Mapping the expression of transient receptor potential channels across murine placental development
Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast proliferation, invasion, differentiation, and fusion, all of which require calcium signaling. Although certain...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2021-06, Vol.78 (11), p.4993-5014 |
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| creator | De Clercq, Katrien Pérez-García, Vicente Van Bree, Rieta Pollastro, Federica Peeraer, Karen Voets, Thomas Vriens, Joris |
| description | Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast proliferation, invasion, differentiation, and fusion, all of which require calcium signaling. Although certain TRP channels have been shown to contribute to maternal–fetal transport of magnesium and calcium, a role for TRP channels in specific trophoblast functions has been disregarded. Using qRT-PCR and in situ hybridisation, the spatio-temporal expression pattern of TRP channels in the mouse placenta across gestation (E10.5–E18.5) was assessed. Prominent expression was observed for
Trpv2
,
Trpm6
, and
Trpm7
. Calcium microfluorimetry in primary trophoblast cells isolated at E14.5 of gestation further revealed the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells (mTSCs) and mouse embryonic stem cells (mESC) confirmed the specific expression of TRPV2 during placental development. Moreover, TRP channel expression was similar in mTSCs compared to primary trophoblasts and validate mTSC as a model to study TRP channels in placental development. Collectivity, our results identify a specific spatio-temporal TRP channel expression pattern in trophoblasts, suggesting a possible involvement in regulating the process of placentation. |
| doi_str_mv | 10.1007/s00018-021-03837-3 |
| format | Article |
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Trpv2
,
Trpm6
, and
Trpm7
. Calcium microfluorimetry in primary trophoblast cells isolated at E14.5 of gestation further revealed the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells (mTSCs) and mouse embryonic stem cells (mESC) confirmed the specific expression of TRPV2 during placental development. Moreover, TRP channel expression was similar in mTSCs compared to primary trophoblasts and validate mTSC as a model to study TRP channels in placental development. Collectivity, our results identify a specific spatio-temporal TRP channel expression pattern in trophoblasts, suggesting a possible involvement in regulating the process of placentation.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-021-03837-3</identifier><identifier>PMID: 33884443</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Calcium ; Calcium Channels - genetics ; Calcium Channels - metabolism ; Calcium Signaling ; Calcium signalling ; Calcium transport ; Cell Biology ; Cell Differentiation ; Cell Proliferation ; Channels ; Embryo cells ; Female ; Fetuses ; Gene Expression Regulation ; Gestation ; Homeostasis ; Hybridization ; Life Sciences ; Magnesium ; Mice ; Mice, Inbred C57BL ; Mouse Embryonic Stem Cells - cytology ; Mouse Embryonic Stem Cells - metabolism ; Original ; Original Article ; Placenta ; Placenta - metabolism ; Placentation - genetics ; Pregnancy ; Receptors ; Stability ; Stem cell transplantation ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism ; Transient Receptor Potential Channels - genetics ; Transient Receptor Potential Channels - metabolism ; Transient receptor potential proteins ; Trophoblasts ; Trophoblasts - cytology ; Trophoblasts - metabolism ; TRPV Cation Channels - genetics ; TRPV Cation Channels - metabolism</subject><ispartof>Cellular and molecular life sciences : CMLS, 2021-06, Vol.78 (11), p.4993-5014</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6491a6cf9231e1280781b3da1b066f0e22b87377649663ac59e14672c4ded75f3</citedby><cites>FETCH-LOGICAL-c474t-6491a6cf9231e1280781b3da1b066f0e22b87377649663ac59e14672c4ded75f3</cites><orcidid>0000-0002-2502-0409</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233283/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233283/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33884443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Clercq, Katrien</creatorcontrib><creatorcontrib>Pérez-García, Vicente</creatorcontrib><creatorcontrib>Van Bree, Rieta</creatorcontrib><creatorcontrib>Pollastro, Federica</creatorcontrib><creatorcontrib>Peeraer, Karen</creatorcontrib><creatorcontrib>Voets, Thomas</creatorcontrib><creatorcontrib>Vriens, Joris</creatorcontrib><title>Mapping the expression of transient receptor potential channels across murine placental development</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast proliferation, invasion, differentiation, and fusion, all of which require calcium signaling. Although certain TRP channels have been shown to contribute to maternal–fetal transport of magnesium and calcium, a role for TRP channels in specific trophoblast functions has been disregarded. Using qRT-PCR and in situ hybridisation, the spatio-temporal expression pattern of TRP channels in the mouse placenta across gestation (E10.5–E18.5) was assessed. Prominent expression was observed for
Trpv2
,
Trpm6
, and
Trpm7
. Calcium microfluorimetry in primary trophoblast cells isolated at E14.5 of gestation further revealed the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells (mTSCs) and mouse embryonic stem cells (mESC) confirmed the specific expression of TRPV2 during placental development. Moreover, TRP channel expression was similar in mTSCs compared to primary trophoblasts and validate mTSC as a model to study TRP channels in placental development. Collectivity, our results identify a specific spatio-temporal TRP channel expression pattern in trophoblasts, suggesting a possible involvement in regulating the process of placentation.