Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1)

Plant homeodomain finger protein 1 (PHF1) is an accessory component of the gene silencing complex polycomb repressive complex 2 and recognizes the active chromatin mark, trimethylated lysine 36 of histone H3 (H3K36me3). In addition to its role in transcriptional regulation, PHF1 has been implicated...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-06, Vol.64 (12), p.8510-8522
Hauptverfasser:	Engelberg, Isabelle A, Liu, Jiuyang, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Ottavi, Samantha A, Frye, Stephen V, Kutateladze, Tatiana G, James, Lindsey I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Crystallography, X-Ray DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Ligands Mutagenesis, Site-Directed Nuclear Magnetic Resonance, Biomolecular Peptidomimetics - metabolism Polycomb-Group Proteins - antagonists & inhibitors Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Protein Binding Tudor Domain
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