The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS

The characteristics of phthalates had been thought to be similar to endocrine disruptors, which increases cancer risk. The role of phthalates in acquired drug resistance remains unclear. In this study, we investigated the effect of di-(2-ethylhexyl) phthalate (DEHP) on acquired drug resistance in br...

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Veröffentlicht in:	Antioxidants 2021-06, Vol.10 (6), p.949
Hauptverfasser:	Jadhao, Mahendra, Tsai, Eing-Mei, Yang, Ho-Chun, Chen, Yih-Fung, Liang, Shih-Shin, Wang, Tsu-Nai, Teng, Yen-Ni, Huang, Hurng-Wern, Wang, Li-Fang, Chiu, Chien-Chih
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase ABC transporter ABC transporters AKT protein Apoptosis ATP-binding transporter proteins Breast cancer Cancer therapies Caspase-3 Cell growth Cell proliferation Cloning Cytotoxicity Doxorubicin Drug resistance Drug therapy Endocrine disruptors Estrogen receptors Food contamination & poisoning Gene expression Intracellular Irinotecan Kinases Leukemia long DEHP exposure Medical screening Multidrug resistance Pharmacokinetics Phosphatase Proteins ROS tariquidar Topotecan
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