Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review
Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out...
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| Veröffentlicht in: | Nutrients 2021-06, Vol.13 (6), p.1959 |
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| creator | Vanoni, Flora O Milani, Gregorio P Agostoni, Carlo Treglia, Giorgio Faré, Pietro B Camozzi, Pietro Lava, Sebastiano A. G Bianchetti, Mario G Janett, Simone |
| description | Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion. |
| doi_str_mv | 10.3390/nu13061959 |
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G ; Bianchetti, Mario G ; Janett, Simone</creator><creatorcontrib>Vanoni, Flora O ; Milani, Gregorio P ; Agostoni, Carlo ; Treglia, Giorgio ; Faré, Pietro B ; Camozzi, Pietro ; Lava, Sebastiano A. G ; Bianchetti, Mario G ; Janett, Simone</creatorcontrib><description>Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13061959</identifier><identifier>PMID: 34200366</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Alcohol ; Alcohol use ; Alcohols ; Analysis ; Bias ; Blood ; Depletion ; Heterogeneity ; Hypomagnesemia ; Kidneys ; Magnesium ; Meta-analysis ; Metabolism ; Muscles ; Physiological aspects ; Renal function ; Scientific imaging ; Skeletal muscle ; Statistical analysis ; Systematic review</subject><ispartof>Nutrients, 2021-06, Vol.13 (6), p.1959</ispartof><rights>COPYRIGHT 2021 MDPI AG</rights><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-2651fe743b1dcc54b314ef56bb22b5702f6536a45c71e1cc928a6db0efeaebb03</citedby><cites>FETCH-LOGICAL-c450t-2651fe743b1dcc54b314ef56bb22b5702f6536a45c71e1cc928a6db0efeaebb03</cites><orcidid>0000-0001-9808-780X ; 0000-0002-5006-0832 ; 0000-0003-0944-2609 ; 0000-0003-3829-4254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229336/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229336/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Vanoni, Flora O</creatorcontrib><creatorcontrib>Milani, Gregorio P</creatorcontrib><creatorcontrib>Agostoni, Carlo</creatorcontrib><creatorcontrib>Treglia, Giorgio</creatorcontrib><creatorcontrib>Faré, Pietro B</creatorcontrib><creatorcontrib>Camozzi, Pietro</creatorcontrib><creatorcontrib>Lava, Sebastiano A. 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The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.</description><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Alcohols</subject><subject>Analysis</subject><subject>Bias</subject><subject>Blood</subject><subject>Depletion</subject><subject>Heterogeneity</subject><subject>Hypomagnesemia</subject><subject>Kidneys</subject><subject>Magnesium</subject><subject>Meta-analysis</subject><subject>Metabolism</subject><subject>Muscles</subject><subject>Physiological aspects</subject><subject>Renal function</subject><subject>Scientific imaging</subject><subject>Skeletal muscle</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkl1LHDEUhoO0qGy98RcMeCOF0XzPjheFZetHYaXQ1otehSRzZjeSSWwys2X_vbO61ComFzkkz_uEhIPQMcFnjNX4PAyEYUlqUe-hQ4orWkrJ2Yf_6gN0lPM93o4KV5LtowPGKcZMykP0-1YvA2Q3dMUt9NpE73JXuFDMVykGZ4uZt3EVfXmXofjqckwNpIsntpwF7TfZ5UKHpvi5yT10uh8jP2Dt4O8n9LHVPsPRbp2gu6vLX_ObcvH9-tt8tigtF7gvqRSkhYozQxprBTeMcGiFNIZSIypMWymY1FzYigCxtqZTLRuDoQUNxmA2QV-evQ-D6aCxEPqkvXpIrtNpo6J26vVJcCu1jGs1pbRmTI6C050gxT8D5F51LlvwXgeIQ1ZU8CnHlI30BJ28Qe_jkMZveKJ4TWssyAu11B6UC20c77VbqZpVUkylrOXWdfYONc4GOmdjgNaN-68Cn58DNsWcE7T_3kiw2vaCeukF9gidxKQN</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Vanoni, Flora O</creator><creator>Milani, Gregorio P</creator><creator>Agostoni, Carlo</creator><creator>Treglia, Giorgio</creator><creator>Faré, Pietro B</creator><creator>Camozzi, Pietro</creator><creator>Lava, Sebastiano A. 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| subjects | Alcohol Alcohol use Alcohols Analysis Bias Blood Depletion Heterogeneity Hypomagnesemia Kidneys Magnesium Meta-analysis Metabolism Muscles Physiological aspects Renal function Scientific imaging Skeletal muscle Statistical analysis Systematic review |
| title | Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review |
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