Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways

To delineate recurrent oncogenic driver alterations and dysregulated pathways in esophageal adenocarcinoma and to assess their prognostic value. We analyzed a large cohort of patients with lower esophageal and junctional adenocarcinoma, prospectively sequenced by MSK-IMPACT with high-quality clinica...

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Veröffentlicht in:	Clinical cancer research 2021-06, Vol.27 (12), p.3491-3498
Hauptverfasser:	Sihag, Smita, Nussenzweig, Samuel C, Walch, Henry S, Hsu, Meier, Tan, Kay See, Sanchez-Vega, Francisco, Chatila, Walid K, De La Torre, Sergio A, Patel, Assem, Janjigian, Yelena Y, Maron, Steven, Ku, Geoffrey Y, Tang, Laura H, Hechtman, Jaclyn, Shah, Pari M, Wu, Abraham J, Jones, David R, Molena, Daniela, Solit, David B, Schultz, Nikolaus, Berger, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Biomarkers, Tumor - genetics High-Throughput Nucleotide Sequencing Humans Mutation Prognosis
Online-Zugang:	Volltext
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