG1w62XX-IC2rjUTyA5H-IcdsnGDJqMez_7Dnk4P7ufXI6uby6uJqfXI6cEb0e8LhTvw-jSGFXXIByrmRKlAKgq7bioQGjtGHtSTs2M0YorWWsEbVghnJE75OTbd9E9zbF2GPo4jV0kP4f0aSN4-_8l-Bf7HN9tJaSsisHg6McgxbcOc2vnPg95IGDsshWFqvqhhRA9eriCvsYuhT7eQClTGM0Gw_E35VLMOeFs-RnO7NChXemwVxz8zbDkfxuTX9PVmKc</recordid><startdate>20210620</startdate><enddate>20210620</enddate><creator>Lee, Yi-Te</creator><creator>Tran, Benjamin V</creator><creator>Wang, Jasmine J</creator><creator>Liang, Icy Y</creator><creator>You, Sungyong</creator><creator>Zhu, Yazhen</creator><creator>Agopian, Vatche G</creator><creator>Tseng, Hsian-Rong</creator><creator>Yang, Ju Dong</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5089-1345</orcidid><orcidid>https://orcid.org/0000-0003-3513-1783</orcidid></search><sort><creationdate>20210620</creationdate><title>The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma</title><author>Lee, Yi-Te ; Tran, Benjamin V ; Wang, Jasmine J ; Liang, Icy Y ; You, Sungyong ; Zhu, Yazhen ; Agopian, Vatche G ; Tseng, Hsian-Rong ; Yang, Ju Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-1d54113167994dda2c0d04272aa886c128a266c00b4c4f9964143d6ea69052c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibodies</topic><topic>Biomarkers</topic><topic>Biosynthesis</topic><topic>Cell interactions</topic><topic>Cell signaling</topic><topic>Chromatography</topic><topic>Extracellular vesicles</topic><topic>Hepatitis</topic><topic>Hepatocellular carcinoma</topic><topic>Lipids</topic><topic>Liver cancer</topic><topic>Liver diseases</topic><topic>Malignancy</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Methods</topic><topic>Pathogenesis</topic><topic>Phospholipids</topic><topic>Polyethylene glycol</topic><topic>Polymers</topic><topic>Proteins</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yi-Te</creatorcontrib><creatorcontrib>Tran, Benjamin V</creatorcontrib><creatorcontrib>Wang, Jasmine J</creatorcontrib><creatorcontrib>Liang, Icy Y</creatorcontrib><creatorcontrib>You, Sungyong</creatorcontrib><creatorcontrib>Zhu, Yazhen</creatorcontrib><creatorcontrib>Agopian, Vatche G</creatorcontrib><creatorcontrib>Tseng, Hsian-Rong</creatorcontrib><creatorcontrib>Yang, Ju Dong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Biological Sciences</collection><collection>ProQuest Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yi-Te</au><au>Tran, Benjamin V</au><au>Wang, Jasmine J</au><au>Liang, Icy Y</au><au>You, Sungyong</au><au>Zhu, Yazhen</au><au>Agopian, Vatche G</au><au>Tseng, Hsian-Rong</au><au>Yang, Ju Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2021-06-20</date><risdate>2021</risdate><volume>13</volume><issue>12</issue><spage>3076</spage><pages>3076-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of the leading causes of cancer-related death worldwide. Despite the improvements in surveillance and treatment, the prognosis of HCC remains poor. Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles circulating in the bloodstream and mediating intercellular communication. Emerging studies have shown that EVs play a crucial role in regulating the proliferation, immune escape, and metastasis of HCC. In addition, because EVs are present in the circulation at relatively early stages of disease, they are getting attention as an attractive biomarker for HCC detection. Over the past decade, dedicated efforts have been made to isolate EVs more efficiently and make them useful tools in different clinical settings. In this review article, we provide an overview of the EVs isolation methods and highlight the role of EVs as mediators in the pathogenesis and progression of HCC. Lastly, we summarize the potential applications of EVs in early-stage HCC detection.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34203086</pmid><doi>10.3390/cancers13123076</doi><orcidid>https://orcid.org/0000-0002-5089-1345</orcidid><orcidid>https://orcid.org/0000-0003-3513-1783</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Biomarkers Biosynthesis Cell interactions Cell signaling Chromatography Extracellular vesicles Hepatitis Hepatocellular carcinoma Lipids Liver cancer Liver diseases Malignancy Metastases Metastasis Methods Pathogenesis Phospholipids Polyethylene glycol Polymers Proteins Review |
| title | The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma |
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