Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the ris...
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| Veröffentlicht in: | Genes 2021-06, Vol.12 (6), p.930 |
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| creator | Tu, Min-Yu Han, Kuei-Yang Lan, Ying-Wei Chang, Ku-Yi Lai, Cheng-Wei Staniczek, Theresa Lai, Chung-Yu Chong, Kowit-Yu Chen, Chuan-Mu |
| description | Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women. |
| doi_str_mv | 10.3390/genes12060930 |
| format | Article |
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It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes12060930</identifier><identifier>PMID: 34207210</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Aging ; Body height ; Bone density ; Bone mineral density ; Enzymes ; Fractures ; Gene polymorphism ; Genes ; Health care ; Hormone replacement therapy ; Inflammation ; Interleukin 10 ; Osteoporosis ; Polymorphism ; Post-menopause ; Regression analysis ; Single-nucleotide polymorphism ; Statistical analysis ; Transforming growth factor-b1 ; Variables</subject><ispartof>Genes, 2021-06, Vol.12 (6), p.930</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. 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Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.</description><subject>Aging</subject><subject>Body height</subject><subject>Bone density</subject><subject>Bone mineral density</subject><subject>Enzymes</subject><subject>Fractures</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Health care</subject><subject>Hormone replacement therapy</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Osteoporosis</subject><subject>Polymorphism</subject><subject>Post-menopause</subject><subject>Regression analysis</subject><subject>Single-nucleotide polymorphism</subject><subject>Statistical analysis</subject><subject>Transforming growth factor-b1</subject><subject>Variables</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1LxDAQhoMoKurRe8CLl-rko017ERZxV2HBBfUcsmnqRtpm7bQu-7f8If4msyp-zSUzzMP7zmQIOWZwJkQB54-udcg4ZFAI2CL7HJRIpOTp9q98jxwhPkEMCRwg3SV7QsYuZ7BPcIQYrDe9Dy0NFb2fjJO3V0ZNW9KbacKATqIHnYV63YRuufDYIF35fkFvsXdhGbqAHqlvqaF3_VCuP0SMX5k4mfuBem_pLLq4tsdDslOZGt3R13tAHsZX95fXyfR2cnM5miZWgIJEgTBZbgzP5qooIOdCMSmKqlJSupTbsmRKmZyzWFpheCXnLLUZZHla8Lkz4oBcfOouh3njShu9O1PrZecb0611MF7_7bR-oR_Di45WIucQBU6_BLrwPDjsdePRurqOy4UBNU9lLgEUExE9-Yc-haFr43obSka1FHikkk_Kxm_DzlXfwzDQm4vqPxcV76NQkqw</recordid><startdate>20210618</startdate><enddate>20210618</enddate><creator>Tu, Min-Yu</creator><creator>Han, Kuei-Yang</creator><creator>Lan, Ying-Wei</creator><creator>Chang, Ku-Yi</creator><creator>Lai, Cheng-Wei</creator><creator>Staniczek, Theresa</creator><creator>Lai, Chung-Yu</creator><creator>Chong, Kowit-Yu</creator><creator>Chen, Chuan-Mu</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0974-0673</orcidid><orcidid>https://orcid.org/0000-0003-2461-9150</orcidid><orcidid>https://orcid.org/0000-0002-7524-3010</orcidid><orcidid>https://orcid.org/0000-0002-3137-3833</orcidid></search><sort><creationdate>20210618</creationdate><title>Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients</title><author>Tu, Min-Yu ; 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It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34207210</pmid><doi>10.3390/genes12060930</doi><orcidid>https://orcid.org/0000-0003-0974-0673</orcidid><orcidid>https://orcid.org/0000-0003-2461-9150</orcidid><orcidid>https://orcid.org/0000-0002-7524-3010</orcidid><orcidid>https://orcid.org/0000-0002-3137-3833</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Aging Body height Bone density Bone mineral density Enzymes Fractures Gene polymorphism Genes Health care Hormone replacement therapy Inflammation Interleukin 10 Osteoporosis Polymorphism Post-menopause Regression analysis Single-nucleotide polymorphism Statistical analysis Transforming growth factor-b1 Variables |
| title | Association of TGF-β1 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients |
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