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Calcium Channels - genetics</subject><subject>Calcium Channels - metabolism</subject><subject>Calcium Signaling</subject><subject>Calcium signalling</subject><subject>Calcium transport</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Channels</subject><subject>Embryo cells</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gene Expression Regulation</subject><subject>Gestation</subject><subject>Homeostasis</subject><subject>Hybridization</subject><subject>Life Sciences</subject><subject>Magnesium</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mouse Embryonic Stem Cells - cytology</subject><subject>Mouse Embryonic Stem Cells - metabolism</subject><subject>Original</subject><subject>Original Article</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Placentation - genetics</subject><subject>Pregnancy</subject><subject>Receptors</subject><subject>Stability</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Transient Receptor Potential Channels - genetics</subject><subject>Transient Receptor Potential Channels - metabolism</subject><subject>Transient receptor potential proteins</subject><subject>Trophoblasts</subject><subject>Trophoblasts - cytology</subject><subject>Trophoblasts - metabolism</subject><subject>TRPV Cation Channels - genetics</subject><subject>TRPV Cation Channels - metabolism</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9v1DAQxS1UREvhC_SALHHpJeB_sZ1LJVS1FKmIC0jcLK8z2XWV2MZOqvLt8XaXlnLoyR7Nz2_e-CF0QskHSoj6WAghVDeE0YZwzVXDX6AjKhhpOqLowf4uNft5iF6XclPpVjP5Ch1yrrUQgh8h99Wm5MMazxvAcJcylOJjwHHAc7aheAgzzuAgzTHjFOdaeztit7EhwFiwdTmWgqcl-wA4jdZVogI93MIY01SrN-jlYMcCb_fnMfpxefH9_Kq5_vb5y_mn68YJJeZGio5a6YaOcQqUaaI0XfHe0hWRciDA2EorrlTlpOTWtR1QIRVzoodetQM_Rmc73bSsJui3RrIdTcp-svm3idabp53gN2Ydb41mnDPNq8DpXiDHXwuU2Uy-OBhHGyAuxbCWSi1o25KKvv8PvYlLDnW9SgnRdVRoXSm2o-4_KcPwYIYSs83Q7DI0NUNzn6HZunj37xoPT_6GVgG-A0pthTXkx9nPyP4B8eSpFw</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>De Clercq, Katrien</creator><creator>Pérez-García, Vicente</creator><creator>Van Bree, Rieta</creator><creator>Pollastro, Federica</creator><creator>Peeraer, Karen</creator><creator>Voets, Thomas</creator><creator>Vriens, Joris</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2502-0409</orcidid></search><sort><creationdate>20210601</creationdate><title>Mapping the expression of transient receptor potential channels across murine placental development</title><author>De Clercq, Katrien ; Pérez-García, Vicente ; Van Bree, Rieta ; Pollastro, Federica ; Peeraer, Karen ; Voets, Thomas ; Vriens, Joris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-6491a6cf9231e1280781b3da1b066f0e22b87377649663ac59e14672c4ded75f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Calcium Channels - genetics</topic><topic>Calcium Channels - metabolism</topic><topic>Calcium Signaling</topic><topic>Calcium signalling</topic><topic>Calcium transport</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Channels</topic><topic>Embryo cells</topic><topic>Female</topic><topic>Fetuses</topic><topic>Gene Expression Regulation</topic><topic>Gestation</topic><topic>Homeostasis</topic><topic>Hybridization</topic><topic>Life Sciences</topic><topic>Magnesium</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mouse Embryonic Stem Cells - cytology</topic><topic>Mouse Embryonic Stem Cells - metabolism</topic><topic>Original</topic><topic>Original Article</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Placentation - genetics</topic><topic>Pregnancy</topic><topic>Receptors</topic><topic>Stability</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Clercq, Katrien</au><au>Pérez-García, Vicente</au><au>Van Bree, Rieta</au><au>Pollastro, Federica</au><au>Peeraer, Karen</au><au>Voets, Thomas</au><au>Vriens, Joris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mapping the expression of transient receptor potential channels across murine placental development</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>78</volume><issue>11</issue><spage>4993</spage><epage>5014</epage><pages>4993-5014</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is governed by the processes of trophoblast proliferation, invasion, differentiation, and fusion, all of which require calcium signaling. Although certain TRP channels have been shown to contribute to maternal–fetal transport of magnesium and calcium, a role for TRP channels in specific trophoblast functions has been disregarded. Using qRT-PCR and in situ hybridisation, the spatio-temporal expression pattern of TRP channels in the mouse placenta across gestation (E10.5–E18.5) was assessed. Prominent expression was observed for
Trpv2
,
Trpm6
, and
Trpm7
. Calcium microfluorimetry in primary trophoblast cells isolated at E14.5 of gestation further revealed the functional activity of TRPV2 and TRPM7. Finally, comparing TRP channels expression in mouse trophoblast stem cells (mTSCs) and mouse embryonic stem cells (mESC) confirmed the specific expression of TRPV2 during placental development. Moreover, TRP channel expression was similar in mTSCs compared to primary trophoblasts and validate mTSC as a model to study TRP channels in placental development. Collectivity, our results identify a specific spatio-temporal TRP channel expression pattern in trophoblasts, suggesting a possible involvement in regulating the process of placentation.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33884443</pmid><doi>10.1007/s00018-021-03837-3</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-2502-0409</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular and molecular life sciences : CMLS, 2021-06, Vol.78 (11), p.4993-5014 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Calcium Calcium Channels - genetics Calcium Channels - metabolism Calcium Signaling Calcium signalling Calcium transport Cell Biology Cell Differentiation Cell Proliferation Channels Embryo cells Female Fetuses Gene Expression Regulation Gestation Homeostasis Hybridization Life Sciences Magnesium Mice Mice, Inbred C57BL Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism Original Original Article Placenta Placenta - metabolism Placentation - genetics Pregnancy Receptors Stability Stem cell transplantation Stem cells Stem Cells - cytology Stem Cells - metabolism Transient Receptor Potential Channels - genetics Transient Receptor Potential Channels - metabolism Transient receptor potential proteins Trophoblasts Trophoblasts - cytology Trophoblasts - metabolism TRPV Cation Channels - genetics TRPV Cation Channels - metabolism |
| title | Mapping the expression of transient receptor potential channels across murine placental development |
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