The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis

The tight regulation of intracellular nucleotides is critical for the self-renewal and lineage specification of hematopoietic stem cells (HSCs). Nucleosides are major metabolite precursors for nucleotide biosynthesis and their availability in HSCs is dependent on their transport through specific mem...

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Veröffentlicht in:	Blood 2021-06, Vol.137 (25), p.3548-3562
Hauptverfasser:	Mikdar, Mahmoud, González-Menéndez, Pedro, Cai, Xiaoli, Zhang, Yujin, Serra, Marion, Dembele, Abdoul K., Boschat, Anne-Claire, Sanquer, Sylvia, Chhuon, Cerina, Guerrera, Ida Chiara, Sitbon, Marc, Hermine, Olivier, Colin, Yves, Le Van Kim, Caroline, Kinet, Sandrina, Mohandas, Narla, Xia, Yang, Peyrard, Thierry, Taylor, Naomi, Azouzi, Slim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - metabolism Animals Equilibrative Nucleoside Transporter 1 - genetics Equilibrative Nucleoside Transporter 1 - metabolism Erythropoiesis Hematopoietic Stem Cells - metabolism Homeostasis Humans Life Sciences Mice Mice, Knockout Red Cells, Iron, and Erythropoiesis
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